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DNA Damage Repair

DNA is the carrier of the genetic information that defines any living being. The genetic code fixed in DNA is crucial for processes on a subcellular scale up to the appearance and function of the organism as s whole. Nonetheless, DNA is constantly exposed to insults from endogenous sources such as hydrolysis, oxidation, alkylation, or replication errors. In addition, ionizing radiation, UV radiation, and a plethora of chemical reagents are external factors that threaten the integrity of DNA.

Unlike RNA and proteins, DNA is not being degraded and re-synthesized upon damage. Instead, various repair pathways are in existence to assure that the DNA remains intact. Francis Crick noted in 1974 that “we totally missed the possible role of enzymes in [DNA] repair. I later came to realize that DNA is so precious that probably many distinct mechanisms could exist.”

This presage holds true today: over a hundred genes have been characterized since that are involved in an intricate network of DNA repair pathways. DNA damage can be repaired via six different pathways depending on the nature of the lesion: chemical modifications, misincorporated nucleotides, and cross-links are reverted through direct reversal (DR), mismatch repair (MMR), and nucleotide excision repair mechanisms. DNA single strand breaks are being mended via base excision repair. Highly mutagenic DNA double strand breaks finally are repaired through a number of complex pathways that rely on homologous recombination (HR) with the sister chromatid (in the S or G2 phase of the cell cycle) or non-homologous end-joining (NHEJ) of both ends of the double strand break. In case a DNA lesion cannot be repaired in time, specialized DNA polymerases enable trans-lesion synthesis (TLS) in order to prevent the DNA replication fork from stalling. Mutations that render components of these repair pathways non-functional lead to diseases such as xeroderma pigmentosum, ataxia telangiectasia, Fanconi anemia, and a predisposition for cancer.

Besides, these repair mechanisms are of high interest for current targeted genome editing approaches that typically take advantage of the cellular DNA repair machinery.

Canonical Non-Homologous End-Joining

PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide):

This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010].   More...

XRCC6 - X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6

The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions...

XRCC5 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining)):

The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or...
Antigens in this category:
ATM (Ataxia Telangiectasia Mutated): ATM antibodies ATM ELISA Kits ATM Proteins
TRIM29 (Tripartite Motif Containing 29): TRIM29 antibodies TRIM29 ELISA Kits TRIM29 Proteins
ATR (Ataxia Telangiectasia and Rad3 Related): ATR antibodies ATR ELISA Kits  
H2AFX - H2A Histone Family, Member X: H2AFX antibodies H2AFX ELISA Kits H2AFX Proteins
XRCC4 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4): XRCC4 antibodies XRCC4 ELISA Kits XRCC4 Proteins
LIG4 - Ligase IV, DNA, ATP-Dependent: LIG4 antibodies LIG4 ELISA Kits LIG4 Proteins
NHEJ1 - Nonhomologous End-Joining Factor 1: NHEJ1 antibodies NHEJ1 ELISA Kits NHEJ1 Proteins
APTX - Aprataxin: APTX antibodies APTX ELISA Kits APTX Proteins
APLF (Aprataxin and PNKP Like Factor): APLF antibodies APLF ELISA Kits APLF Proteins
DCLRE1C (DNA Cross-Link Repair 1C): DCLRE1C antibodies DCLRE1C ELISA Kits DCLRE1C Proteins
PNKP (Polynucleotide Kinase 3'-Phosphatase): PNKP antibodies PNKP ELISA Kits PNKP Proteins
DNTT - Deoxynucleotidyltransferase, terminal: DNTT antibodies DNTT ELISA Kits DNTT Proteins
POLL (Polymerase (DNA Directed), lambda): POLL antibodies POLL ELISA Kits POLL Proteins
POLM - Polymerase (DNA Directed), mu: POLM antibodies   POLM Proteins
MRE11A - MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae): MRE11A antibodies MRE11A ELISA Kits MRE11A Proteins
RAD50 (RAD50 Homolog (S. Cerevisiae)): RAD50 antibodies RAD50 ELISA Kits RAD50 Proteins
NBN - Nibrin: NBN antibodies NBN ELISA Kits NBN Proteins
TP53BP1 (Tumor Protein P53 Binding Protein 1): TP53BP1 antibodies TP53BP1 ELISA Kits TP53BP1 Proteins

Microhomology-Mediated End-Joining

PARP1 (Poly (ADP-Ribose) Polymerase 1):

