PD-L1 Protein (mFc-His Tag)

Catalog No. ABIN6961096

Product Details

Target: PD-L1 (CD274 (PD-L1))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This PD-L1 protein is labelled with mFc-His Tag.

Application: ELISA

Purpose: Recombinant human PD-L1 protein with C-terminal mouse Fc and 6xHis tag

Specificity: PD-L1 (Phe19-Arg238) mFc (Pro99-Lys330) 6xHis tag

Characteristics: Extracellular Domain Protein

Purification: affinity purification

Purity: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Preservative: Without preservative

Storage: -20 °C,-80 °C

Expiry Date: 12 months

Target Details

Target: PD-L1 (CD274 (PD-L1))

Alternative Name: PD-L1 (PD-L1 Products)

Synonyms: B7-H Protein, B7H1 Protein, PD-L1 Protein, PDCD1L1 Protein, PDCD1LG1 Protein, PDL1 Protein, A530045L16Rik Protein, B7h1 Protein, Pdcd1l1 Protein, Pdcd1lg1 Protein, Pdl1 Protein, RGD1566211 Protein, CD274 molecule Protein, CD274 antigen Protein, programmed cell death 1 ligand 2 Protein, CD274 Protein, Cd274 Protein, PDCD1LG2 Protein

Background: Synonymes: PD-L1, CD274, B7-H1, PDCD1L1, PDCD1LG1
Description: This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.

Molecular Weight: predicted molecular mass of 52.3 kDa after removal of the signal peptide.

Gene ID: 29126

UniProt: Q9NZQ7

Pathways: Cancer Immune Checkpoints