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|Antigen||Receptor-Interacting Serine-threonine Kinase 2 (RIPK2) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This RIPK2 antibody is un-conjugated Alternatives|
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
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Product Details anti-RIPK2 AntibodyTarget Details RIPK2 Application Details Handling Images
|Specificity||This antibody recognises Human RIP2 (Receptor-interacting kinase 2), a 61.2 kDa cytoplasmic protein belonging to the protein kinase superfamily.|
|Immunogen||A peptide corresponding to amino acids near the amino terminus of human RIP2.|
Target Details RIPK2Product Details anti-RIPK2 Antibody Application Details Handling Images back to top
|Alternative Name||RIPK2 (RIPK2 Antibody Abstract)|
|Background||RIP2, known also as RICK and CARDIAK, is a novel kinase that regulates TNF and Fas induced-apoptosis and is involved in the generation of the pro-inflammatory cytokine IL-1beta. Over expression of RIP2 has been shown to induce apoptosis, and the activation of NF-Kappa-B and JNK. RIP2 is widely expressed in a range of human tissues.Synonyms: CARD-containing IL-1 beta ICE-kinase, CARDIAK, RICK, RIP-2, RIP-like-interacting CLARP kinase, RIP2, Receptor-interacting protein 2, Receptor-interacting serine/threonine-protein kinase 2|
|Pathways||TCR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades|
Application DetailsProduct Details anti-RIPK2 Antibody Target Details RIPK2 Handling Images back to top
Immunohistochemistry on frozen sections: 10g/mL. Western Blot: 0.5 - 1.0g/mL, detects a band of approximately 60 kDa in A431 cell lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-RIPK2 Antibody Target Details RIPK2 Application Details Images back to top
|Buffer||Phosphate buffered saline containing 0.02 % Sodium Azide (NaN3)|
|Precaution of Use||This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.|
ImagesProduct Details anti-RIPK2 Antibody Target Details RIPK2 Application Details Handling back to top