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|Antigen||FYN-Binding Protein (FYB) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This FYB antibody is conjugated to HRP Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-FYB AntibodyTarget Details FYB Application Details Handling Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human FYB/ADAP|
Target Details FYBProduct Details anti-FYB Antibody Application Details Handling Images back to top
|Alternative Name||Fyb/Adap (FYB Antibody Abstract)|
Fyb (Fyn binding protein) and the anchoring proteins SKAP55 (src kinase-associated phosphoprotein) and SKAP55-R (SKAP55-related protein) associate with the tyrosine kinase p59fyn (1â€"3). SKAP55 and SKAP55-R bind to Fyb through their SH3 domains and function as substrates for p59Fyn in resting T cells (1â€"3). SKAP55 contains an amino-terminal pleckstrin homology domain and a carboxy-terminal SH3 domain binding motif of adjacent arginine and lysine residues followed by tandem tyrosines (i.e. RKxxYxxY) (4,5). SKAP55-R, similar in overall structure to SKAP55, contains a coiled-coil N-terminal domain (1,2). SKAP55 associates with SLAP-130, another component of the Fyn complex, which plays a role in the regulation of signaling events initiated by lymphocyte antigen receptors leading up to T cell activation (6). The human Fyb gene maps to chromosome 5p13.1 and encodes a 783 amino acid protein (7).
Synonyms: ADAP, Adhesion and degranulation promoting adaptor protein, FYB 120/130, Fyb, FYB-120/130, FYB_HUMAN, FYN binding protein, FYN T binding protein, FYN-binding protein, FYN-T-binding protein, p120/p130, PRO0823, SLAP 130, SLAP-130, SLAP130, SLP 76 associated phosphoprotein, SLP-76-associated phosphoprotein, SLP76 associated phosphoprotein.
|Pathways||TCR Signaling, Protein targeting to Nucleus|
Application DetailsProduct Details anti-FYB Antibody Target Details FYB Handling Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-FYB Antibody Target Details FYB Application Details Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.|
|Precaution of Use||This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.|
|Storage Comment||Store at 4°C|
|Expiry Date||12 months|