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RuvC Products

(Crossover Junction Endodeoxyribonuclease RuvC (RuvC))

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Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. {ECO:0000269|PubMed:1661673, ECO:0000269|PubMed:1758493}.

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Featured RuvC Categories

RuvC Antibodies

High quality antibodies with extensive validation data.

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Latest Publications for our RuvC products

Murayama, Kurokawa, Mayanagi, Iwasaki: "Formation and branch migration of Holliday junctions mediated by eukaryotic recombinases." in: Nature, Vol. 451, Issue 7181, pp. 1018-21, (2008) (PubMed).

Ichiyanagi, Iwasaki, Hishida, Shinagawa: "Mutational analysis on structure-function relationship of a holliday junction specific endonuclease RuvC." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 3, Issue 9, pp. 575-86, (1998) (PubMed).

Shinagawa, Iwasaki: "Processing the holliday junction in homologous recombination." in: Trends in biochemical sciences, Vol. 21, Issue 3, pp. 107-11, (1996) (PubMed).

Saito, Iwasaki, Ariyoshi, Morikawa, Shinagawa: "Identification of four acidic amino acids that constitute the catalytic center of the RuvC Holliday junction resolvase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 16, pp. 7470-4, (1995) (PubMed).

Iwasaki, Takahagi, Shiba, Nakata, Shinagawa: "Escherichia coli RuvC protein is an endonuclease that resolves the Holliday structure." in: The EMBO journal, Vol. 10, Issue 13, pp. 4381-9, (1992) (PubMed).

Synonyms and alternative names related to RuvC

Crossover junction endodeoxyribonuclease RuvC (ruvC), ECK1864, JW1852

Protein level used designations for RuvC

  • Holliday junction nuclease RuvC
  • Holliday junction resolvase RuvC
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