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anti-Human Integrin beta 2 Antibodies:
anti-Mouse (Murine) Integrin beta 2 Antibodies:
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Mouse (Murine) Monoclonal Integrin beta 2 Primary Antibody for FACS, Func - ABIN457404
Abraham, Miller: Molecular mechanisms of IL-2 gene regulation following costimulation through LFA-1. in Journal of immunology (Baltimore, Md. : 1950) 2001
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Mouse (Murine) Monoclonal Integrin beta 2 Primary Antibody for FACS, Func - ABIN457348
Avni, Pur, Yefenof, Baniyash: Complement receptor 3 of macrophages is associated with galectin-1-like protein. in Journal of immunology (Baltimore, Md. : 1950) 1998
Show all 9 Pubmed References
Mouse (Murine) Monoclonal Integrin beta 2 Primary Antibody for FACS, Func - ABIN457430
Sakurai, Taguchi, Anand, Ambati, Gragoudas, Miller, Adamis, Ambati: Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization. in Investigative ophthalmology & visual science 2003
Show all 8 Pubmed References
Mouse (Murine) Monoclonal Integrin beta 2 Primary Antibody for BR, IHC (f) - ABIN2689033
Driessens, van Hulten, Zuurbier, La Rivière, Roos: Inhibition and stimulation of LFA-1 and Mac-1 functions by antibodies against murine CD18. Evidence that the LFA-1 binding sites for ICAM-1, -2, and -3 are distinct. in Journal of leukocyte biology 1997
Show all 7 Pubmed References
Mouse (Murine) Monoclonal Integrin beta 2 Primary Antibody for BR, Func - ABIN1176975
Isobe, Yagita, Okumura, Ihara: Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1. in Science (New York, N.Y.) 1992
Show all 6 Pubmed References
Human Monoclonal Integrin beta 2 Primary Antibody for WB - ABIN1882257
Chen, Xie, Nishida, Li, Walz, Springer: Requirement of open headpiece conformation for activation of leukocyte integrin alphaXbeta2. in Proceedings of the National Academy of Sciences of the United States of America 2010
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Human Monoclonal Integrin beta 2 Primary Antibody for FACS, Func - ABIN192094
Cera, Fabbri, Molendini, Corada, Orsenigo, Rehberg, Reichel, Krombach, Pardi, Dejana: JAM-A promotes neutrophil chemotaxis by controlling integrin internalization and recycling. in Journal of cell science 2009
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Human Monoclonal Integrin beta 2 Primary Antibody for FACS, Func - ABIN94005
Nakayama, Yoshizaki, Prinetti, Sonnino, Mauri, Takamori, Ogawa, Iwabuchi: Lyn-coupled LacCer-enriched lipid rafts are required for CD11b/CD18-mediated neutrophil phagocytosis of nonopsonized microorganisms. in Journal of leukocyte biology 2008
Show all 19 Pubmed References
Human Monoclonal Integrin beta 2 Primary Antibody for FACS, Func - ABIN94007
Sewald, Gebert-Vogl, Prassl, Barwig, Weiss, Fabbri, Osicka, Schiemann, Busch, Semmrich, Holzmann, Sebo, Haas: Integrin subunit CD18 Is the T-lymphocyte receptor for the Helicobacter pylori vacuolating cytotoxin. in Cell host & microbe 2008
Show all 20 Pubmed References
Human Monoclonal Integrin beta 2 Primary Antibody for FACS, Func - ABIN94008
Morova, Osicka, Masin, Sebo: RTX cytotoxins recognize beta2 integrin receptors through N-linked oligosaccharides. in Proceedings of the National Academy of Sciences of the United States of America 2008
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CD18 deficiency curbs methionine-choline-deficient-mediated liver injury by limiting the activation of innate immune cells in the liver without compromising intrahepatic cytokine activation
results identify a role for Caveolin (Cav (show CA5A Antibodies))1in membrane organization and beta2 integrin Lfa1 (show ITGAL Antibodies) function in primary CD8 (show CD8A Antibodies) T cells.
Coro1A (show CORO1A Antibodies) represents an important novel player in integrin biology, with key functions in polymorphonuclear neutrophils trafficking during innate immunity.
EAE induced by weak activation of innate immunity requires the NLRP3 inflamma (show CXCR4 Antibodies)some and (show CXCR2 Antibodies)is sensitive to interferon-beta treatment
These results identify CD47 (show CD47 Antibodies) as an important regulator of LFA-1 (show ITGAL Antibodies) and VLA-4 integrin-adhesive functions in T cell proliferation.
lymphatic vessel expansion occurs in two distinct phases; the first wave of expansion is dependent on IL-7 (show IL7 Antibodies); the second phase, responsible for leukocyte exit from the glands, is regulated by lymphotoxin (show LTB Antibodies) (LT)betaR signaling
both GDF-15 (show GDF15 Antibodies) and TGF-beta1 (show TGFB1 Antibodies) counteract chemokine (show CCL1 Antibodies)-induced integrin activation on neutrophils via the ALK-5 (show TGFBR1 Antibodies)/TGF-betaRII heterodimer.
the Slam (show SLAMF1 Antibodies) locus has an overall inhibitory role during NK cell activation that is solely dependent on 2B4 (show CD244 Antibodies). This effect is influenced by cytokines and leads to suppression of LFA-1 (show ITGAL Antibodies) activity.
Wild-type C57BL/6 mice with pristane-induced lupus developed a strong IFN signature, which was absent in immunoglobulin-deficient (muMT), C3(-/-) , and CD18(-/-) mice.
