PVRIG Protein (AA 35-165) (Fc-Avi Tag)
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- Target See all PVRIG Proteins
- PVRIG (Poliovirus Receptor-Related Immunoglobulin Domain Containing (PVRIG))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 35-165
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This PVRIG protein is labelled with Fc-Avi Tag.
- Purpose
- Mouse PVRIG Protein
- Sequence
- Ser35-Asp165
- Characteristics
- Recombinant Mouse PVRIG Protein is expressed from HEK293 with hFc tag and Avi tag at the C-Terminus.It contains Ser35-Asp165.
- Purity
- > 95 % as determined by Tris-Bis PAGE
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Mouse PVRIG, hFc Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Mouse Nectin-2, His Tag with the EC50 of 0.65ug/ml determined by ELISA. See testing image for detail.
- Top Product
- Discover our top product PVRIG Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- PVRIG (Poliovirus Receptor-Related Immunoglobulin Domain Containing (PVRIG))
- Alternative Name
- PVRIG (PVRIG Products)
- Synonyms
- C7orf15 Protein, PVR related immunoglobulin domain containing Protein, PVRIG Protein
- Background
- Murine PVRIG interacted weakly with poliovirus receptor (PVR) but bound poliovirus receptor-like 2 (PVRL2) strongly, making the latter its principal ligand.PVRIG is an inducible checkpoint receptor and that targeting PVRIG-PVRL2 interactions results in increased CD8+ T-cell function and reduced tumor growth.
- Molecular Weight
- 42.70 kDa. Due to glycosylation, the protein migrates to 53-63 kDa based on Tris-Bis PAGE result.
- UniProt
- A0A1B0GS01
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