anti-Human CD4 antibody for Immunohistochemistry (Frozen Sections)

Recommended CD4 Antibody (supplied by: Log in to see )

Antigen
CD4 Molecule (CD4) Antibodies
  • cd4
  • L3T4
  • Ly-4
  • CD4mut
  • W3/25
  • p55
  • CD4 molecule
  • carcinoembryonic antigen-related cell adhesion molecule 5
  • T-cell surface glycoprotein CD4
  • CD4 antigen
  • Cd4 molecule
  • CD4
  • LOC100125525
  • cd4
  • Cd4
Reactivity
Human
1261
577
228
69
61
41
34
30
28
26
25
25
22
21
18
18
15
13
11
10
10
9
8
7
5
5
4
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
Host
Mouse
1323
517
306
13
4
2
1
1
Clonality
Monoclonal
Conjugate
This CD4 antibody is un-conjugated
247
216
153
127
41
40
38
32
30
29
29
25
24
20
16
15
15
15
15
15
15
14
14
13
10
10
9
8
8
8
8
7
7
6
5
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
1648
531
461
301
281
268
214
166
90
73
49
39
31
26
21
19
18
14
14
11
11
9
6
6
5
4
4
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
Options
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Catalog No. ABIN1042376
$ 383.89
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
17.57506 ABIN965795 IHC (fro) FACS Mouse IgG2a Log in to see B486 (EDU-2) 5
16.07506 ABIN5668252 FACS IHC IHC (fro) Rabbit IgG, kappa Log in to see Chimeric 0
16.07506 ABIN5668246 ELISA EIA FACS IHC (fro) WB Rabbit IgG, kappa Log in to see Chimeric 0
16.07506 ABIN5668251 FACS IHC IHC (fro) Rat IgG1, kappa Log in to see YNB46-1-8 (Campath-9H) 0
13.07506 ABIN965796 IHC (af) IHC (fro) FACS IF Mouse IgM Log in to see B379 (JOU 4B7F4) 3
13.07506 ABIN5668245 ELISA EIA FACS IHC (fro) WB Mouse IgG1, kappa Log in to see 13B8-2 0
13.07506 ABIN284266 FACS IHC (fro) ELISA Mouse IgG1 Log in to see QS4120 0
13.07506 ABIN2136539 IHC (fro) Mouse IgG1 Log in to see CA-4 0
13.07506 ABIN133265 FACS IHC (fro) FITC Rat IgG2a Log in to see CT-CD4 0
13.07506 ABIN1689482 IHC (fro) Mouse IgG1 Log in to see CA-4 0
13 ABIN3043630 IHC (fro) Mouse IgG1 Log in to see CA-4 6
8.5 ABIN2480254 IHC (fro) FACS Rat IgG1 Log in to see YNB46-1-8 2
8.5 ABIN2480187 IHC (fro) FACS Mouse IgG1 Log in to see RPA-T4 1
7.938506 ABIN4292796 BP FACS IHC IHC (fro) in vitro Neut Mouse IgG1 kappa Log in to see RPA-T4 12
6.438506 ABIN4292801 BP CyTOF FACS ICC IF IHC IHC (fro) Neut Mouse IgG1 kappa Log in to see RPA-T4 0
5.5 ABIN2480253 IHC (fro) FACS Rat IgG1 Log in to see YNB46-1-8 2
5.5 ABIN2480204 Func IHC (fro) FACS Mouse IgG1 Log in to see RPA-T4 1
4 ABIN118487 FACS IHC (fro) Mouse IgG1 Log in to see RPA-T4 2
4 ABIN120115 FACS IHC (fro) Rat IgG1 Log in to see YNB46-1-8 2
4 ABIN781715 IHC (fro) FACS Mouse IgG2a Log in to see EDU-2 1