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery...   More...
Antigens in this category:
LIG3 (Ligase III, DNA, ATP-Dependent): LIG3 antibodies LIG3 ELISA Kits LIG3 Proteins
LIG2 - Ligase II, DNA, ATP-Dependent:   LIG2 ELISA Kits  
PARP2 - Poly [ADP-Ribose] Polymerase 2:      
PARP2 - Poly (ADP-Ribose) Polymerase 2: PARP2 antibodies PARP2 ELISA Kits PARP2 Proteins
LIG1 (Ligase I, DNA, ATP-Dependent): LIG1 antibodies LIG1 ELISA Kits LIG1 Proteins
ATM (Ataxia Telangiectasia Mutated): ATM antibodies ATM ELISA Kits ATM Proteins
TRIM29 (Tripartite Motif Containing 29): TRIM29 antibodies TRIM29 ELISA Kits TRIM29 Proteins
ATR (Ataxia Telangiectasia and Rad3 Related): ATR antibodies ATR ELISA Kits  
RBBP8 - Retinoblastoma Binding Protein 8: RBBP8 antibodies RBBP8 ELISA Kits RBBP8 Proteins
MRE11A - MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae): MRE11A antibodies MRE11A ELISA Kits MRE11A Proteins
RAD50 (RAD50 Homolog (S. Cerevisiae)): RAD50 antibodies RAD50 ELISA Kits RAD50 Proteins
NBN - Nibrin: NBN antibodies NBN ELISA Kits NBN Proteins
RECQL2 - RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding: RECQL2 antibodies RECQL2 ELISA Kits  

Homologous Recombination

RAD51 (DNA Repair Protein Homolog 1):

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of...   More...

BRCA1 (Breast Cancer 1):

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded...

BRCA2 (Breast Cancer 2, Early Onset):

