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Human APOE Protein expressed in Human - ABIN934462
Krul, Cole: Quantitation of apolipoprotein E. in Methods in enzymology 1996
Human APOE Protein expressed in HEK-293 Cells - ABIN2714829
Pan, Zhou, Mahsut, Rohm, Berejnaia, Price, Chen, Castro-Perez, Lassman, McLaren, Conway, Jensen, Thomas, Reyes-Soffer, Ginsberg, Gutstein, Cleary, Previs, Roddy: Static and turnover kinetic measurement of protein biomarkers involved in triglyceride metabolism including apoB48 and apoA5 by LC/MS/MS. in Journal of lipid research 2016
TF overexpression enhanced plaque thrombogenicity, which played a pivotal role in atherothrombosis in ApoE-/- mice.
Impaired cognitive functions in female Arg-61 apoE mice appear correlated with larger GCL volume and higher calretinin-positive cell number and suggest a compensatory cellular response that may be related to amyloid beta perturbations early in life.
Mesenchymal stem cells-exosomes decrease the atherosclerotic plaque area in ApoE(-/-) mice and the infiltration of macrophages.
these results indicate that EZH2 inhibition promotes lipoprotein-dependent lipid accumulation via inducing ApoE expression in adipocytes, suggesting a novel mechanism of lipid regulation by EZH2.
A loss of a single Src family kinase, Fgr or Lyn, reduced platelet-mediated monocyte recruitment in vitro and a significant reduction in the burden of atherosclerotic disease in Fgr(-/-) /ApoE(-/-) or Lyn(-/-) /ApoE(-/-) animals.
there is a predilection of low protein C-induced spontaneous atherothrombosis in Apoe(-/-) mice for the right coronary sinus.
analysis of the APOE( *)3-Leiden.glucokinase(+/-) (E3L.GK(+/-)) mouse reveals that it is a model of metabolic syndrome and diabetic complications
chronic high-fat and high-cholesterol diet intake in a mouse model of atherosclerosis (ApoE-/-) decreases the level of ceramides and glucosylceramide.
AnxA5 treatment attenuates the post-ischemic inflammatory response and ameliorates LV remodeling which improves cardiac function three weeks after MI-R injury in hypercholesterolemic ApoE*3-Leiden mice.
Here we report that Cnn2 KO also decreased calcification of the aortic valve in ApoE KO mice, an established model of Calcific aortic valve disease
ApoE role in the hepatic bile acid homeostasis.
aged females demonstrated a significant exacerbation of many of these shared transcripts in this APOE network, revealing a potential mechanism for increased AD susceptibility in females. This study has broad implications for microglial transcriptomic approaches and provides new insights into microglial pathways associated with different pathological aspects of aging and AD.
Augmentation of intracellular adenosine levels through ADK knockout in myeloid cells protects ApoE(-/-) mice against atherosclerosis by reducing foam cell formation via the epigenetic regulation of cholesterol trafficking.
ApoE and Fasl(gld) knockout C57BL/6 mice simultaneously exhibited systemic lupus erythematosus and atherosclerosis characteristics and endothelial cell injury.
Immune activation in response to hyperlipidemia in ApoE knockout mice could contribute to a wide range of inflammatory autoimmune diseases, including atherosclerosis.
These data point to up-regulation of endothelial BKCa channels and CB2 receptors in ApoE(-/-) arteries.
the potential function of Pin1 in smooth muscle cells (SMCs) and its contribution to abdominal aortic aneurysm (AAA) pathogenesis in ApoE(-/-) mice, was examined.
PSRC1 protects against the development of atherosclerosis and enhances the stability of plaques by modulating cholesterol transportation and inflammation in macrophages and the liver of apoE(-/-) mice.
our results in this study suggest that ApoE4 genotype specific PIP2 dyshomeostasis contributes to the development of Tau hyper-phosphorylation after blast TBI exposure, and that elevation of brain PIP2 levels by reducing synj1 expression may ameliorate TBI- associated Tauopathy in ApoE4 carriers.
Dietary fat modulates osteoblastic, osteoclastic,and lipoblastic differentiation, and activity in a background of AlphaPOE deficiency.
Cerebral amyloid angiopathy-related vasculopathic changes and fragility associated with APOE epsilon2+ allele might have a biologically meaningful role in the pathophysiology and severity of cortical superficial siderosis.[Meta-Analysis]
Both candidate-gene studies and genome-wide analysis reveal APOE involvement in the attainment of an extreme lifespan by exerting a pleiotropic effect in a polygenic context. [review]
we confirm association of the APOE epsilon4 allele with increased risk for Lewy body dementia, and importantly demonstrate that APOE epsilon2 reduces risk of this disease.
Older men with APOE4 allele may be more vulnerable to postoperative cognitive dysfunction than older women with APOE4 allele.
