DDR1 Protein (AA 22-415) (His tag)
-
- Target See all DDR1 Proteins
- DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 22-415
-
Origin
- Mouse
-
Source
- HEK-293 Cells
- Purification tag / Conjugate
- This DDR1 protein is labelled with His tag.
- Purpose
- Mouse DDR1 Protein
- Sequence
- Asp22-Ala415
- Characteristics
- Recombinant Mouse DDR1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Asp22-Ala415.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Top Product
- Discover our top product DDR1 Protein
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
-
- Target
- DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))
- Alternative Name
- DDR1 (DDR1 Products)
- Synonyms
- CG11573 Protein, CG13984 Protein, CG13985 Protein, CG33531 Protein, CG9488 Protein, CG9490 Protein, CT33540 Protein, DDR Protein, Dmel\\CG33531 Protein, Dmel_CG13984 Protein, 6030432F18 Protein, AI323681 Protein, CD167a Protein, Cak Protein, Nep Protein, PTK3A Protein, CAK Protein, CD167 Protein, EDDR1 Protein, HGK2 Protein, MCK10 Protein, NEP Protein, NTRK4 Protein, PTK3 Protein, RTK6 Protein, TRKE Protein, Drd1 Protein, PTK3D Protein, Discoidin domain receptor Protein, discoidin domain receptor family, member 1 Protein, discoidin domain receptor tyrosine kinase 1 Protein, Ddr Protein, Ddr1 Protein, DDR1 Protein
- Background
- Discoidin domain receptor1 (DDR1) is a collagen activated receptor tyrosine kinase and an attractive anti-fibrotic target. Its expression is mainly limited to epithelial cells located in several organs including skin, kidney, liver and lung. DDR1's biology is elusive, with unknown downstream activation pathways, however, it may act as a mediator of the stromal-epithelial interaction, potentially controlling the activation state of the resident quiescent fibroblasts.
- Molecular Weight
- 44.9 kDa. Due to glycosylation, the protein migrates to 60-65 kDa based on Tris-Bis PAGE result.
- Pathways
- RTK Signaling, Smooth Muscle Cell Migration
-