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are...
Antigens in this category:
POLE (Polymerase (DNA Directed), Epsilon, Catalytic Subunit): POLE antibodies    
POLE2 - Polymerase (DNA Directed), epsilon 2 (p59 Subunit): POLE2 antibodies POLE2 ELISA Kits POLE2 Proteins
POLE3 - Polymerase (DNA Directed), epsilon 3 (p17 Subunit): POLE3 antibodies POLE3 ELISA Kits POLE3 Proteins
POLE4 (Polymerase (DNA-Directed), epsilon 4 (p12 Subunit)): POLE4 antibodies POLE4 ELISA Kits POLE4 Proteins
POLD1 - Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa: POLD1 antibodies POLD1 ELISA Kits POLD1 Proteins
POLD2 (Polymerase (DNA Directed), delta 2, Accessory Subunit): POLD2 antibodies POLD2 ELISA Kits POLD2 Proteins
POLD3 - Polymerase (DNA-Directed), delta 3, Accessory Subunit: POLD3 antibodies POLD3 ELISA Kits POLD3 Proteins
POLD4 (Polymerase (DNA-Directed), delta 4, Accessory Subunit): POLD4 antibodies POLD4 ELISA Kits POLD4 Proteins
ATM (Ataxia Telangiectasia Mutated): ATM antibodies ATM ELISA Kits ATM Proteins
TRIM29 (Tripartite Motif Containing 29): TRIM29 antibodies TRIM29 ELISA Kits TRIM29 Proteins
ATR (Ataxia Telangiectasia and Rad3 Related): ATR antibodies ATR ELISA Kits  
Rad51B - RAD51 Homolog B (S. Cerevisiae): Rad51B antibodies   Rad51B Proteins
RAD51C (RAD51 Homolog C (S. Cerevisiae)): RAD51C antibodies RAD51C ELISA Kits RAD51C Proteins
RAD51D - RAD51 Homolog D (S. Cerevisiae): RAD51D antibodies RAD51D ELISA Kits RAD51D Proteins
XRCC1 - XRCC2: XRCC1 antibodies XRCC1 ELISA Kits XRCC1 Proteins
XRCC3 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3): XRCC3 antibodies XRCC3 ELISA Kits XRCC3 Proteins
BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1): BRIP1 antibodies BRIP1 ELISA Kits  
BARD1 (BRCA1 Associated RING Domain 1): BARD1 antibodies BARD1 ELISA Kits BARD1 Proteins
RBBP8 - Retinoblastoma Binding Protein 8: RBBP8 antibodies RBBP8 ELISA Kits RBBP8 Proteins
FAM175A - Family with Sequence Similarity 175, Member A: FAM175A antibodies FAM175A ELISA Kits FAM175A Proteins
UIMC1 - Ubiquitin Interaction Motif Containing 1: UIMC1 antibodies UIMC1 ELISA Kits UIMC1 Proteins
MRE11A - MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae): MRE11A antibodies MRE11A ELISA Kits MRE11A Proteins
RAD50 - RAD50:      
RAD50 (RAD50 Homolog (S. Cerevisiae)): RAD50 antibodies RAD50 ELISA Kits RAD50 Proteins
NBN - Nibrin: NBN antibodies NBN ELISA Kits NBN Proteins
TP53BP1 (Tumor Protein P53 Binding Protein 1): TP53BP1 antibodies TP53BP1 ELISA Kits TP53BP1 Proteins
RPA1 - replication protein A1, 70kDa:      
RPA1 - Replication Protein A1, 70kDa: RPA1 antibodies RPA1 ELISA Kits RPA1 Proteins
RPA2 (Replication Protein A2, 32kDa): RPA2 antibodies RPA2 ELISA Kits RPA2 Proteins
RPA3 (Replication Protein A3, 14kDa): RPA3 antibodies   RPA3 Proteins
PALB2 (Partner and Localizer of BRCA2): PALB2 antibodies PALB2 ELISA Kits PALB2 Proteins
TOP3A (Topoisomerase (DNA) III alpha): TOP3A antibodies TOP3A ELISA Kits  
RMI1 (Homolog of Yeast RecQ-mediated Genome Instability 1): RMI1 antibodies RMI1 ELISA Kits RMI1 Proteins
RMI2 (RMI2, RecQ Mediated Genome Instability 2, Homolog (S. Cerevisiae)): RMI2 antibodies RMI2 ELISA Kits RMI2 Proteins
DNA2 (DNA Replication Helicase 2 Homolog (Yeast)): DNA2 antibodies DNA2 ELISA Kits  
RECQL2 - RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding: RECQL2 antibodies RECQL2 ELISA Kits  
RAD54L (RAD54-Like (S. Cerevisiae)): RAD54L antibodies RAD54L ELISA Kits RAD54L Proteins
MUS81 (MUS81 Endonuclease Homolog (S. Cerevisiae)): MUS81 antibodies MUS81 ELISA Kits MUS81 Proteins
EME1 - Essential Meiotic Endonuclease 1 Homolog 1 (S. Pombe): EME1 antibodies EME1 ELISA Kits EME1 Proteins
SLX1B - SLX1 Structure-Specific Endonuclease Subunit Homolog B (S. Cerevisiae): SLX1B antibodies SLX1B ELISA Kits SLX1B Proteins
BTBD12 - BTB (POZ) Domain Containing 12: BTBD12 antibodies BTBD12 ELISA Kits  
GEN1 (Gen Endonuclease Homolog 1 (Drosophila)): GEN1 antibodies    

Single Strand Annealing

MSH2 - MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli)

This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E....

ERCC1 (Excision Repair Cross Complementing Polypeptide-1):

The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced...
Antigens in this category:
MSH3 (MutS Homolog 3 (E. Coli)): MSH3 antibodies MSH3 ELISA Kits  
ERCC4 - Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 4: ERCC4 antibodies ERCC4 ELISA Kits  
ATM (Ataxia Telangiectasia Mutated): ATM antibodies ATM ELISA Kits ATM Proteins
TRIM29 (Tripartite Motif Containing 29): TRIM29 antibodies TRIM29 ELISA Kits TRIM29 Proteins
ATR (Ataxia Telangiectasia and Rad3 Related): ATR antibodies ATR ELISA Kits  
MRE11A - MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae): MRE11A antibodies MRE11A ELISA Kits MRE11A Proteins
RAD50 (RAD50 Homolog (S. Cerevisiae)): RAD50 antibodies RAD50 ELISA Kits RAD50 Proteins
NBN - Nibrin: NBN antibodies NBN ELISA Kits NBN Proteins
RPA1 - Replication Protein A1, 70kDa: RPA1 antibodies RPA1 ELISA Kits RPA1 Proteins
RPA2 (Replication Protein A2, 32kDa): RPA2 antibodies RPA2 ELISA Kits RPA2 Proteins
RPA3 (Replication Protein A3, 14kDa): RPA3 antibodies   RPA3 Proteins
RAD52 (RAD52 Homolog (S. Cerevisiae)): RAD52 antibodies RAD52 ELISA Kits RAD52 Proteins

Break-Induced Replication

MCM2 - Minichromosome Maintenance Complex Component 2

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of...

