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Human Polyclonal RNF7 Primary Antibody for ELISA, IHC - ABIN4350824
Begley, Kasina, Mehra, Adsule, Admon, Lonigro, Chinnaiyan, Macoska: CXCL5 promotes prostate cancer progression. in Neoplasia (New York, N.Y.) 2008
Show all 3 Pubmed References
Human Polyclonal RNF7 Primary Antibody for ELISA, WB - ABIN4350823
Huang, Ayrault, Hunt, Taherbhoy, Duda, Scott, Borg, Neale, Murray, Roussel, Schulman: E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. in Molecular cell 2009
RNF7 gene variant is associated with the risk of developing liver fibrosis and cirrhosis in an Eastern European population.
MAF1 (show MAF1 Antibodies), RNF7 and SETD3 (show SETD3 Antibodies) are identified as PCNA (show PCNA Antibodies)-associated proteins in human cells and given this interaction with PCNA (show PCNA Antibodies), Maf1 (show MAF1 Antibodies), RNF7, and SetD3 (show SETD3 Antibodies) are potentially involved in DNA replication, DNA repair, or associated processes.
These findings indicate that Rbx1 and Rbx2 can both activate Cul5 (show CUL5 Antibodies)-Vif (show BTG1 Antibodies) E3 ligase in vitro, but they may undergo a more delicate selection mechanism in vivo.
SAG (show DMBT1 Antibodies) plays an important role in regulating ionizing radiation-induced apoptosis
The findings showed that SAG (show DMBT1 Antibodies) E3 ubiquitin ligase (show MUL1 Antibodies) plays an essential role in cancer cell proliferation and tumor growth
SAG (show DMBT1 Antibodies) possesses a potent peroxidase property to decompose hydrogen peroxide in the presence of dithiothreitol
sensitive to apoptosis gene protein inhibits peroxynitrite-induced DNA damage.
results indicate that protein kinase (show CDK7 Antibodies) CKII (show CSNK2A1 Antibodies) may control IkappaBalpha (show NFKBIA Antibodies) and p27Kip1 (show CDKN1B Antibodies) degradation and thereby G1/S phase transition through the phosphorylation of threonine 10 within CKBBP1 protein
These studies suggested that CK2 (show CSNK2A1 Antibodies) might regulate SAG (show DMBT1 Antibodies)-SCF (show KITLG Antibodies) E3 ligase activity through modulating SAG's stability, rather than its enzymatic activity directly.
Endogenous levels of pro-caspase 3 (show CASP3 Antibodies) were decreased by overexpression of SAG (show DMBT1 Antibodies) protein.
RBX2, a core component of the E3 ubiquitin ligase (show MUL1 Antibodies) CRL5, is essential for retinal layering and function. RBX2 regulates the final cell position of rod bipolar cells, cone photoreceptors and Muller glia. Our data indicate that sustained RELN (show RELN Antibodies)/DAB1 (show DAB1 Antibodies) signaling, triggered by depletion of RBX2 or SOCS7 (show SOCS7 Antibodies) - a CRL5 substrate adaptor known to recruit DAB1 (show DAB1 Antibodies) - causes rod bipolar cell misposition.
SAG is a novel molecular target that regulates T-cell responses and that inhibiting neddylation with the clinically available small-molecule MLN4924 may represent a novel strategy to mitigate T-cell-mediated immunopathologies, such as graft-versus-host disease.
Attenuation of SAG expression, exacerbates 4-hydroxy-2-nonenal-induced apoptosis and hypertrophy via a disruption of the cellular redox balance.
Inactivation of Sag/Rbx2/Roc2 e3 ubiquitin ligase triggers senescence and inhibits kras-induced immortalization.
as a novel substrate of SAG-betaTrCP (show BTRC Antibodies) E3 ligase. By degrading Erbin (show ERBB2IP Antibodies) and Nrf2 (show NFE2L2 Antibodies), Sag activates the Ras-Raf (show RAF1 Antibodies) pathway and causes ROS (show ROS1 Antibodies) accumulation to trigger autophagy and senescence
Sag is a Kras-cooperating oncogene (show RAB1A Antibodies) that promotes lung tumorigenesis
identifies NF1 as a physiological substrate of SAG-CUL1-FBXW7 E3 ligase and establishes a ubiquitin-dependent regulatory mechanism for the NF1-RAS pathway during embryogenesis
Thus, we concluded that SAG is a cellular protective molecule, which appears to function as an antioxidant, suppressing MPP (show MPZ Antibodies)(+)-induced neurotoxicity.
SAG accelerates ultraviolet B-induced skin hyperplasia, but not carcinogenesis.
The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.
CKII beta-binding protein 1
, RING-box protein 2
, regulator of cullins 2
, sensitive to apoptosis gene protein
, sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2
, zinc RING finger protein SAG