General

Antigen CD4 Molecule (CD4) Antibodies
Reactivity Human
(1261), (577), (228), (69), (61), (41), (34), (30), (28), (26), (25), (25), (22), (21), (18), (18), (15), (13), (11), (10), (10), (9), (8), (7), (5), (5), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Host Mouse
(1323), (517), (306), (13), (4), (2), (1), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CD4 antibody is un-conjugated
(247), (216), (153), (127), (41), (40), (38), (32), (30), (29), (29), (25), (24), (20), (16), (15), (15), (15), (15), (15), (15), (14), (14), (13), (10), (10), (9), (8), (8), (8), (8), (7), (7), (6), (5), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(1648), (531), (461), (301), (281), (268), (214), (166), (90), (73), (49), (39), (31), (26), (21), (19), (18), (14), (14), (11), (11), (9), (6), (6), (5), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Pubmed 4 references available
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Product Details anti-CD4 Antibody

Target Details CD4 Application Details Handling References for anti-CD4 antibody (ABIN1042376) Images
Specificity CD4 (Edu-2) recognizes the CD4 antigen (a 55 kD glycoprotein).
Characteristics CD markers
Purification Purified
Clone Edu-2
Isotype IgG2a
Plasmids, Primers & others

Target Details CD4

Product Details anti-CD4 Antibody Application Details Handling References for anti-CD4 antibody (ABIN1042376) Images back to top
Antigen
Alternative Name CD4 (CD4 Antibody Abstract)
Background CD4 (Cluster of Differentiation 4) is a glycoprotein expressed on the surface of T helper cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 (after the OKT4 monoclonal antibody that reacted with it) before being named CD4 in 1984. In humans, the CD4 protein is encoded by the CD4 gene. CD4 plays a role in the recognition of foreign antigens presented to T cells by MHC class II molecules. Furthermore, this antigen acts as a receptor for HIV-1 by binding the viral protein gp120. The CD4 antigen is present on most thymocytes and a subpopulation of peripheral blood T cells, called T helper cells (Th). In addition, CD4 is expressed on monocytes and weak on macrophages.
Pathways TCR Signaling, Maintenance of Protein Location, CXCR4-mediated Signaling Events

Application Details

Product Details anti-CD4 Antibody Target Details CD4 Handling References for anti-CD4 antibody (ABIN1042376) Images back to top
Application Notes Flow cytometry and immunohistochemistry using frozen and paraffin embedded tissue sections. Optimal antibody dilution should be determined by titration. CD4 (Edu-2) is used in routine blood testing for CD4+ cells and CD4/CD8 ratios (e.g. HIV/AIDS patients) or as part of panels for the detection and differentiation of certain T cell leukemias. CD4 is also used in studies of functional activity of Th-cells in bacterial and viral infections, development of auto-immune diseases, transplant rejection, immune protection in response to allergens or allergenic reactivity.
Comment

Edu-2 is a mouse monoclonal IgG2a antibody raised against CD4.

Restrictions For Research Use only

Handling

Product Details anti-CD4 Antibody Target Details CD4 Application Details References for anti-CD4 antibody (ABIN1042376) Images back to top
Format Liquid
Concentration 100 µg/mL
Buffer 0.01 M sodium phosphate, 0.15 M NaCl, 0.2% BSA, 0.09% sodium azide, pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C

References for anti-CD4 antibody (ABIN1042376)

Product Details anti-CD4 Antibody Target Details CD4 Application Details Handling Images back to top
Product cited in:

Allison, Lanier: "Structure, function, and serology of the T-cell antigen receptor complex." in: Annual review of immunology, Vol. 5, pp. 503-40, 1987

Kaneoka, Perez-Rojas, Sasasuki, Benike, Engleman: "Human T lymphocyte proliferation induced by a pan-T monoclonal antibody (anti-Leu 4): heterogeneity of response is a function of monocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 131, Issue 1, pp. 158-64, 1983

Friedrich, OReilly, Koziner, Gebhard, Good, Evans: "T-lymphocyte reconstitution in recipients of bone marrow transplants with and without GVHD: imbalances of T-cell subpopulations having unique regulatory and cognitive functions." in: Blood, Vol. 59, Issue 4, pp. 696-701, 1982

Background publications

Lanier, Allison, Phillips: "Correlation of cell surface antigen expression on human thymocytes by multi-color flow cytometric analysis: implications for differentiation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 137, Issue 8, pp. 2501-7, 1986

Images

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Supplier Images
 image for anti-CD4 Molecule (CD4) antibody (ABIN1042376) anti-CD4 Molecule (CD4) antibody