|Application / Reactivity||Mouse (Murine)|
|Blocking Reagent (BR)||1 Antibodies|
|Enzyme Immunoassay (EIA)||1 Antibodies|
|Flow Cytometry (FACS)||28 Antibodies|
|Functional Studies (Func)||8 Antibodies|
|Immunocytochemistry (ICC)||1 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||9 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||10 Antibodies|
|Intracellular Flow Cytometry (ICFC)||2 Antibodies|
|Neutralization (Neut)||4 Antibodies|
|Western Blotting (WB)||25 Antibodies|
|Antigen||Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C) Antibodies|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This TNFRSF13C antibody is un-conjugated Alternatives|
Blocking Reagent (BR), Flow Cytometry (FACS), Immunohistochemistry (IHC)
|6 references available|
|Supplier||Log in to see|
Product Details anti-TNFRSF13C AntibodyTarget Details TNFRSF13C Application Details Handling References for anti-TNFRSF13C Antibody (ABIN2664464) Images
|Purification||The antibody was purified by affinity chromatography.|
Target Details TNFRSF13CProduct Details anti-TNFRSF13C Antibody Application Details Handling References for anti-TNFRSF13C Antibody (ABIN2664464) Images back to top
|Alternative Name||CD268 (TNFRSF13C Antibody Abstract)|
|Background||BAFF (B cell-activating factor belonging to the TNF family) receptor (BAFF-R) is one of the three receptors that bind to BAFF. It is a type III transmembrane TNF receptor family member. BAFF-R is expressed at high levels in resting B cells and at lower levels in activated B cells, a small subset of activated/memory CD4+ T cells. It is a major mediator of BAFF dependent co-stimulatory response in peripheral B and T cells. It was reported that the mice expressing defective BAFF-R have disrupted B cell maturation. BAFF receptor appears to be particularly important for the regulation of normal B cell survival and maturation, as well as in the pathophysiology of aggressive B-cell malignancies and autoimmune diseases.|
Application DetailsProduct Details anti-TNFRSF13C Antibody Target Details TNFRSF13C Handling References for anti-TNFRSF13C Antibody (ABIN2664464) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFRSF13C Antibody Target Details TNFRSF13C Application Details References for anti-TNFRSF13C Antibody (ABIN2664464) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-TNFRSF13C Antibody (ABIN2664464)Product Details anti-TNFRSF13C Antibody Target Details TNFRSF13C Application Details Handling Images back to top
Fu, Lin-Lee, Pham et al.: "BAFF-R promotes cell proliferation and survival through interaction with IKKbeta and NF-kappaB/c-Rel in the nucleus of normal and neoplastic B-lymphoid cells." in: Blood, Vol. 113, Issue 19, pp. 4627-36, 2009 (PubMed).
Ng, Ng, Woehl et al.: "BAFF costimulation of Toll-like receptor-activated B-1 cells." in: European journal of immunology, Vol. 36, Issue 7, pp. 1837-46, 2006 (PubMed).
Ng, Sutherland, Newton et al.: "B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 173, Issue 2, pp. 807-17, 2004 (PubMed).
Thompson, Bixler, Qian et al.: "BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF." in: Science (New York, N.Y.), Vol. 293, Issue 5537, pp. 2108-11, 2001 (PubMed).
Schiemann, Gommerman, Vora et al.: "An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway." in: Science (New York, N.Y.), Vol. 293, Issue 5537, pp. 2111-4, 2001 (PubMed).
Batten, Groom, Cachero et al.: "BAFF mediates survival of peripheral immature B lymphocytes." in: The Journal of experimental medicine, Vol. 192, Issue 10, pp. 1453-66, 2000 (PubMed).
ImagesProduct Details anti-TNFRSF13C Antibody Target Details TNFRSF13C Application Details Handling References for anti-TNFRSF13C Antibody (ABIN2664464) back to top