CD51/CD61 Protein (AA 31-988) (His tag)

Catalog No. ABIN7275073

Product Details

Target: CD51/CD61 (ITGAV/ITGB3) (Integrin AlphaV, Integrin Beta3 (ITGAV/ITGB3))

Protein Type: Recombinant

Protein Characteristics: AA 31-988

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This CD51/CD61 protein is labelled with His tag.

Purpose: Mouse Integrin alpha V beta 3 (ITGAV & ITGB3) Heterodimer Protein

Sequence: Phe31-Val988 (ITGAV) acidic tail & Glu26-Asp717 (ITGB3) basic tail

Specificity: Uni-Prot: P43406 (ITGAV), O54890 (ITGB3)

Characteristics: Recombinant Mouse Integrin alpha V beta 3 (ITGAV & ITGB3) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe31-Val988(ITGAV) acidic tail & Glu26-Asp717(ITGB3) basic tail.

Purity: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: CD51/CD61 (ITGAV/ITGB3) (Integrin AlphaV, Integrin Beta3 (ITGAV/ITGB3))

Alternative Name: Integrin alpha V beta 3 (ITGAV & ITGB3) Heterodimer (ITGAV/ITGB3 Products)

Synonyms: CD51 Protein, MSK8 Protein, VNRA Protein, VTNR Protein, integrin subunit alpha V Protein, ITGAV Protein

Background: ITGAV&ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV&ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV&ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV&ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV&ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling.

Molecular Weight: 131.48 kDa(ITGAV)&80.80 kDa(ITGB3). Due to enzyme lysis and glycosylation, the protein migrates to 90-130 kDa based on Tris-Bis PAGE result.

UniProt: P43406