CDCP1 Protein (Fc Tag)

Catalog No. ABIN7320042

Product Details

Target: CDCP1 (CUB Domain Containing Protein 1 (CDCP1))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This CDCP1 protein is labelled with Fc Tag.

Purpose: Recombinant Mouse CDCP1/CD318 Protein (Fc Tag)

Sequence: Met1-Leu666

Characteristics: A DNA sequence encoding the mouse CDCP1 (Q5U462) (Met1-Leu666) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Purity: > 79 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CDCP1 (CUB Domain Containing Protein 1 (CDCP1))

Alternative Name: CDCP1/CD318 (CDCP1 Products)

Synonyms: CD318 Protein, SIMA135 Protein, TRASK Protein, 9030022E12Rik Protein, AA409659 Protein, E030027H19Rik Protein, RGD1305578 Protein, zgc:113071 Protein, CUB domain containing protein 1 Protein, CUB domain containing protein 1a Protein, CDCP1 Protein, Cdcp1 Protein, cdcp1a Protein

Background:

Background: CDCP1 contains three extracellular CUB domains. It is a putative stem cell marker that is highly expressed in some human cancer cells and in both, typical and atypical (cancerous) colons. It interacts with CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4 and the serine protease ST14/MT-SP1. It also interacts with SRC and PRKCG/protein kinase C gamma. CDCP1 is taken as a key regulator of EGF/EGFR-induced cell migration. It has been shown that signaling via EGF/EGFR induces migration of ovarian cancer Caov3 and OVCA420 cells with concomitant up-regulation of CDCP1 mRNA and protein. Consistent with a role in cell migration CDCP1 relocates from cell-cell junctions to punctate structures on filopodia after activation of EGFR. It may be involved in cell adhesion and cell matrix association. It also may play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. It has been taken as a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets.

Synonym: 9030022E12Rik,AA409659,E030027H19Rik

Molecular Weight: 98.8 kDa

UniProt: Q5U462