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The urea transporter subtypes, UT-A1 and UT-B1 (show SLC14A1 Antibodies), were expressed in the skin basal cell layer and exocrine sweat glands. The abundance of UT-A1 and UT-B1 (show SLC14A1 Antibodies) in uremic sweat glands was significantly increased in UP, while the expression of AQP5 (show AQP5 Antibodies) was decreased.
UT2 is a negative regulator shared across STAT3 (show STAT3 Antibodies) and mTORC2 (show CRTC2 Antibodies) signaling cascades, functioning as a tumor suppressor in hematologic malignancies driven by those pathways.
Studies indicate that the urea transporter SLC14a2, the UT-A group, was originally isolated from kidney inner medulla.
Studies indicate that the cell signaling pathway for vasopressin (show AVP Antibodies)-mediated urea transporters phosphorylation and activity involves two cAMP-dependent signaling pathways.
HUT2 gene may play a certain role in developing metabolic syndrome and its related traits in Asian population.
results provide new evidences that suggest the involvement of AQP9 (show AQP7 Antibodies) and UT-A in the urea excretion mechanism across human term placenta from mother to fetus in physiological conditions
polymorphisms in the SLC14A2 gene can predict the antihypertensive efficacy of nifedipine GITS (gastrointestinal therapeutic system)
results suggest that GSK3 may in part modulate the hypertonic-induced intracellular UT-A1 redistribution and its accumulation on the plasma membrane, which may constitute another mechanism by which GSK3 modulates urine concentration
Studies indicate that urea transporter Slc14a2 (UT-A1/3) knockout mouse models showed the essential role of urea for producing maximally concentrated urine.
It is concluded that NaCl and urea synergistically induce the expression of UTA2 rather than AQP2 (show AQP2 Antibodies) in mIMCD3 cells, and hyperosmolality probably mediates the expression of AQP2 (show AQP2 Antibodies) and UTA2 through different mechanisms.
These results suggest that in wild-type mice UT-A2 facilitates urea absorption by urea efflux from the thin descending limb of short loops of Henle.
Levels of UTA mRNA were increased in thirsted mice compared with control animals
potassium depletion is associated with reduced expression of UT-A1, UT-A3, and UT-B (show SLC14A1 Antibodies) but increased expression of UT-A2.
mUT (show MUT Antibodies)-A3 is a basolateral membrane transporter expressed in inner medullary collecting duct cells.
lack of UT-B (show SLC14A1 Antibodies) does not result in a change in expression of urea transporters involved in urea reabsorption from the inner medullary collecting duct (UT-A1 and UT-A3).
UT-A2 is important for maintaining a high concentration of urea in the inner medulla when urea supply to the kidney is limited
The protein encoded by this gene belongs to the urea transporter family. In mammalian cells, urea is the chief end product of nitrogen catabolism, and plays an important role in the urinary concentration mechanism. This protein is expressed in the inner medulla of the kidney, and mediates rapid transepithelial urea transport across the inner medullary collecting duct. Alternatively spliced transcript variants have been found for this gene.
solute carrier family 14 (urea transporter), member 2
, urea transporter 2-like
, solute carrier family 14 member 2
, urea transporter 2
, urea transporter, kidney
, urea transporter-2
, plasma membrane urea transporter
, solute carrier family 14 (urea transporter), member 2, variant 4
, solute carrier family 14 (urea transporter), member 2T
, solute carrier family 14, member 2
, urea transport protein
, vasopressin-regulated urea transporter