anti-Human TNFRSF10B antibody for Flow Cytometry

Recommended TNFRSF10B Antibody (supplied by: Log in to see )

Antigen
Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) Antibodies
  • TNFRSF10B
  • dr5
  • cd262
  • killer
  • trick2
  • trickb
  • xDR-M1
  • xDR-M2
  • ztnfr9
  • trailr2
  • trick2a
  • trick2b
  • CD262
  • DR5
  • KILLER
  • KILLER/DR5
  • TRAIL-R2
  • TRAILR2
  • TRICK2
  • TRICK2A
  • TRICK2B
  • TRICKB
  • ZTNFR9
  • Ly98
  • MK
  • tumor necrosis factor receptor superfamily, member 10b
  • tumor necrosis factor receptor superfamily member 10b S homeolog
  • tumor necrosis factor receptor superfamily member 10b L homeolog
  • tumor necrosis factor receptor superfamily member 10b
  • TNF receptor superfamily member 10b
  • Tnfrsf10b
  • TNFRSF10B
  • tnfrsf10b.S
  • tnfrsf10b.L
  • tnfrsf10b
Epitope
Extracellular Domain
45
14
13
12
10
10
9
8
8
8
7
5
5
5
5
5
4
4
4
3
3
3
3
3
3
2
2
2
1
1
1
1
1
1
Reactivity
Human
301
69
29
2
1
1
1
1
Host
Mouse
182
147
8
6
2
Clonality
Monoclonal
Conjugate
This TNFRSF10B antibody is conjugated to PE
19
17
16
6
5
4
4
4
4
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
198
130
68
61
39
35
30
27
14
13
13
8
3
3
3
2
1
1
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Catalog No. ABIN192359
$ 680.82
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
22.86386 ABIN4898056 FACS PE Mouse IgG2b AA 56-182 Log in to see 71908 13
21.572235 ABIN1169245 FACS Func ICC IHC IP Mouse IgG1 Log in to see HS201 6
18.572235 ABIN1169244 FACS IHC Mouse IgG1 Log in to see TR2-21 0
17.072235 ABIN1383913 FACS PE Mouse IgG1 Log in to see B-K29 1
17.072235 ABIN1383914 FACS Mouse IgG1 Log in to see B-K29 2
15.572235 ABIN376980 FACS Rabbit IgG Log in to see Polyclonal 0
14.5 ABIN4900599 CyTOF FACS Mouse IgG2b AA 56-182 Log in to see 71908 17
12.572235 ABIN1169241 ICC FACS Atto 647N Mouse IgG1 Log in to see HS201 0
12.572235 ABIN1169240 ICC FACS Atto 488 Mouse IgG1 Log in to see HS201 0
12.572235 ABIN1169242 FACS Func ICC IHC IP Biotin Mouse IgG1 Log in to see HS201 0
12.572235 ABIN1169239 ICC FACS FITC Mouse IgG1 Log in to see HS201 0
12.572235 ABIN1169243 Func ICC FACS IP Mouse IgG1 Log in to see HS201 0
12.572235 ABIN192358 FACS FITC Mouse IgG1 Extracellular Domain Log in to see DR5-01-1 1
12.572235 ABIN94304 FACS Mouse IgG1 Extracellular Domain Log in to see DR5-01-1 1
12.572235 ABIN6240812 FACS APC Mouse IgG1 Extracellular Domain Log in to see DR5-01-1 0
12.572235 ABIN2139414 FACS Biotin Mouse IgG1 kappa Log in to see DJR2-4 0
9.363859 ABIN1996884 FACS PE Rabbit IgG AA 1-182 Log in to see 102 0
9.363859 ABIN4898057 FACS Alexa Fluor 647 Mouse IgG2b AA 56-182 Log in to see 71908 0
9.363859 ABIN2663241 FACS PE Mouse IgG1 kappa Log in to see DJR2-4 (7-8) 9
9.363859 ABIN1996881 FACS ELISA Rabbit IgG AA 1-182, Extracellular Domain Log in to see 102 0

