anti-Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) Antibodies

ALOX5AP encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Additionally we are shipping ALOX5AP Kits (12) and ALOX5AP Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ALOX5AP 11690 P30355
ALOX5AP 29624 P20291
ALOX5AP 241 P20292
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Top anti-ALOX5AP Antibodies at antibodies-online.com

Showing 10 out of 67 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN185717 (0.1µg/ml) staining of Human U937 cell lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$429.84
Details
Human Goat Un-conjugated ELISA, IHC, IHC (p), WB Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Goat Un-conjugated ELISA, IHC, IHC (p) Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Goat Un-conjugated ELISA, IHC, WB   100 μg Log in to see 6 to 7 Days
$429.84
Details
Human Goat Un-conjugated ELISA, ICC, IF, WB Immunocytochemistry/Immunofluorescence: FLAP Antibody [ABIN268657] - Staining of FLAP using ABIN268657 in primary mouse fibroblast cells at 1:500 dilution and counterstained with Hoechst dye. Image courtesy of Lidia Hernandez, NCI Center for Cancer Research Immunohistochemistry-Paraffin: FLAP Antibody  - Staining of paraffin embedded Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 0.1 mg Log in to see 7 to 9 Days
$488.73
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: FLAP Antibody [NBP1-84666] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp.Lane 4: Human plasma (IgG/HSA depleted).Lane 5: Human liver tissue.Lane 6: Human tonsil tissue Immunohistochemistry-Paraffin: FLAP Antibody [NBP1-84666] - Staining of human lymph node shows strong cytoplasmic positivity in lymphoid cells outside the reaction centra. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Dog Goat Un-conjugated EIA, IHC (p), WB Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-ALOX5AP Antibody (Center) (ABIN392385) in K562 cell line lysates (35 µg/lane). ALOX5AP(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with ALOX5AP antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of ALOX5AP using HepG2 whole cell lysates 100 μL Log in to see 11 to 12 Days
$390.77
Details

Top referenced anti-ALOX5AP Antibodies

  1. Human Polyclonal ALOX5AP Primary Antibody for ELISA, ICC - ABIN268657 : Finkensieper, Kieser, Bekhite, Richter, Mueller, Graebner, Figulla, Sauer, Wartenberg: The 5-lipoxygenase pathway regulates vasculogenesis in differentiating mouse embryonic stem cells. in Cardiovascular research 2010 (PubMed)
    Show all 3 Pubmed References

  2. Dog (Canine) Polyclonal ALOX5AP Primary Antibody for ELISA, WB - ABIN547761 : Kaaman, Rydén, Axelsson, Nordström, Sicard, Bouloumié, Langin, Arner, Dahlman: ALOX5AP expression, but not gene haplotypes, is associated with obesity and insulin resistance. in International journal of obesity (2005) 2006 (PubMed)

  3. Human Polyclonal ALOX5AP Primary Antibody for IHC, IHC (p) - ABIN4312085 : Perisic, Hedin, Razuvaev, Lengquist, Osterholm, Folkersen, Gillgren, Paulsson-Berne, Ponten, Odeberg, Hedin: Profiling of atherosclerotic lesions by gene and tissue microarrays reveals PCSK6 as a novel protease in unstable carotid atherosclerosis. in Arteriosclerosis, thrombosis, and vascular biology 2013 (PubMed)

  4. Human Polyclonal ALOX5AP Primary Antibody for ELISA - ABIN547306 : Maier, Tausch, Hoernig, Coste, Schmidt, Angioni, Metzner, Groesch, Pergola, Steinhilber, Werz, Geisslinger: Celecoxib inhibits 5-lipoxygenase. in Biochemical pharmacology 2008 (PubMed)

  5. Human Polyclonal ALOX5AP Primary Antibody for WB - ABIN550379 : Dixon, Diehl, Opas, Rands, Vickers, Evans, Gillard, Miller: Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. in Nature 1990 (PubMed)
    Show all 2 Pubmed References

  6. Human Polyclonal ALOX5AP Primary Antibody for IF (p), IHC (p) - ABIN872471 : Elias, Ferré, Vilà, Muñoz, Casellas, Garcia, Molas, Agudo, Roca, Ruberte, Bosch, Franckhauser: ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance. in Diabetes 2016 (PubMed)

More Antibodies against ALOX5AP Interaction Partners

Mouse (Murine) Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) interaction partners

  1. ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance

  2. Data indicate that a single amino acid mutation was sufficient to reverse the speciation observed in wild type 5-Lipoxygenase activating protein (FLAP).

  3. BRP-7 potently suppresses leukotriene biosynthesis by interacting with FLAP in mouse peritonitis model.

  4. FLAP regulates phosphorylation of tau protein via modulating GSK-3beta activity.

  5. This study demonistrated that a a novel role for FLAP in the pathogenesis of anxiety-like behavior in mice.

  6. Deletion of myeloid cell FLAP markedly attenuates the proliferative response to vascular injury, while preserving endothelial integrity.

  7. A FLAP inhibitor given during critical window periods may prevent oxygen induced aberration of pulmonary alveolarization in a dose- and time-dependent manner.

  8. the 5-LO pathway emerges early during embryonic stem cell differentiation into cells of the myeloid lineage

  9. Adipose tissue from obese mice, compared with that from lean mice, exhibited increased 5-LO activating protein

  10. Data show that 5-lipoxygenase activity increases during senescence-like growth arrest via a p53/p21-dependent pathway in both human and mouse embryo fibroblasts.

