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|Antigen||Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3) Antibodies|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This MAP3K3 antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-MAP3K3 AntibodyTarget Details MAP3K3 Application Details Handling Images
|Specificity||This antibody reacts to MAP Kinase Kinase Kinase 3 (MEKK3) (MAP3K3).|
Species reactivity (expected):Canine, Drosophila, Xenopus, Guinea pig, Hamster, Human, Monkey, Porcine, Rabbit, Rat, Sheep.
Species reactivity (tested):Mouse.
|Immunogen||MAP3K3 antibody was raised against synthetic peptide derived from sequence near the N- terminus of mouse MEKK3.|
Target Details MAP3K3Product Details anti-MAP3K3 Antibody Application Details Handling Images back to top
|Alternative Name||MAP3K3 (MAP3K3 Antibody Abstract)|
|Background||MEKK3, a MAP3K type protein kinase, is a member of several MAP kinase signaling pathways. It regulates both JNK and ERK cascades by phosphorylating and activating MKK4/MAP2K4 and MEK1/MAP2K1, respectively. MEKK3 regulates the ERK5/MAPK7 cascade by phosphorylating MEK5 and the p38 MAP kinase cascade by phosphorylating MEK3/MAP2K3 and MKK6/MAP2K6. MEKK3 (-/-) mouse embryos have demonstrated that the protein is necessary for blood vessel development and suggest that MEKK3 may be a possible target for drugs that control angiogenesis.Synonyms: MAPK/ERK kinase kinase 3, MAPKKK3, MEK kinase 3, MEKK3, Mitogen-activated protein kinase kinase kinase 3|
Application DetailsProduct Details anti-MAP3K3 Antibody Target Details MAP3K3 Handling Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-MAP3K3 Antibody Target Details MAP3K3 Application Details Images back to top
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
ImagesProduct Details anti-MAP3K3 Antibody Target Details MAP3K3 Application Details Handling back to top