DDR1 Protein (GST tag,His tag)

Catalog No. ABIN7317090

Product Details

Target: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: Baculovirus infected Insect Cells

Purification tag / Conjugate: This DDR1 protein is labelled with GST tag,His tag.

Purpose: Recombinant Human DDR1 Kinase/MCK10 Protein (aa 444-913, His & GST Tag)(Active)

Sequence: Arg444-Val913

Characteristics: A DNA sequence encoding the human DDR1 (Q08345-1) (Arg444-Val913) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Purity: > 89 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: The specific activity was determined to be 2.75 nmol/min/mg using synthetic AXLtide peptide(CKKSRGDYMTMQIG) as substrate.

Application Details

Comment:

80 kDa

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol, 3 mM DTT

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Alternative Name: MCK10 (DDR1 Products)

Synonyms: CG11573 Protein, CG13984 Protein, CG13985 Protein, CG33531 Protein, CG9488 Protein, CG9490 Protein, CT33540 Protein, DDR Protein, Dmel\\CG33531 Protein, Dmel_CG13984 Protein, 6030432F18 Protein, AI323681 Protein, CD167a Protein, Cak Protein, Nep Protein, PTK3A Protein, CAK Protein, CD167 Protein, EDDR1 Protein, HGK2 Protein, MCK10 Protein, NEP Protein, NTRK4 Protein, PTK3 Protein, RTK6 Protein, TRKE Protein, Drd1 Protein, PTK3D Protein, Discoidin domain receptor Protein, discoidin domain receptor family, member 1 Protein, discoidin domain receptor tyrosine kinase 1 Protein, Ddr Protein, Ddr1 Protein, DDR1 Protein

Background:

Background: Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of DDR1/MCK10/CD167 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. DDR1/MCK10/CD167 plays an important role in regulating attachment to collagen, chemotaxis, proliferation, and MMP production in smooth muscle cells. DDR1 functions in a feedforward loop to increase p53 levels and at least some of its effectors. Inhibition of DDR1 function resulted in strikingly increased apoptosis of wild-type p53-containing cells in response to genotoxic stress through a caspase-dependent pathway.

Synonym: CAK,CD167,DDR,EDDR1,HGK2,MCK10,NEP,NTRK4,PTK3,PTK3A,RTK6,TRKE

Molecular Weight: 80 kDa

Pathways: RTK Signaling, Smooth Muscle Cell Migration