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Submit your validation data for this product and get a full refund. I want to validate this productRelevance Score | ABIN | Application | Conjugate | Host | Isotype | Epitope | Supplier | Clonality | References | Details |
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12.811332 | ABIN4901397 | ELISA WB | Mouse | IgG1 | Log in to see | 7F4-F8-G11 | 0 | |||
12.811332 | ABIN2139416 | WB | Rabbit | IgG | Log in to see | Polyclonal | 0 | |||
12.251972 | ABIN1030367 | ICC ELISA WB | Rabbit | C-Term | Log in to see | Polyclonal | 2 | |||
9.251972 | ABIN222914 | WB | Rabbit | IgG | Log in to see | Polyclonal | 1 | |||
8.5 | ABIN4900408 | CyTOF FACS Neut WB | Goat | IgG | AA 53-177 | Log in to see | Polyclonal | 3 | ||
7.751972 | ABIN1860800 | ICC IHC WB | Rabbit | IgG | AA 54-180 | Log in to see | Polyclonal | 0 | ||
7.751972 | ABIN1173677 | ICC IHC WB | Rabbit | IgG | AA 233-367 | Log in to see | Polyclonal | 0 | ||
7.751972 | ABIN2904401 | IF/ICC IHC IP WB | Rabbit | AA 54-180 | Log in to see | Polyclonal | 0 | |||
7.751972 | ABIN2904400 | IF/ICC IHC IP WB | Rabbit | AA 233-367 | Log in to see | Polyclonal | 0 | |||
7.751972 | ABIN2431263 | ELISA WB | Rabbit | IgG | Log in to see | Polyclonal | 0 | |||
7 | ABIN213934 | ICC IF IHC IHC (p) WB | Rabbit | IgG | C-Term | Log in to see | Polyclonal | 0 | ||
5.5 | ABIN4898975 | FACS WB | Biotin | Goat | IgG | AA 1-177 | Log in to see | Polyclonal | 1 | |
4.751972 | ABIN4903511 | ICC WB | Mouse | IgG | Log in to see | 0 | ||||
4.751972 | ABIN3069405 | IF/ICC WB | Mouse | IgG | Log in to see | 0 | ||||
4.751972 | ABIN187721 | WB | Rabbit | AA 388-407 | Log in to see | Polyclonal | 0 | |||
4 | ABIN791067 | IHC ELISA WB | Rabbit | IgG | Internal Region | Log in to see | Polyclonal | 0 | ||
4 | ABIN733118 | IF (p) IHC (p) WB | Rabbit | IgG | Log in to see | Polyclonal | 0 | |||
4 | ABIN241639 | WB | Rabbit | Log in to see | Polyclonal | 0 | ||||
4 | ABIN1733772 | ICC IHC (p) WB | Rabbit | IgG | Log in to see | Polyclonal | 0 | |||
1 | ABIN1002207 | ICC ELISA WB | Rabbit | IgG | Log in to see | Polyclonal | 4 |
General |
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Antigen | Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) Antibodies |
Epitope | AA 233-440 Alternatives |
Reactivity | Human, Mouse (Murine), Rat (Rattus) Alternatives |
Host | Rabbit Alternatives |
Clonality | |
Conjugate | This TNFRSF10B antibody is un-conjugated Alternatives |
Application |
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Alternatives
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1 reference available |
Supplier | Log in to see |
Product Details anti-TNFRSF10B AntibodyTarget Details TNFRSF10B Application Details Handling References for anti-TNFRSF10B antibody (ABIN5518794) Images |
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Purpose | Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 10B(TNFRSF10B) detection. Tested with WB, IHC-P in Human,Mouse,Rat. |
Cross-Reactivity (Details) | No cross reactivity with other proteins. |
Characteristics |
Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 10B(TNFRSF10B) detection. Tested with WB, IHC-P in Human,Mouse,Rat. Gene Name: tumor necrosis factor receptor superfamily, member 10b Protein Name: Tumor necrosis factor receptor superfamily member 10B |
Purification | Immunogen affinity purified. |
Immunogen | E.coli-derived human DR5 recombinant protein (Position: K233-S440). Human DR5 shares 48.4% amino acid (aa) sequence identity with mouse DR5. |
Isotype | IgG |
Plasmids, Primers & others | |
Target Details TNFRSF10BProduct Details anti-TNFRSF10B Antibody Application Details Handling References for anti-TNFRSF10B antibody (ABIN5518794) Images back to top |
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Antigen | |
Alternative Name | TNFRSF10B (TNFRSF10B Antibody Abstract) |
Background |
TNFRSF10B(Tumor necrosis factor receptor superfamily, member 10b) is a human gene. It is also known as DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5. The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. Mice have a homologous gene, tnfrsf10b that has been essential in the elucidation of the function of this gene in humans. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.By analysis of radiation hybrid panels, this gene is mapped to chromosome 8p22-p21. Northern blot analysis indicated that TRAILR2 was expressed as a 4.4-kb mRNA in all tissues tested, with the highest levels of expression in peripheral blood lymphocytes, spleen, and ovary. Synonyms: CD262 antigen | Cytotoxic TRAIL receptor 2 | DR5 | Dr5 | Killer | KILLER | O14763 | TNFRSF10B | TR10B | trail r2 | trailr 2 | TRAILR2 | TRAIL-R2 | TRICK2 | TRICK2A | TRICK2B |
Gene ID | 8795 |
UniProt | O14763 |
Pathways | p53 Signaling, Apoptosis, Positive Regulation of Endopeptidase Activity |
Application DetailsProduct Details anti-TNFRSF10B Antibody Target Details TNFRSF10B Handling References for anti-TNFRSF10B antibody (ABIN5518794) Images back to top |
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Application Notes |
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections. Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users. |
Comment |
Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P). |
Restrictions | For Research Use only |
HandlingProduct Details anti-TNFRSF10B Antibody Target Details TNFRSF10B Application Details References for anti-TNFRSF10B antibody (ABIN5518794) Images back to top |
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Format | Lyophilized |
Reconstitution | Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL. |
Concentration | 500 μg/mL |
Buffer | Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide. |
Preservative | Sodium azide |
Precaution of Use | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Storage | 4 °C,-20 °C |
Storage Comment |
At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing. |
References for anti-TNFRSF10B antibody (ABIN5518794)Product Details anti-TNFRSF10B Antibody Target Details TNFRSF10B Application Details Handling Images back to top |
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Product cited in: |
Liu, Zuo, Wang, Chen, Yang, Wang, Zhu: "miR-942 decreases TRAIL-induced apoptosis through ISG12a downregulation and is regulated by AKT." in: Oncotarget, Vol. 5, Issue 13, pp. 4959-71, 2014 |
ImagesProduct Details anti-TNFRSF10B Antibody Target Details TNFRSF10B Application Details Handling References for anti-TNFRSF10B antibody (ABIN5518794) back to top |
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Supplier Images |
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