Study suggest an important impact of NKT (show CTSL1 Antibodies) cells and postulate a critical function for LFA-1 (show ITGAL Antibodies) during processes of liver regeneration.
findings suggest the partitioning in soluble CD18 to reflect a compensatory anti-inflammatory response syndrome and hyperinflammation, respectively, manifested as part of sepsis.
activation of LFA-1 (show ITGAL Antibodies) (alphaLbeta2) and Mac-1 (show ITGAM Antibodies) (alphaMbeta2), two subfamilies of integrin beta2 complexes, on human primary monocytes following platelet releasate treatment
membrane-bound lymphotoxin-beta receptor (LTbetaR) and CXC chemokine receptor (show CXCR4 Antibodies) 2 (CXCR2 (show CXCR2 Antibodies)), is involved in type B EAE development
data suggest that regulation of LFA-1 (show ITGAL Antibodies) is one reason for the different activity of NK cells during differentiation
The single nucleotide polymorphism rs1143678 substitutes Pro(1146) for Ser (show SIGLEC1 Antibodies) in the integrin alphaM cytoplasmic tail generates a noncanonical 14-3-3zeta (show YWHAZ Antibodies) binding site that modulates integrin alphaM(PS)beta2 outside-in signaling
this study shows that cross-talk between LFA-1 (show ITGAL Antibodies) and Notch1 (show NOTCH1 Antibodies) through the Akt (show AKT1 Antibodies)/ERK (show EPHB2 Antibodies)-GSK3beta (show GSK3b Antibodies) signaling enhances T cell differentiation toward Th1 (show TH1L Antibodies)
FRbeta (show FOLR2 Antibodies) as a novel CD11b/CD18 (show ITGAM Antibodies) regulator for trafficking and homing of a subset of macrophages on collagen.
The results show that with LFA-1 (show ITGAL Antibodies) antibodies, we can activate LFA-1 (show ITGAL Antibodies) and inhibit alpha4beta1, inhibit both LFA-1 (show ITGAL Antibodies) and alpha4beta1, inhibit LFA-1 (show ITGAL Antibodies) but not alpha4beta1, or not affect LFA-1 (show ITGAL Antibodies) or alpha4beta1
K152 and D120 within the PH domain of SKAP55 (show SKAP1 Antibodies) regulate plasma membrane targeting and T cell receptor-mediated activation of LFA-1 (show ITGAL Antibodies).
LIGHT and LTBR (show LTBR Antibodies) interaction increases the survival and proliferation of human bone marrow-derived mesenchymal stem cells, and therefore, LIGHT might play an important role in stem cell therapy.
Identification of numerous variations in exonic and intronic regions within the ITGB2 gene in Bos taurus and indicus screened for bovine leukocyte adhesion deficiency.
intramammarily administered lipopolysaccharides seem to play an important role in modulating L-selectin (show SELL Antibodies) and beta2 integrin expression on circulating bovine polymorphonuclear leukocytes
A delay in apoptosis was demonstrated in CD18-deficient bovine neutrophils and this appeared to be closely associated with lowered signalling via [Ca2 (show CA2 Antibodies)+]i, diminished annexin V (show ANXA5 Antibodies) expression on the cell surface, and decreased caspase 3 (show CASP3 Antibodies) activity in lysates
The I-EGF (show EGF Antibodies)-3 domain of bovine CD18 (amino acid residues 541-581) is critical for conferring species-specific susceptibility to Mannheimia haemolytica leukotoxin.
These results clearly indicate that the bovine CD18 subunit of beta(2)-integrins is the functional receptor for M. haemolytica Lkt.[ruminant-specific leukotoxin]
study provides evidence that the expression of CD18 was downregulated by the plasma glycoforms of alpha-1 acid glycoprotein (show ORM1 Antibodies) and inhibited the chemotaxis of monocytes
Loss of CD18 is associated with bovine leukocyte adhesion deficiency.
Intact signal peptide of CD18, the beta-subunit (show POLG Antibodies) of beta2-integrins, renders ruminants susceptible to Mannheimia haemolytica leukotoxin.
CR3 (show ITGAM Antibodies) plays a cardinal (show CARD8 Antibodies) role in beta-glucan signalling in porcine neutrophils, while macrophages use a more diverse receptor array to detect and respond towards beta-glucans.
The expression of zona pellucida glycoprotein 3 (show ZP3 Antibodies) and integrin beta-2 in oocytes after brilliant cresyl blue staining is reported.
early CD18 downregulation is profitable for the host in a situation with an intense LPS (show IRF6 Antibodies) stimulus
It is concluded that porcine CD18 is necessary to mediate A. pleuropneumoniae ApxIIIA toxin-induced leukolysis.
Integrin CD11c (show ITGAX Antibodies)/CD18 alpha-chain (show FCGRT Antibodies) phosphorylation is functionally important.
The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.
cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor)
, cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
, complement receptor C3 beta-subunit
, complement receptor C3 subunit beta
, integrin beta chain, beta 2
, integrin beta-2
, leukocyte cell adhesion molecule CD18
, leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
, Mac-1 beta
, lymphocyte function associated antigen 1
, macrophage antigen-1 beta
, CD18 subunit
, Leu-CAM receptor
, integrin, beta 2 (antigen CD18 subunit (p95), lymphocyte function-associated antigen 1, integrin B2)
, integrin beta 2 subunit
, CD18 leukocyte adhesion molecule
, antigen CD18
, integrin beta-2 chain
, integrin beta 2
, integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1
, integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit)
, macrophage antigen 1 (mac-1) beta subunit)
, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
, Complement receptor C3 subunit beta
, Integrin beta-2
, integrin beta-2 subunit
, integrin subunit beta 2 S homeolog
, integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)