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|Antigen||Sequestosome 1 (SQSTM1) Antibodies|
|Epitope||AA 80-130 Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This SQSTM1 antibody is un-conjugated Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|4 references available|
|Supplier||Log in to see|
Product Details anti-SQSTM1 AntibodyTarget Details SQSTM1 Application Details Handling References for anti-SQSTM1 antibody (ABIN682153) Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human SQSTM1/Ubiquitin-binding protein p62|
Target Details SQSTM1Product Details anti-SQSTM1 Antibody Application Details Handling References for anti-SQSTM1 antibody (ABIN682153) Images back to top
|Alternative Name||Sqstm1 (SQSTM1 Antibody Abstract)|
Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.
Subcellular location: Cytoplasm, Nucleus
Synonyms: p60, p62, A170, OSIL, PDB3, ZIP3, p62B, Sequestosome-1, EBI3-associated protein of 60 kDa, EBIAP, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, Ubiquitin-binding protein p62, SQSTM1, ORCA
|Pathways||NF-kappaB Signaling, Neurotrophin Signaling Pathway, Autophagy|
Application DetailsProduct Details anti-SQSTM1 Antibody Target Details SQSTM1 Handling References for anti-SQSTM1 antibody (ABIN682153) Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-SQSTM1 Antibody Target Details SQSTM1 Application Details References for anti-SQSTM1 antibody (ABIN682153) Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|
References for anti-SQSTM1 antibody (ABIN682153)Product Details anti-SQSTM1 Antibody Target Details SQSTM1 Application Details Handling Images back to top
|Product cited in:||
Kuo, Weng, Chang, Huang, Lin, Chuang, Lin, Liou, Tai, Lin, Wang: "Altered mitochondrial dynamics and response to insulin in cybrid cells harboring a diabetes-susceptible mitochondrial DNA haplogroup." in: Free radical biology & medicine, Vol. 96, pp. 116-29, 2016 Method employed by authors: Western Blotting (WB) (Sample species: Human).
Xia, Gao, Zhang, Wang, Zhao, Che, Ao, Yang, Wang, Lei: "Autophagy mediated by arginine depletion activation of the nutrient sensor GCN2 contributes to interferon-γ-induced malignant transformation of primary bovine mammary epithelial cells." in: Cell death discovery, Vol. 2, pp. 15065, 2016 Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Cow (Bovine)). Further details: Sample: mammary gland
Cui, Luo, Li, Li, Wang: "Changes of intracellular Ca2+ in quercetin-induced autophagy progression." in: Acta biochimica et biophysica Sinica, Vol. 47, Issue 11, pp. 908-14, 2015 Method employed by authors: Western Blotting (WB) (Sample species: Human).
Chen, Wei, Nie, Lin, Tian, Liu, Yu, Cheng, Yan, Wang, Liu, Deng, Lai, Zhou, Zhang, Lin, Chen: "?-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in asenescence-accelerated prone 8 mice." in: Brain research, Vol. 1552, pp. 41-54, 2014 Method employed by authors: Western Blotting (WB) (Sample species: Mouse (Murine)). Further details: Sample: brain
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