Glycoprotein / GP (Virus) (AA 67-297) protein (His tag)
-
- Target
- Glycoprotein / GP (Virus)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 67-297
-
Origin
- Human Respiratory Syncytial Virus (hRSV)
-
Source
- HEK-293 Cells
- Purification tag / Conjugate
- His tag
- Sequence
- AA 67-297
- Characteristics
- rh RSV-G is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 26.2 kDa. The predicted N-terminus is His 67. The reducing (R) protein migrates as 60-94 kDa in SDS-PAGE due to glycosylation.
- Purity
- >90 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
-
-
IGF1R is an entry receptor for respiratory syncytial virus." in: Nature, Vol. 583, Issue 7817, pp. 615-619, (2020) (PubMed).
: "
-
IGF1R is an entry receptor for respiratory syncytial virus." in: Nature, Vol. 583, Issue 7817, pp. 615-619, (2020) (PubMed).
-
- Target
- Glycoprotein / GP (Virus)
- Target Type
- Viral Protein
- Background
- Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. Human respiratory syncytial virus A (strain Long) major surface glycoprotein G (RSV-G), a member of the pneumoviruses glycoprotein G family, is also known as attachment glycoprotein G and membrane-bound glycoprotein (mG), which contains a linear heparin binding domain essential for virus attachment to the host. Concretely speaking, RSV-G can attache the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Furthermore, RSV-G can also interact with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, RSV-G lacks both neuraminidase and hemagglutinating activities.
- Molecular Weight
- 27.0 kDa
- UniProt
- P20895
-