A significant association between MMSE score and sex was observed in the lowest educational group, especially among carriers of APOE rs405509 TT genotypes.
There were significant associations between APOE [epsilon]4 and worse cognitive abilities, independent of potential confounders, and between lifestyle risk factors and worse cognitive abilities; however, there were no interactions.
This study concluded that the variation of the APOE gene may not influence familial longevity status at a certain age but the moderate-high HDL-C level contributes to the familial longevity in Bama.
The genotypes of TT in MTHFR C667T and epsilon4+in APOE may increase the severity of Coronary Artery Disease in a Chinese Han population, and higher Hcy, LDL-C, and ApoE levels may be involved in this pathogenic process.
Results indicate the age- and gender-specific reference intervals (RIs) of serum apolipoprotein E (Apo E) in healthy Chinese Han adults.
Consistent with previous reports, rs429358 (apolipoprotein E (ApoE) epsilon4) is associated with lower odds of surviving to the 90th and 99th percentile age, while rs7412 (ApoE epsilon2) shows the opposite. [Meta-analysis]
It was concluded that lower circulating retinol and higher alpha-tocopherol (TOH)/retinol ratio potentially predicts an increased risk for the development of cognitive decline in aging Chinese adults. ApoE2 or E4 carriers with higher circulating alpha-TOH/retinol ratio infer poor cognitive performance and an increased risk of developing MCI.
APOE-epsilon4 carriers which in itself may portend a faster decline in connectivity over the lifespan and ultimately trigger early amyloid-beta deposition in later life and have risk for Alzheimer's disease.
both b APOE gene allele plays beneficial and detrimental roles in cognition of healthy older people.
APOE locus may be linked with dementia risk.
Genetic variability in the APOE locus contribute to Alzheimer's disease pathogenesis.
ApoE and apoCIII on HDL interact to affect metabolism and coronary heart disease (CHD). ApoE promotes metabolic steps in reverse cholesterol transport and is associated with lower risk of CHD. ApoCIII, when coexisting with apoE on HDL, abolishes these benefits. Therefore, differences in metabolism of HDL subspecies pertaining to reverse cholesterol transport are reflected in differences in association with CHD.
astrocytes expressing E4 accumulate significantly more and smaller lipid droplets compared to E3 astrocytes.
The results showed that the APOE 3 allele was a protective factor for PD [ Parkinson disease ](OR = 0.90, 95% CI: 0.81-0.99; P = .04), whereas no significant differences in PD risk among all cases compared to controls were found for APOE 2 and 4. In Asian subgroups, the APOE 4 allele was shown to be a risk factor for PD [ Parkinson disease ]
Lipoprotein glomerulopathy (LPG)-associated apoE3 mutations R25C, R114C, and A152D induce protein misfolding, which may contribute to protein aggregation in glomerular capillaries. The thermodynamic destabilization and enhanced aggregation of both proline and non-proline mutations may constitute a common underlying mechanism behind the pathogenesis of LPG.
we report the efficient creation of an APOE knockout rabbit by using zinc finger nucleases. The knockout rabbits had drastically elevated cholesterol and moderately increased triglyceride levels, mimicking symptoms in human heart disease.
These differentially expressed proteins associated with key mechanisms involved in atherosclerosis and signaling mechanisms related with vitamin E.
The molar ratio ApoE/ApoA-I is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.
ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL paraoxonase activity
The identification of disulphide-linked apoE dimers in cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences.
These data suggest that the -155T>A mutation in the promoter region of the porcine APOE gene is an important functional variant
Nonesterified fatty acids significantly inhibit the expression of ApoB100, ApoE, MTP, and LDLR, thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
Bovine apoE contents in triglyceride-rich lipoproteins are modulated by nutritional treatment and closely associated with triglyceride-rich lipoprotein metabolism
apoE-containing particles, which increased during the lactating stage, were not associated with HDL particles, and lipid-free forms were included in cow plasma
after calving the apolipoprotein B(100) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP) and apolipoprotein E messenger RNA abundance were higher in the liver
The study found no coding variation within and between chimpanzee populations, suggesting that the maintenance of functionally diverse APOE polymorphisms is a unique feature of human evolution.
ApoE evolution and very likely the evolution of other apolipoproteins are influenced by feeding environment and diet of humans, chimpanzees and various other species.
In the hippocampus APOE protein levels were higher in good spatial performers than poor spatial performers animals
Allele frequencies of the ApoE gene found show that allele epsilon3 has one of the highest frequencies and epsilon4 allele one of the lowest compared to other population groups in the world
There was significantly more apoE immunoreactivity in the prefrontal cortex and hippocampus of aged animals compared to adult or middle-aged animals.
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
, apolipoprotein E3