General

Antigen Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) Antibodies
Epitope Extracellular Domain
(45), (14), (13), (12), (10), (10), (9), (8), (8), (8), (7), (5), (5), (5), (5), (5), (4), (4), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity Human
(301), (69), (29), (2), (1), (1), (1), (1)
Host Mouse
(182), (147), (8), (6), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This TNFRSF10B antibody is conjugated to PE
(19), (17), (16), (6), (5), (4), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Flow Cytometry (FACS)
(198), (130), (68), (61), (39), (35), (30), (27), (14), (13), (13), (8), (3), (3), (3), (2), (1), (1)
Pubmed 2 references available
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Product Details anti-TNFRSF10B Antibody

Target Details TNFRSF10B Application Details Handling References for anti-TNFRSF10B antibody (ABIN192359) Images
Specificity The antibody DR5-01-1 recognizes an extracellular domain of TRAIL-R2 (DR5). TRAIL-R2 is one of two TNF superfamily member intracellular death domain containing receptors for TRAIL (APO2L).
Characteristics The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Immunogen Recombinant fusion protein of human IgG heavy chain and extracellular domain of DR5.
Clone DR5-01-1
Isotype IgG1
Plasmids, Primers & others

Target Details TNFRSF10B

Product Details anti-TNFRSF10B Antibody Application Details Handling References for anti-TNFRSF10B antibody (ABIN192359) Images back to top
Antigen
Alternative Name TNFRSF10B (TNFRSF10B Antibody Abstract)
Background TRAIL-R2 (CD262, DR5) is one of two TNF superfamily member intracellular death domain containing receptors for TRAIL (APO2L). Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including tumor necrosis factor (TNF) and Fas ligand in the TNF family through their death domain containing receptors, TNF receptor 1 (TNFR1) and Fas, respectively. Another member in the TNF family has been identified and designated TRAIL (for TNF related apoptosis inducing ligand) and Apo2L (for Apo2 ligand). Receptors for TRAIL include two death domain containing receptors, DR4 and DR5, as well as two decoy receptors, DcR1 and DcR2, lacking the intracellular signaling death domain. DcR1 (also called TRID), like the related death receptors DR4 and DR5, contains two extracellular cysteine rich domains. However, DcR1 contains no intracellular death domain and is thus incapable of signaling apoptosis. It has been suggested DcR1 is responsible for TRAIL resistance in normal human tissues including heart, placenta, lung, liver, kidney, spleen, and bone marrow. DR5 is a member of the TNF receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor related apoptosis inducing ligand (TNFSF10/TRAIL/APO2L), and transduces apoptosis signal. Studies with FADD deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
Pathways p53 Signaling, Apoptosis, Positive Regulation of Endopeptidase Activity

Application Details

Product Details anti-TNFRSF10B Antibody Target Details TNFRSF10B Handling References for anti-TNFRSF10B antibody (ABIN192359) Images back to top
Application Notes The reagent is designed for Flow Cytometry analysis.Suggested working dilution is 5 μg/mL. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-TNFRSF10B Antibody Target Details TNFRSF10B Application Details References for anti-TNFRSF10B antibody (ABIN192359) Images back to top
Concentration 0.1 mg/mL
Buffer The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2 % (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze.
Avoid prolonged exposure to light.
Storage 4 °C
Storage Comment Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.

References for anti-TNFRSF10B antibody (ABIN192359)

Product Details anti-TNFRSF10B Antibody Target Details TNFRSF10B Application Details Handling Images back to top
Product cited in:

Vondálová Blanárová, Jelínková, Szöor, Skender, Soucek, Horváth, Vaculová, Andera, Sova, Szöllosi, Hofmanová, Vereb, Kozubík: "Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway." in: Carcinogenesis, Vol. 32, Issue 1, pp. 42-51, 2010

Background publications

Corallini, Milani, Nicolin, Secchiero: "TRAIL, caspases and maturation of normal and leukemic myeloid precursors." in: Leukemia & lymphoma, Vol. 47, Issue 8, pp. 1459-68, 2006

Images

Product Details anti-TNFRSF10B Antibody Target Details TNFRSF10B Application Details Handling References for anti-TNFRSF10B antibody (ABIN192359) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (Extracellular Domain) antibody (PE) (ABIN192359) Surface staining of CD262 on CD262-transfectants with the antibody to CD262 (DR5-01-1...