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The urea transporter subtypes, UT-A1 and UT-B1, were expressed in the skin basal cell layer and exocrine sweat glands. The abundance of UT-A1 and UT-B1 in uremic sweat glands was significantly increased in UP, while the expression of AQP5 was decreased.
UT2 is a negative regulator shared across STAT3 and mTORC2 signaling cascades, functioning as a tumor suppressor in hematologic malignancies driven by those pathways.
Studies indicate that the urea transporter SLC14a2, the UT-A group, was originally isolated from kidney inner medulla.
Studies indicate that osmotic diuresis, where urea concentrations are low, can prompt an increase in urea transporter abundance.
Studies indicate that the cell signaling pathway for vasopressin-mediated urea transporters phosphorylation and activity involves two cAMP-dependent signaling pathways.
HUT2 gene may play a certain role in developing metabolic syndrome and its related traits in Asian population.
a novel UT-A urea transporter; the transcript contains a novel 129-bp exon, exon 5a, which, as a result of alternative splicing, introduces a unique 19-aa segment and a stop codon.
results provide new evidences that suggest the involvement of AQP9 and UT-A in the urea excretion mechanism across human term placenta from mother to fetus in physiological conditions
This review summarizes the published work that has accrued on the structure and regulation of these genes.
polymorphisms in the SLC14A2 gene can predict the antihypertensive efficacy of nifedipine GITS (gastrointestinal therapeutic system)
Functional deficiency of all UTs caused a urea-selective urine-concentrating defect with little physiological abnormality in extrarenal organs.
results suggest that GSK3 may in part modulate the hypertonic-induced intracellular UT-A1 redistribution and its accumulation on the plasma membrane, which may constitute another mechanism by which GSK3 modulates urine concentration
Studies indicate that urea transporter Slc14a2 (UT-A1/3) knockout mouse models showed the essential role of urea for producing maximally concentrated urine.
It is concluded that NaCl and urea synergistically induce the expression of UTA2 rather than AQP2 in mIMCD3 cells, and hyperosmolality probably mediates the expression of AQP2 and UTA2 through different mechanisms.
These results suggest that in wild-type mice UT-A2 facilitates urea absorption by urea efflux from the thin descending limb of short loops of Henle.
Levels of UTA mRNA were increased in thirsted mice compared with control animals
potassium depletion is associated with reduced expression of UT-A1, UT-A3, and UT-B but increased expression of UT-A2.
mUT-A3 is a basolateral membrane transporter expressed in inner medullary collecting duct cells.
lack of UT-B does not result in a change in expression of urea transporters involved in urea reabsorption from the inner medullary collecting duct (UT-A1 and UT-A3).
UT-A2 is important for maintaining a high concentration of urea in the inner medulla when urea supply to the kidney is limited
These results demonstrate that 4.2 kb of the UT-Aalpha promoter is sufficient to drive expression of a heterologous reporter gene in a tissue-specific and cell-specific fashion in transgenic mice.
Urea transporter UT-A2 is acutely sensitive to AVP, cAMP, or increased intracellular calcium.
data suggest that the Gamble phenomenon is largely a manifestation of facilitated urea transport in the inner medulla collecting dut by UT-A1 and UT-A3
UT-A1 is a target gene of KLF12.
results indicate that UT-A3 is acutely regulated by arginine vasopressin, via a protein kinase A-dependent pathway in MDCK type I cells
Biophysical characterization of mouse UT-A2 and UT-A3 undertaken by expression in Xenopus laevis oocytes and preparation of plasma membrane vesicles for use in stopped-flow fluorometry.
ubiquitination regulates the plasma membrane expression of all three major UT-A urea transporters, but that this is not the mechanism primarily used by vasopressin to produce its physiological effects.
Three distinct variations in the appearance of the renal pelvis were found in UT-A1/3(-/-) mice
study investigated the vasopressin regulation of the basolateral urea transporter UT-A3 using an MDCK-mUT-A3 cell line; vasopressin significantly increases UT-A3 localization at the basolateral membrane
The protein encoded by this gene belongs to the urea transporter family. In mammalian cells, urea is the chief end product of nitrogen catabolism, and plays an important role in the urinary concentration mechanism. This protein is expressed in the inner medulla of the kidney, and mediates rapid transepithelial urea transport across the inner medullary collecting duct. Alternatively spliced transcript variants have been found for this gene.
solute carrier family 14 (urea transporter), member 2
, urea transporter 2-like
, solute carrier family 14 member 2
, urea transporter 2
, urea transporter, kidney
, urea transporter-2
, plasma membrane urea transporter
, solute carrier family 14 (urea transporter), member 2, variant 4
, solute carrier family 14 (urea transporter), member 2T
, solute carrier family 14, member 2
, urea transport protein
, vasopressin-regulated urea transporter