anti-Human TRKA antibody for Neutralization

Recommended TRKA Antibody (supplied by: Log in to see )

Antigen
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) Antibodies
  • MTC
  • TRK
  • TRK1
  • TRKA
  • Trk-A
  • p140-TrkA
  • Trk
  • C80751
  • Tkr
  • TrkA
  • trk
  • trka
  • CTRKA
  • trkA
  • neurotrophic receptor tyrosine kinase 1
  • neurotrophic tyrosine kinase, receptor, type 1
  • NTRK1
  • Ntrk1
  • ntrk1
Epitope
AA 33-407
57
23
19
18
17
15
15
15
15
13
13
12
12
11
11
10
10
9
9
9
8
7
7
6
5
5
5
4
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
408
244
197
2
2
Host
Goat
373
62
4
3
Clonality
Polyclonal
Conjugate
This TRKA antibody is un-conjugated
16
15
15
10
9
9
9
8
8
8
8
7
7
7
7
7
6
2
2
2
2
1
Application
Cytometry by Time of Flight (CyTOF), Flow Cytometry (FACS), Immunohistochemistry (IHC), Neutralization (Neut), Western Blotting (WB)
256
144
88
86
57
54
53
40
18
11
5
5
4
2
1
Supplier
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Catalog No. ABIN4900238
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General

Antigen Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) Antibodies
Epitope AA 33-407
(57), (23), (19), (18), (17), (15), (15), (15), (15), (13), (13), (12), (12), (11), (11), (10), (10), (9), (9), (9), (8), (7), (7), (6), (5), (5), (5), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(408), (244), (197), (2), (2)
Host Goat
(373), (62), (4), (3)
Clonality
Polyclonal
Conjugate This TRKA antibody is un-conjugated
(16), (15), (15), (10), (9), (9), (9), (8), (8), (8), (8), (7), (7), (7), (7), (7), (6), (2), (2), (2), (2), (1)
Application Cytometry by Time of Flight (CyTOF), Flow Cytometry (FACS), Immunohistochemistry (IHC), Neutralization (Neut), Western Blotting (WB)
(256), (144), (88), (86), (57), (54), (53), (40), (18), (11), (5), (5), (4), (2), (1)
Pubmed 5 references available
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Product Details anti-TRKA Antibody

Target Details TRKA Application Details Handling References for anti-TRKA antibody (ABIN4900238) Images
Specificity Detects human TrkA in direct ELISAs and Western blots. In direct ELISAs, approximately 50 % cross-reactivity with recombinant rat TrkA is observed and 10 % cross-reactivity with recombinant human (rh) TrkB and rhTrKC is observed.
Purification Antigen Affinity-purified
Sterility 0.2 μm filtered
Endotoxin Level <0.10 EU per 1 μg of the antibody by the LAL method.
Immunogen Mouse myeloma cell line NS0-derived recombinant human TrkA, Ala33-Glu407, Accession # AAA36770
Isotype IgG

Target Details TRKA

Product Details anti-TRKA Antibody Application Details Handling References for anti-TRKA antibody (ABIN4900238) Images back to top
Antigen
Alternative Name TrkA (NTRK1 Antibody Abstract)
Background Alternative Names: DKFZp781I14186, EC 2.7.10, EC 2.7.10.1, MTChigh affinity nerve growth factor receptor, Neurotrophic tyrosine kinase receptor type 1, neurotrophic tyrosine kinase, receptor, type 1, NTRK1, NTRK-1, p140-TrkA, TRK1-transforming tyrosine kinase protein, Trk-A, TRKAOncogene TRK, TRKTRK1, tyrosine kinase receptor A
Gene ID 4914
Pathways RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process

Application Details

Product Details anti-TRKA Antibody Target Details TRKA Handling References for anti-TRKA antibody (ABIN4900238) Images back to top
Application Notes Western Blot 1 μg/mL
Flow Cytometry 2.5 μg/10^6 cells
Immunohistochemistry 5-15 μg/mL
Neutralization 3-12 μg/mL
CyTOF-ready
Restrictions For Research Use only

Handling

Product Details anti-TRKA Antibody Target Details TRKA Application Details References for anti-TRKA antibody (ABIN4900238) Images back to top
Reconstitution Reconstitute at 0.2 mg/mL in sterile PBS.
Buffer Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Preservative Without preservative
Storage 4 °C,-20 °C,-80 °C
Storage Comment Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt,-20°C to -70°C as supplied. 1 month,2°C to 8°C under sterile conditions after reconstitution. 6 months,-20°C to -70°C under sterile conditions after reconstitution.
Expiry Date 12 months

References for anti-TRKA antibody (ABIN4900238)

Product Details anti-TRKA Antibody Target Details TRKA Application Details Handling Images back to top
Product cited in:

Prencipe, Minnone, Strippoli, De Pasquale, Petrini, Caiello, Manni, De Benedetti, Bracci-Laudiero: "Nerve growth factor downregulates inflammatory response in human monocytes through TrkA." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 7, pp. 3345-54, 2014 Method employed by authors: Neutralization (Neut) (Sample species: Human).

Flowerdew, Wick, Himmelein, Horn, Sinicina, Strupp, Brandt, Theil, Hüfner: "Characterization of neuronal populations in the human trigeminal ganglion and their association with latent herpes simplex virus-1 infection." in: PLoS ONE, Vol. 8, Issue 12, pp. e83603, 2013 Method employed by authors: Immunohistochemistry (IHC), Immunohistochemistry (IHC) (Sample species: Human).

Huang, Lai, Wu, Cheng, Chiu: "TrkB antibody elicits cytotoxicity and suppresses migration/invasion of transitional cell carcinoma cells." in: International journal of oncology, Vol. 37, Issue 4, pp. 943-9, 2010 Method employed by authors: Functional Studies (Func), Functional Studies (Func) (Sample species: Human).

Huang, Lai, Wu, Hsu, Cheng, Lan, Chiu: "BDNF mediated TrkB activation is a survival signal for transitional cell carcinoma cells." in: International journal of oncology, Vol. 36, Issue 6, pp. 1469-76, 2010 Method employed by authors: Immunocytochemistry (ICC), Immunocytochemistry (ICC) (Sample species: Human).

Sniderhan, Garcia-Bates, Burgart, Bernstein, Phipps, Maggirwar: "Neurotrophin signaling through tropomyosin receptor kinases contributes to survival and proliferation of non-Hodgkin lymphoma." in: Experimental hematology, Vol. 37, Issue 11, pp. 1295-309, 2009 Method employed by authors: Immunocytochemistry (ICC), Immunocytochemistry (ICC) (Sample species: Human).

Images

Product Details anti-TRKA Antibody Target Details TRKA Application Details Handling References for anti-TRKA antibody (ABIN4900238) back to top
Supplier Images
Neutralization (Neut) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 33-407) antibody (ABIN4900238) Cell Proliferation Induced by beta-NGF and Neutralization by Human TrkA Antibody. Rec...
Immunohistochemistry (IHC) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 33-407) antibody (ABIN4900238) TrkA in Human Colon. TrkA was detected in immersion fixed paraffin-embedded sections ...
Western Blotting (WB) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 33-407) antibody (ABIN4900238) Detection of Human TrkA by Western Blot. Western blot shows lysates of RPMI 8226 huma...