We are preparing the requested document. Please wait, this may take a while...!
|Antigen||Nerve Growth Factor Receptor (NGFR) Antibodies|
|Reactivity||Rat (Rattus) Alternatives|
|Conjugate||This NGFR antibody is un-conjugated Alternatives|
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
|4 references available|
|Supplier||Log in to see|
Product Details anti-NGFR AntibodyTarget Details NGFR Application Details Handling References for anti-NGFR antibody (ABIN350707) Images
|Specificity||Specific for rat p75NTR.|
|Immunogen||Nerve growth factor receptor (TNFR superfamily, member 16)|
|Plasmids, Primers & others|
Target Details NGFRProduct Details anti-NGFR Antibody Application Details Handling References for anti-NGFR antibody (ABIN350707) Images back to top
|Alternative Name||p75NTR (NGFR Antibody Abstract)|
Function: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
Subunit: Homodimer, disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1.
Subcellular location: Membrane, Single-pass type I membrane protein. Also known as: TNR16, low-affinity nerve growth factor receptor, NGF receptor, Gp80-LNGFR, p75 ICD, low affinity neurotrophin receptor p75NTR, Tnfrsf16, Ngfr, p75, LNGFR, RNNGFRR.
|Pathways||NF-kappaB Signaling, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding|
Application DetailsProduct Details anti-NGFR Antibody Target Details NGFR Handling References for anti-NGFR antibody (ABIN350707) Images back to top
A working concentration of 5-15 µg/ml is recommended. This antibody is suitable for use in paraformaldehyde fixed, alcohol fixed and paraffin-embedded sections.
The optimal working solution should be determined by the end user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-NGFR Antibody Target Details NGFR Application Details References for anti-NGFR antibody (ABIN350707) Images back to top
|Reconstitution||Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.|
|Handling Advice||Avoid freeze and thaw cycles.|
|Storage||4 °C/-20 °C|
|Storage Comment||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Expiry Date||12 months|
References for anti-NGFR antibody (ABIN350707)Product Details anti-NGFR Antibody Target Details NGFR Application Details Handling Images back to top
Sivilia, Paradisi, DIntino, Fernandez, Pirondi, Lorenzini, Calzua: "Skin homeostasis during inflammation: a role for nerve growth factor." in: Histology and histopathology, Vol. 23, Issue 1, pp. 1-10, 2007
Sposato, Manni, Chaldakov, Aloe: "Streptozotocin-induced diabetes is associated with changes in NGF levels in pancreas and brain." in: Archives italiennes de biologie, Vol. 145, Issue 2, pp. 87-97, 2007
Nemoto, Kageyama, Hagiwara, Tashiro, Tomita, Tomita, Hano, Nishio, Ueyama: "Mutation of low affinity nerve growth factor receptor gene in spontaneously hypertensive and stroke-prone spontaneously hypertensive rats: one of the promising candidate genes for hypertension." in: Brain research, Vol. 655, Issue 1-2, pp. 267-70, 1995
Johnson, Lanahan, Buck, Sehgal, Morgan, Mercer, Bothwell, Chao: "Expression and structure of the human NGF receptor." in: Cell, Vol. 47, Issue 4, pp. 545-54, 1986
ImagesProduct Details anti-NGFR Antibody Target Details NGFR Application Details Handling References for anti-NGFR antibody (ABIN350707) back to top