MCM7 - Minichromosome Maintenance Complex Component 7

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of...
Antigens in this category:
RAD51 (DNA Repair Protein Homolog 1): RAD51 antibodies RAD51 ELISA Kits RAD51 Proteins
MRE11A - MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae): MRE11A antibodies MRE11A ELISA Kits MRE11A Proteins
RAD50 (RAD50 Homolog (S. Cerevisiae)): RAD50 antibodies RAD50 ELISA Kits RAD50 Proteins
NBN - Nibrin: NBN antibodies NBN ELISA Kits NBN Proteins
RPA1 - Replication Protein A1, 70kDa: RPA1 antibodies RPA1 ELISA Kits RPA1 Proteins
RPA2 (Replication Protein A2, 32kDa): RPA2 antibodies RPA2 ELISA Kits RPA2 Proteins
RPA3 (Replication Protein A3, 14kDa): RPA3 antibodies   RPA3 Proteins
MCM3 (Minichromosome Maintenance Complex Component 3): MCM3 antibodies MCM3 ELISA Kits MCM3 Proteins
MCM4 (Minichromosome Maintenance Deficient 4): MCM4 antibodies MCM4 ELISA Kits MCM4 Proteins
MCM5 - Minichromosome Maintenance Complex Component 5: MCM5 antibodies MCM5 ELISA Kits MCM5 Proteins
MCM6 - Minichromosome Maintenance Complex Component 6: MCM6 antibodies MCM6 ELISA Kits MCM6 Proteins

Base Excision Repair

OGG1 (8-Oxoguanine DNA Glycosylase):

This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the...   More...

UNG (Uracil-DNA Glycosylase):

This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by...

APEX1 - APEX Nuclease (Multifunctional DNA Repair Enzyme) 1

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that...
Antigens in this category:
MPG - N-Methylpurine-DNA Glycosylase: MPG antibodies MPG ELISA Kits MPG Proteins
SMUG1 - Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1: SMUG1 antibodies SMUG1 ELISA Kits SMUG1 Proteins
TDG - Thymine-DNA Glycosylase: TDG antibodies TDG ELISA Kits TDG Proteins
MBD4 (Methyl-CpG Binding Domain Protein 4): MBD4 antibodies MBD4 ELISA Kits MBD4 Proteins
MUTYH - MutY Homolog (E. Coli): MUTYH antibodies MUTYH ELISA Kits MUTYH Proteins
NTHL1 - NTH1: NTHL1 antibodies NTHL1 ELISA Kits  
NEIL1 (Endonuclease VIII-Like 1): NEIL1 antibodies NEIL1 ELISA Kits NEIL1 Proteins
NEIL2 (Nei Endonuclease VIII-Like 2 (E. Coli)): NEIL2 antibodies NEIL2 ELISA Kits NEIL2 Proteins
NEIL3 (Nei Endonuclease VIII-Like 3 (E. Coli)): NEIL3 antibodies NEIL3 ELISA Kits NEIL3 Proteins
POLB (Polymerase (DNA Directed), beta): POLB antibodies POLB ELISA Kits POLB Proteins
POLD1 - Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa: POLD1 antibodies POLD1 ELISA Kits POLD1 Proteins
POLD2 (Polymerase (DNA Directed), delta 2, Accessory Subunit): POLD2 antibodies POLD2 ELISA Kits POLD2 Proteins
POLD3 - Polymerase (DNA-Directed), delta 3, Accessory Subunit: POLD3 antibodies POLD3 ELISA Kits POLD3 Proteins
POLD4 (Polymerase (DNA-Directed), delta 4, Accessory Subunit): POLD4 antibodies POLD4 ELISA Kits POLD4 Proteins
FEN1 (Flap Structure-Specific Endonuclease 1): FEN1 antibodies FEN1 ELISA Kits FEN1 Proteins
LIG1 (Ligase I, DNA, ATP-Dependent): LIG1 antibodies LIG1 ELISA Kits LIG1 Proteins

Nuleotide Excision Repair

POLR2B - Polymerase (RNA) II (DNA Directed) Polypeptide B, 140kDa

This gene encodes the second largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with at least two other polymerase subunits, forms a structure within the polymerase that maintains contact in the active site of the enzyme between the DNA template and the newly synthesized RNA. [provided by RefSeq, Jul 2008].   More...

