anti-Rat (Rattus) Phospholipase C gamma 2 antibody for Immunohistochemistry

Recommended Phospholipase C gamma 2 Antibody (supplied by: Log in to see )

Antigen
Phospholipase C gamma 2 (PLCG2) Antibodies
  • PLCgamma2
  • Plcg-2
  • APLAID
  • FCAS3
  • phospholipase C, gamma 2
  • phospholipase C gamma 2
  • phospholipase C, gamma 2 (phosphatidylinositol-specific)
  • Plcg2
  • PLCG2
Reactivity
Mouse (Murine), Rat (Rattus), Human
285
173
162
12
4
4
4
4
3
1
Host
Rabbit
233
52
Clonality
Polyclonal
Conjugate
This Phospholipase C gamma 2 antibody is un-conjugated
6
6
5
5
5
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
206
110
63
60
44
40
36
16
14
10
3
3
2
1
Options
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Catalog No. ABIN3023145
$ 393.25
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
19.034317 ABIN5692854 ELISA IHC WB Rabbit AA 1201-1258 Log in to see Polyclonal 0
17.575418 ABIN966863 IHC Rabbit Log in to see Polyclonal 2
16.075418 ABIN3186506 ELISA IHC WB Rabbit IgG Thr246 Log in to see Polyclonal 0
16.075418 ABIN3182494 ELISA IHC WB Rabbit IgG pTyr753 Log in to see Polyclonal 0
16.034317 ABIN6256017 ELISA ICC IF IHC WB Rabbit IgG pTyr753 Log in to see Polyclonal 0
16.034317 ABIN6264289 ELISA ICC IF IHC WB Rabbit IgG Log in to see Polyclonal 0
13.075418 ABIN3186505 ELISA IHC WB Rabbit IgG Thr2446 Log in to see Polyclonal 0
13.075418 ABIN3182765 ELISA IF IHC WB Rabbit IgG pTyr1217 Log in to see Polyclonal 0
13.075418 ABIN966862 IHC Rabbit pTyr753 Log in to see 4
13.075418 ABIN1842540 IHC Rabbit IgG pTyr1217 Log in to see Polyclonal 0
13.075418 ABIN2149244 IHC ELISA WB Rabbit IgG pTyr753 Log in to see Polyclonal 0
13.034317 ABIN1531375 IF IHC ELISA WB Rabbit IgG AA 1186-1235, pTyr1217 Log in to see Polyclonal 0
13.034317 ABIN6269889 ELISA IHC WB Rabbit IgG pTyr1245 Log in to see Polyclonal 0
13.034317 ABIN6264290 ELISA ICC IF IHC WB Rabbit IgG Log in to see Polyclonal 0
13.034317 ABIN1874161 IF IHC IP WB Rabbit IgG Log in to see Polyclonal 0
10.034317 ABIN2706830 IHC WB Rabbit Center Log in to see Polyclonal 0
10.034317 ABIN2706829 IHC WB Rabbit pTyr753 Log in to see Polyclonal 0
10.034317 ABIN2705143 IHC WB Rabbit C-Term Log in to see Polyclonal 0
10.034317 ABIN1531237 IHC ELISA WB Rabbit IgG AA 721-770, pTyr753 Log in to see Polyclonal 1
10.034317 ABIN1532255 IHC ELISA WB Rabbit IgG AA 721-770 Log in to see Polyclonal 0

General

Antigen Phospholipase C gamma 2 (PLCG2) Antibodies
Reactivity Mouse (Murine), Rat (Rattus), Human
(285), (173), (162), (12), (4), (4), (4), (4), (3), (1)
Host Rabbit
(233), (52)
Clonality
Polyclonal
Conjugate This Phospholipase C gamma 2 antibody is un-conjugated
(6), (6), (5), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application Immunohistochemistry (IHC), Western Blotting (WB)
(206), (110), (63), (60), (44), (40), (36), (16), (14), (10), (3), (3), (2), (1)
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Product Details anti-Phospholipase C gamma 2 Antibody

Target Details Phospholipase C gamma 2 Application Details Handling Images
Purification Affinity purification
Immunogen Recombinant protein of human PLCG2
Isotype IgG
Plasmids, Primers & others

Target Details Phospholipase C gamma 2

Product Details anti-Phospholipase C gamma 2 Antibody Application Details Handling Images back to top
Antigen
Alternative Name PLCG2 (PLCG2 Antibody Abstract)
Background Phosphoinositide-specific phospholipase C (PLC) plays a significant role in transmembrane signaling. In response to extracellular stimuli such as hormones, growth factors and neurotransmitters, PLC hydrolyzes phosphatidylinositol 4, 5-bisphosphate (PIP2) to generate two secondary messengers: inositol 1, 4, 5-triphosphate (IP3) and diacylglycerol (DAG). At least four families of PLCs have been identified: PLCbeta, PLCgamma, PLCdelta and PLCepsilon. The PLCbeta subfamily includes four members, PLCbeta1-4. All four members of the subfamily are activated by alpha- or beta-gamma-subunits of the heterotrimeric G-proteins.Phosphorylation is one of the key mechanisms that regulates the activity of PLC. Phosphorylation of Ser1105 by PKA or PKC inhibits PLCbeta3 activity. Ser537 of PLCbeta3 is phosphorylated by CaMKII, and this phosphorylation may contribute to the basal activity of PLCbeta3. PLCgamma is activated by both receptor and nonreceptor tyrosine kinases.PLCgamma forms a complex with EGF and PDGF receptors, which leads to the phosphorylation of PLCgamma at Tyr771, 783 and 1245. Phosphorylation by Syk at Tyr783 activates the enzymatic activity of PLCgamma1. PLCgamma2 is engaged in antigen-dependent signaling in B cells and collagen-dependent signaling in platelets. Phosphorylation by Btk or Lck at Tyr753, 759, 1197 and 1217 is correlated with PLCgamma2 activity.
Synonyms: PLCG2, APLAID, FCAS3
Gene ID 5336
UniProt P16885
Pathways RTK Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway, Inositol Metabolic Process, Myometrial Relaxation and Contraction, Toll-Like Receptors Cascades, VEGF Signaling

Application Details

Product Details anti-Phospholipase C gamma 2 Antibody Target Details Phospholipase C gamma 2 Handling Images back to top
Application Notes Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200
Restrictions For Research Use only

Handling

Product Details anti-Phospholipase C gamma 2 Antibody Target Details Phospholipase C gamma 2 Application Details Images back to top
Format Liquid
Buffer PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze / thaw cycles
Storage -20 °C/-80 °C

Images

Product Details anti-Phospholipase C gamma 2 Antibody Target Details Phospholipase C gamma 2 Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Phospholipase C gamma 2 (PLCG2) antibody (ABIN3023145) anti-Phospholipase C gamma 2 (PLCG2) antibody
Immunofluorescence (IF) image for anti-Phospholipase C gamma 2 (PLCG2) antibody (ABIN3023145) Immunofluorescence analysis of HeLa cell using PLCG2 antibody.
Western Blotting (WB) image for anti-Phospholipase C gamma 2 (PLCG2) antibody (ABIN3023145) Western blot analysis of extracts of various cell lines, using PLCG2 antibody.
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Phospholipase C gamma 2 (PLCG2) antibody (ABIN3023145) Immunohistochemistry of paraffin-embedded mouse heart using PLCG2 antibody.
Immunofluorescence (IF) image for anti-Phospholipase C gamma 2 (PLCG2) antibody (ABIN3023145) Immunofluorescence analysis of U2OS cells using PLCG2 antibody.