VTCN1 Protein (His tag)
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- Target See all VTCN1 Proteins
- VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1))
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This VTCN1 protein is labelled with His tag.
- Application
- Western Blotting (WB)
- Characteristics
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Measured by its ability to inhibit anti-CD3 antibody induced IL-2 secretion in human T lymphocytes. The ED50 for this effect is typically 0. 75 - 3 μg/mL.
- Purity
- >90 % as determined by SDS-PAGE.
- Top Product
- Discover our top product VTCN1 Protein
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V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) (AA 29-258) protein (His-Avi Tag)
VTCN1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) (AA 33-194) protein (Fc Tag)VTCN1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) (AA 29-258) protein (Fc Tag)VTCN1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) protein (His-Avi Tag,Biotin)VTCN1 Origin: Human Host: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) (AA 33-194) protein (His tag)VTCN1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) (AA 29-258) protein (His tag)VTCN1 Origin: Rhesus Monkey, Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) (AA 33-194) protein (Fc Tag)VTCN1 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) (AA 33-191) protein (His tag)VTCN1 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) (Active) protein (Biotin)VTCN1 Origin: Human Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE. Active
V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) (Active) protein (His tag)VTCN1 Origin: Rhesus Monkey Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE. Active
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- Application Notes
- This recombinant protein can be used for WB. For research use only.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Storage
- -80 °C,-20 °C
- Storage Comment
- Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
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- Target
- VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1))
- Alternative Name
- VTCN1 (VTCN1 Products)
- Synonyms
- B7h4 Protein, B7s1 Protein, B7x Protein, BC032925 Protein, B7-H4 Protein, B7H4 Protein, B7S1 Protein, B7X Protein, B7h.5 Protein, PRO1291 Protein, VCTN1 Protein, RGD1311204 Protein, V set domain containing T cell activation inhibitor 1 L homeolog Protein, V-set domain containing T cell activation inhibitor 1 Protein, V-set domain containing T-cell activation inhibitor 1 Protein, V set domain containing T cell activation inhibitor 1 Protein, vtcn1.L Protein, VTCN1 Protein, vtcn1 Protein, Vtcn1 Protein
- Background
- V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.
- Molecular Weight
- 26.1 kDa
- Gene ID
- 79679
- NCBI Accession
- NP_078902
- UniProt
- Q7Z7D3
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