anti-Rat (Rattus) JAK2 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended JAK2 Antibody (supplied by: Log in to see )

Antigen
Janus Kinase 2 (JAK2) Antibodies
  • JAK2bCA
  • jak2
  • JTK10
  • THCYT3
  • AI504024
  • C81284
  • Fd17
  • JAK-2
  • Janus kinase 2b
  • Janus kinase 2
  • jak2b
  • JAK2
  • Jak2
Epitope
AA 623-666
47
28
19
17
14
13
12
11
10
10
8
7
7
4
4
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
270
156
143
8
6
6
6
2
2
Host
Rabbit
258
23
5
Clonality
Polyclonal
Conjugate
This JAK2 antibody is un-conjugated
11
8
6
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
196
122
111
29
28
26
20
16
9
7
7
3
2
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Catalog No. ABIN729688
$ 318.45
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN265487 IHC (p) WB Rabbit Log in to see Polyclonal 0
1 ABIN319397 IHC (p) Rabbit Tyr570 Log in to see Polyclonal 0
1 ABIN5690023 ELISA IHC (p) WB Rabbit IgG C-Term Log in to see Polyclonal 0
1 ABIN318056 EIA IHC (p) Rabbit pTyr1007 Log in to see Polyclonal 0
1 ABIN729697 IHC (p) WB HRP Rabbit IgG AA 623-666 Log in to see Polyclonal 0
1 ABIN4327879 IHC IHC (p) WB Rabbit pTyr1007 Log in to see Polyclonal 0
1 ABIN740964 IHC (p) WB HRP Rabbit IgG pTyr1007, pTyr1008 Log in to see Polyclonal 0
1 ABIN729690 IHC (p) WB Biotin Rabbit IgG AA 623-666 Log in to see Polyclonal 0
1 ABIN740955 IF (p) IHC (p) WB Rabbit IgG pTyr1007, pTyr1008 Log in to see Polyclonal 1
1 ABIN742853 IF (p) IHC (p) WB Rabbit IgG pTyr221 Log in to see Polyclonal 1
1 ABIN740957 IHC (p) WB Biotin Rabbit IgG pTyr1007, pTyr1008 Log in to see Polyclonal 0
1 ABIN4327881 IHC IHC (p) Rabbit pTyr1007 Log in to see Polyclonal 0
1 ABIN4327885 ELISA ICC IF IHC IHC (p) WB Rabbit C-Term Log in to see Polyclonal 0
1 ABIN4327882 IHC IHC (p) WB Rabbit Log in to see Polyclonal 0

General

Antigen Janus Kinase 2 (JAK2) Antibodies
Epitope AA 623-666
(47), (28), (19), (17), (14), (13), (12), (11), (10), (10), (8), (7), (7), (4), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(270), (156), (143), (8), (6), (6), (6), (2), (2)
Host Rabbit
(258), (23), (5)
Clonality
Polyclonal
Conjugate This JAK2 antibody is un-conjugated
(11), (8), (6), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(196), (122), (111), (29), (28), (26), (20), (16), (9), (7), (7), (3), (2)
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Product Details anti-JAK2 Antibody

Target Details JAK2 Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human JAK2
Isotype IgG

Target Details JAK2

Product Details anti-JAK2 Antibody Application Details Handling Images back to top
Antigen
Alternative Name JAK2 (JAK2 Antibody Abstract)
Background

Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO), or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.

Subcellular location: Cytoplasm, Nucleus, Cell membrane

Synonyms: JTK1, THCYT3, Tyrosine-protein kinase JAK2, Janus kinase 2, JAK-2, JAK2

Gene ID 3717
UniProt O60674
Pathways JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling, Unfolded protein response

Application Details

Product Details anti-JAK2 Antibody Target Details JAK2 Handling Images back to top
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-JAK2 Antibody Target Details JAK2 Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-JAK2 Antibody Target Details JAK2 Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Janus Kinase 2 (JAK2) (AA 623-666) antibody (ABIN729688) Formalin-fixed and paraffin embedded rat kidney tissue with labeled Anti-JAK2 Polyclo...
Flow Cytometry (FACS) image for anti-Janus Kinase 2 (JAK2) (AA 623-666) antibody (ABIN729688) Mouse splenocytes probed with Rabbit Anti-JAK2 Polyclonal Antibody, Unconjugated .