XPC (Xeroderma Pigmentosum, Complementation Group C):

This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including...

DDB1 (Damage-Specific DNA Binding Protein 1, 127kDa):

The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48)...
Antigens in this category:
XPA (Xeroderma Pigmentosum, Complementation Group A): XPA antibodies XPA ELISA Kits XPA Proteins
RAD23A (RAD23 Homolog A (S. Cerevisiae)): RAD23A antibodies RAD23A ELISA Kits RAD23A Proteins
RAD23B - RAD23 Homolog B (S. Cerevisiae): RAD23B antibodies RAD23B ELISA Kits RAD23B Proteins
CETN2 (Centrin, EF-Hand Protein, 2): CETN2 antibodies CETN2 ELISA Kits CETN2 Proteins
DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa): DDB2 antibodies DDB2 ELISA Kits DDB2 Proteins
ERCC1 (Excision Repair Cross Complementing Polypeptide-1): ERCC1 antibodies ERCC1 ELISA Kits ERCC1 Proteins
ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2): ERCC2 antibodies ERCC2 ELISA Kits ERCC2 Proteins
ERCC3 - DNA Repair Protein Complementing XP-B Cells: ERCC3 antibodies ERCC3 ELISA Kits ERCC3 Proteins
XP-B - Xeroderma Pigmentosum, Complementation Group B:   XP-B ELISA Kits  
GTF2H1 - General Transcription Factor IIH, Polypeptide 1, 62kDa: GTF2H1 antibodies GTF2H1 ELISA Kits GTF2H1 Proteins
GTF2H4 (General Transcription Factor IIH, Polypeptide 4, 52kDa): GTF2H4 antibodies   GTF2H4 Proteins
GTF2H3 (General Transcription Factor IIH, Polypeptide 3, 34kD): GTF2H3 antibodies GTF2H3 ELISA Kits GTF2H3 Proteins
GTF2H5 - General Transcription Factor IIH, Polypeptide 5: GTF2H5 antibodies GTF2H5 ELISA Kits GTF2H5 Proteins
CDK7 (Cyclin-Dependent Kinase 7): CDK7 antibodies CDK7 ELISA Kits CDK7 Proteins
RFC1 - Replication Factor C (Activator 1) 1, 145kDa: RFC1 antibodies RFC1 ELISA Kits RFC1 Proteins
RFC2 (Replication Factor C (Activator 1) 2, 40kDa): RFC2 antibodies RFC2 ELISA Kits RFC2 Proteins
RFC3 - Replication Factor C (Activator 1) 3, 38kDa: RFC3 antibodies RFC3 ELISA Kits RFC3 Proteins
RFC4 (Replication Factor C (Activator 1) 4, 37kDa): RFC4 antibodies RFC4 ELISA Kits RFC4 Proteins
RFC5 (Replication Factor C (Activator 1) 5, 36.5kDa): RFC5 antibodies RFC5 ELISA Kits RFC5 Proteins
POLK - Polymerase (DNA Directed) kappa: POLK antibodies POLK ELISA Kits POLK Proteins
ERCC4 - Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 4: ERCC4 antibodies ERCC4 ELISA Kits  
ERCC5 - DNA Repair Protein Complementing XP-G Cells: ERCC5 antibodies ERCC5 ELISA Kits ERCC5 Proteins
ERCC6 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6): ERCC6 antibodies   ERCC6 Proteins
ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8): ERCC8 antibodies ERCC8 ELISA Kits ERCC8 Proteins
POLE (Polymerase (DNA Directed), Epsilon, Catalytic Subunit): POLE antibodies    
POLE2 - Polymerase (DNA Directed), epsilon 2 (p59 Subunit): POLE2 antibodies POLE2 ELISA Kits POLE2 Proteins
POLE3 - Polymerase (DNA Directed), epsilon 3 (p17 Subunit): POLE3 antibodies POLE3 ELISA Kits POLE3 Proteins
POLE4 (Polymerase (DNA-Directed), epsilon 4 (p12 Subunit)): POLE4 antibodies POLE4 ELISA Kits POLE4 Proteins
PCNA (Proliferating Cell Nuclear Antigen): PCNA antibodies PCNA ELISA Kits PCNA Proteins
XRCC1 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1): XRCC1 antibodies XRCC1 ELISA Kits XRCC1 Proteins
FEN1 (Flap Structure-Specific Endonuclease 1): FEN1 antibodies FEN1 ELISA Kits FEN1 Proteins
LIG1 (Ligase I, DNA, ATP-Dependent): LIG1 antibodies LIG1 ELISA Kits LIG1 Proteins
RPA1 - Replication Protein A1, 70kDa: RPA1 antibodies RPA1 ELISA Kits RPA1 Proteins
RPA2 (Replication Protein A2, 32kDa): RPA2 antibodies RPA2 ELISA Kits RPA2 Proteins
RPA3 (Replication Protein A3, 14kDa): RPA3 antibodies   RPA3 Proteins

