anti-Mouse (Murine) Insulin Receptor antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended Insulin Receptor Antibody (supplied by: Log in to see )

Antigen
Insulin Receptor (INSR) Antibodies
  • 18402
  • CG18402
  • DIHR
  • DILR
  • DIR
  • DIRH
  • DIRbeta
  • DInR
  • DInr
  • Dir-a
  • Dir-b
  • Dmel\\CG18402
  • INR
  • INS
  • IR
  • Inr
  • Inr-alpha
  • Inr-beta
  • InsR
  • dINR
  • dIR
  • dIRH
  • dInR
  • dInr
  • dInsR
  • dinr
  • dir
  • er10
  • inr
  • insulin/insulin-like growth factor receptor
  • l(3)05545
  • l(3)93Dj
  • l(3)er10
  • lnR
  • INSR
  • NV14476
  • CD220
  • HHF5
  • 4932439J01Rik
  • D630014A15Rik
  • IR-A
  • IR-B
  • ir-A
  • ir
  • cd220
  • hhf5
  • CTK-1
  • Insulin-like receptor
  • insulin receptor
  • insulin receptor precursor
  • InR
  • INSR
  • Insr
  • insr
  • DAF-2
Reactivity
Human, Mouse (Murine), Rat (Rattus)
329
131
94
23
22
21
20
17
17
9
5
5
3
1
1
1
1
1
Host
Rabbit
253
96
13
1
1
Clonality
Polyclonal
Conjugate
This Insulin Receptor antibody is un-conjugated
27
18
13
11
10
9
6
5
4
4
4
4
3
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
217
143
74
57
47
45
17
13
12
12
11
8
7
7
6
3
2
2
Options
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Catalog No. ABIN671841
$ 307.45
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2814856 IF (p) Alexa Fluor 594 Rabbit IgG AA 50-100 Log in to see Polyclonal
1 ABIN671846 IF (p) Cy5.5 Rabbit IgG Log in to see Polyclonal
1 ABIN671848 IF (p) FITC Rabbit IgG Log in to see Polyclonal
1 ABIN671844 IF (p) Cy3 Rabbit IgG Log in to see Polyclonal
1 ABIN671845 IF (p) Cy5 Rabbit IgG Log in to see Polyclonal
1 ABIN671847 IF (p) Cy7 Rabbit IgG Log in to see Polyclonal
1 ABIN902852 IF (p) Alexa Fluor 647 Rabbit IgG Log in to see Polyclonal
1 ABIN902851 IF (p) Alexa Fluor 555 Rabbit IgG Log in to see Polyclonal
1 ABIN902849 IF (p) Alexa Fluor 350 Rabbit IgG Log in to see Polyclonal
1 ABIN902850 IF (p) Alexa Fluor 488 Rabbit IgG Log in to see Polyclonal
1 ABIN5005447 IF (p) Alexa Fluor 750 Rabbit IgG AA 50-100 Log in to see Polyclonal
1 ABIN5005446 IF (p) Alexa Fluor 680 Rabbit IgG AA 50-100 Log in to see Polyclonal

General

Antigen Insulin Receptor (INSR) Antibodies
Reactivity Human, Mouse (Murine), Rat (Rattus)
(329), (131), (94), (23), (22), (21), (20), (17), (17), (9), (5), (5), (3), (1), (1), (1), (1), (1)
Host Rabbit
(253), (96), (13), (1), (1)
Clonality
Polyclonal
Conjugate This Insulin Receptor antibody is un-conjugated
(27), (18), (13), (11), (10), (9), (6), (5), (4), (4), (4), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(217), (143), (74), (57), (47), (45), (17), (13), (12), (12), (11), (8), (7), (7), (6), (3), (2), (2)
Pubmed 2 references available
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Product Details anti-Insulin Receptor Antibody

Target Details Insulin Receptor Application Details Handling References for anti-Insulin Receptor antibody (ABIN671841) Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human Insulin Receptor
Isotype IgG

Target Details Insulin Receptor

Product Details anti-Insulin Receptor Antibody Application Details Handling References for anti-Insulin Receptor antibody (ABIN671841) Images back to top
Antigen
Alternative Name Insulin Receptor (INSR Antibody Abstract)
Background

Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD, regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway.

Subcellular location: Extracellular

Synonyms: HHF5, CD220, Insulin receptor, IR, INSR

Gene ID 3643
UniProt P06213
Research Area Cardiovascular, Atherosclerosis, Tyrosine Kinases, Hormones, Diabetes, Receptors
Pathways NF-kappaB Signaling, RTK Signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity

Application Details

Product Details anti-Insulin Receptor Antibody Target Details Insulin Receptor Handling References for anti-Insulin Receptor antibody (ABIN671841) Images back to top
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-Insulin Receptor Antibody Target Details Insulin Receptor Application Details References for anti-Insulin Receptor antibody (ABIN671841) Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

References for anti-Insulin Receptor antibody (ABIN671841)

Product Details anti-Insulin Receptor Antibody Target Details Insulin Receptor Application Details Handling Images back to top
Product cited in:

Tian, Bai, Chen, Fang, Liu, Chen: "Anti-diabetic effect of methylswertianin and bellidifolin from Swertia punicea Hemsl. and its potential mechanism." in: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 17, Issue 7, pp. 533-9, 2010

Bai, Chen, Liu, Tian, Zhou, Liu, Fang, Chen: "Effects of water extract and crude polysaccharides from Liriope spicata var. prolifera on InsR/IRS-1/PI3K pathway and glucose metabolism in mice." in: Journal of ethnopharmacology, Vol. 125, Issue 3, pp. 482-6, 2009

Images

Product Details anti-Insulin Receptor Antibody Target Details Insulin Receptor Application Details Handling References for anti-Insulin Receptor antibody (ABIN671841) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Insulin Receptor (INSR) antibody (ABIN671841) Formalin-fixed and paraffin embedded rat liver tissue labeled Anti-Insulin Receptor/C...