  11. Altered 5-lipoxygenase is associated with obesity and bone traits

  12. This observation supports the hypothesis that 5-LO may be involved in diseases of the brain associated with aging.

  13. Important role of FLAP/leukotriene pathway in adaptive immunological circuits in vascular and adipose tissue inflammation. May be key regulator of T-cell-driven inflammatory and possible target in treatment of atherosclerosis and metabolic disease.

  14. identify multiprotein complexes for leukotriene synthesis on the outer and inner nuclear membranes of mast cells and neutrophils, centered on the 5-Lipoxygenase-Activating Protein and 5-Lipoxygenase

  15. FLAP mRNA is abundantly expressed in fetal mouse liver from e11.5 until delivery.

Human Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) interaction partners

  1. Phosphate steering is an unappreciated FLAP function that enforces 5'-flap specificity and catalysis, preventing genomic instability.

  2. This meta-analysis indicates that ALOX5AP rs17222919-1316T/G may be a protective factor against stroke.

  3. Indicate a potential protective role of ALOX5AP and 5-arachidonate lipoxygenase gene in diabetes type 2 pathogenesis.

  4. No significant association was found between ALOX5AP rs10507391 polymorphism and ischemic stroke risk in males. Moreover, ALOX5AP rs10507391 polymorphism was not associated with cardioembolic ischemic stroke risk.

  5. rs17222919 of ALOX5AP is a potential genetic protective factor against ischemic stroke in the Chinese population

  6. This study revealed that epistatic interaction among the ALOX5, ALOX5AP and MPO genes played a significant role in vulnerability to ischemic stroke.

  7. The results the study indicate that SNP genetic variants of ALOX5AP might play a role in the development of SSc-related pulmonary fibrosis and ventilatory dysfunction.

  8. The observation that the coexpression of FLAP with a subset of the 5-LOX mutants restores 5-LOX-wild-type (wt)-like levels of products formed in intact cells suggests a physical protein-protein interaction, beyond colocalization, of 5-LOX and FLAP.

  9. Meta-analysis suggests that the A allele at the ALOX5AP SG13S114 polymorphism is a protective factor for the ischemic stroke in the European population

  10. Genetic polymorphisms of T-1131C APOA5 and ALOX5AP SG13S114 can be considered risk factors for the susceptibility to ischemic stroke in Morocco.

  11. Data indicate that a single amino acid mutation was sufficient to reverse the speciation observed in wild type 5-Lipoxygenase activating protein (FLAP).

  12. No association was found between single-nucleotide polymorphisms of ALOX5AP or PDE4D and the risk of overall ischemic stroke in a southeastern Chinese population. The ALOX5AP gene might be related to ischemic stroke incidence in females.

  13. Genetic interaction of CD80 and ALOX5AP was observed in systemic lupus erythematosus in Asian populations.

  14. findings show that several enzymes known to be involved in the biosynthesis of proinflammatory LTs, such as FLAP and cPLA2alpha, also contribute to LX and Rv formation

  15. The results of this study supported the association of the epistatic interactions of ALOX5AP, THBD, and KNG1 and present novel evidence for the main effect of KNG1 gene on IS susceptibility

  16. results of the meta-analysis indicate that ALOX5AP rs10507391/SG13S114 A>T polymorphism is not associated with the risk of cerebral infarction in the Chinese population.

  17. Genetic polymorphisms of ALOX5AP and CYP3A5 increase susceptibility to ischemic stroke and are associated with atherothrombotic events in stroke patients.

  18. Our study provides evidence that the promoter single nucleotide polymorphism (SNP) rs17222919 of the ALOX5AP is a potential genetic protective factor for IS in the Chinese Han population.

  19. Report no association between ALOX5AP SNPs and atherosclerotic plaque phenotypes.

  20. THE 5-LOX interface involving the four cysteines 159, 300, 416 and 418 is important for the translocation to the nuclear membrane and the colocalization with FLAP.

Cow (Bovine) Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) interaction partners

  1. ALOX5AP, CPNE3, IL1R2, IL6, TLR2, TLR4, and THY1 were upregulated in blood polymorphonuclear cells in negative energy balance versus positive energy balance cows.

ALOX5AP Antigen Profile

Protein Summary

This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Gene names and symbols associated with ALOX5AP

  • arachidonate 5-lipoxygenase-activating protein (alox5ap) antibody
  • arachidonate 5-lipoxygenase activating protein (ALOX5AP) antibody
  • arachidonate 5-lipoxygenase activating protein (alox5ap) antibody
  • arachidonate 5-lipoxygenase activating protein (Alox5ap) antibody
  • al5ap antibody
  • ALOX5AP antibody
  • fj65d02 antibody
  • FLAP antibody
  • wu:fj65d02 antibody
  • zgc:63982 antibody

Protein level used designations for ALOX5AP

arachidonate 5-lipoxygenase-activating protein , Arachidonate 5-lipoxygenase-activating protein , MK-886-binding protein , arachidonate 5 lipoxygenase activating protein , 5-lipoxygenase-activating protein FLAP , FLAP , arachidonate 5-lipoxygenase activating protein , 5-lipoxygenase-activating protein

GENE ID SPECIES
337376 Danio rerio
452520 Pan troglodytes
477323 Canis lupus familiaris
613083 Xenopus (Silurana) tropicalis
770904 Gallus gallus
100286557 Salmo salar
100305320 Oncorhynchus mykiss
100009413 Oryctolagus cuniculus
443326 Ovis aries
11690 Mus musculus
29624 Rattus norvegicus
241 Homo sapiens
613869 Bos taurus
100034178 Equus caballus
397392 Sus scrofa
713170 Macaca mulatta
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