|Antigen||Glutamate Receptor, Metabotropic 5 (GRM5) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This Metabotropic Glutamate Receptor 5 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Product Details anti-Metabotropic Glutamate Receptor 5 AntibodyTarget Details Metabotropic Glutamate Receptor 5 Application Details Handling Images
|Specificity||This antibody detects endogenous levels of mGluR5 / GRM5 protein (region surrounding Lys56).|
Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.
|Plasmids, Primers & others|
Target Details Metabotropic Glutamate Receptor 5Product Details anti-Metabotropic Glutamate Receptor 5 Antibody Application Details Handling Images back to top
|Alternative Name||mGluR5 / GRM5 (GRM5 Antibody Abstract)|
|Background||The mGluR proteins (metabotropic glutamate receptors) are members of the G protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic glutamate receptors). The eight currently known mGluR proteins are mediated by two G proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR-1 and mGluR-5 are mediated by a G protein that activates a phosphatidylinositolcalcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight subtypes of mGluR have an activity mediated by a G protein that inhibits adenylate cyclase activity. mGluR-3, which may interact with GRASP, acts as a receptor for glutamate.Synonyms: GPRC1E, MGLUR5, Metabotropic glutamate receptor 5|
|Molecular Weight||approx. 132 kDa|
|Pathways||Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity|
Application DetailsProduct Details anti-Metabotropic Glutamate Receptor 5 Antibody Target Details Metabotropic Glutamate Receptor 5 Handling Images back to top
ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Metabotropic Glutamate Receptor 5 Antibody Target Details Metabotropic Glutamate Receptor 5 Application Details Images back to top
|Buffer||Phosphate buffered saline (PBS), pH 7.2., 0.05 % Sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
ImagesProduct Details anti-Metabotropic Glutamate Receptor 5 Antibody Target Details Metabotropic Glutamate Receptor 5 Application Details Handling back to top