Mismatch Repair

MSH2 - MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli)

This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].   More...

MSH3 (MutS Homolog 3 (E. Coli)):

The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS...

MSH6 (MutS Homolog 6 (E. Coli)):

This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to...
Antigens in this category:
MLH1 (MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli)): MLH1 antibodies MLH1 ELISA Kits MLH1 Proteins
PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae)): PMS2 antibodies PMS2 ELISA Kits PMS2 Proteins
RFC1 - Replication Factor C (Activator 1) 1, 145kDa: RFC1 antibodies RFC1 ELISA Kits RFC1 Proteins
RFC2 (Replication Factor C (Activator 1) 2, 40kDa): RFC2 antibodies RFC2 ELISA Kits RFC2 Proteins
RFC3 - Replication Factor C (Activator 1) 3, 38kDa: RFC3 antibodies RFC3 ELISA Kits RFC3 Proteins
RFC4 (Replication Factor C (Activator 1) 4, 37kDa): RFC4 antibodies RFC4 ELISA Kits RFC4 Proteins
RFC5 (Replication Factor C (Activator 1) 5, 36.5kDa): RFC5 antibodies RFC5 ELISA Kits RFC5 Proteins
POLD1 - Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa: POLD1 antibodies POLD1 ELISA Kits POLD1 Proteins
POLD2 (Polymerase (DNA Directed), delta 2, Accessory Subunit): POLD2 antibodies POLD2 ELISA Kits POLD2 Proteins
POLD3 - Polymerase (DNA-Directed), delta 3, Accessory Subunit: POLD3 antibodies POLD3 ELISA Kits POLD3 Proteins
PCNA (Proliferating Cell Nuclear Antigen): PCNA antibodies PCNA ELISA Kits PCNA Proteins
LIG1 (Ligase I, DNA, ATP-Dependent): LIG1 antibodies LIG1 ELISA Kits LIG1 Proteins
RPA1 - Replication Protein A1, 70kDa: RPA1 antibodies RPA1 ELISA Kits RPA1 Proteins
RPA2 (Replication Protein A2, 32kDa): RPA2 antibodies RPA2 ELISA Kits RPA2 Proteins
RPA3 (Replication Protein A3, 14kDa): RPA3 antibodies   RPA3 Proteins
EXO1 - Exonuclease 1: EXO1 antibodies EXO1 ELISA Kits EXO1 Proteins

Direct Reversal

MGMT (O6-Methylguanine-DNA-Methyltransferase):

Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a   More...

ALKBH - AlkB, Alkylation Repair Homolog 1 (E. Coli)

This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation...

ALKBH2 - AlkB, Alkylation Repair Homolog 2

The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in...
Antigens in this category:
ALKBH3 - AlkB, Alkylation Repair Homolog 3 (E. Coli): ALKBH3 antibodies ALKBH3 ELISA Kits ALKBH3 Proteins

Trans-Lesion Synthesis

POLI - Polymerase (DNA Directed) iota

Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity...

POLH - Polymerase (DNA Directed), eta

This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed...
Antigens in this category:
REV3L (REV3-Like, Polymerase (DNA Directed), Zeta, Catalytic Subunit): REV3L antibodies    
REV1 (REV1, Polymerase (DNA Directed)): REV1 antibodies REV1 ELISA Kits REV1 Proteins
POLK - Polymerase (DNA Directed) kappa: POLK antibodies POLK ELISA Kits POLK Proteins
PCNA (Proliferating Cell Nuclear Antigen): PCNA antibodies PCNA ELISA Kits PCNA Proteins