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Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Additionally we are shipping DEP Domain Containing 2 Antibodies (14) and DEP Domain Containing 2 Kits (7) and many more products for this protein.
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MiR (show MLXIP Proteins)-338-3p suppresses the TNF-alpha (show TNF Proteins)-induced lipogenesis in sebocytes by targeting PREX2a and down-regulating PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling.
Data suggest that PREX1 and PREX2 share similarities in amino acid sequence, domain structure, activation by PIP(3) [phosphatidylinositol 3,4,5-triphosphate] and G-protein-coupled receptors beta/gamma subunits; expression of PREX1 and PREX2 is altered in many cancers. [REVIEW]
complex signaling mechanisms that involve PREX2, PI3K/AKT/PTEN and downstream epigenetic machinery to deregulate expression of key cell cycle regulators
PREX2 was identified as a frequently mutated gene in human melanoma. .. mutation of PREX2 can accelerate human melanoma growth.
The rapid tumor onset observed in this replication attempt, compared to the original study, makes the detection of accelerated tumor growth in PREX2 expressing NRAS (show NRAS Proteins)(G12D) melanocytes extremely difficult.
Elevated PREX2 protein expression is associated with pathogenesis of hepatocellular carcinoma.
The results of the present study suggested that PREX2a may act as an oncogene (show RAB1A Proteins) in osteosarcoma via the inhibition of PTEN activity and activation of PI3K (show PIK3CA Proteins) signaling.
findings identify PREX2 as a mediator of NRAS-mutant melanoma development that acts through the PI3K/PTEN/Akt pathway to regulate gene expression of a cell cycle regulator
second messengers activate the Rac1 signal, which sets in motion a cascade whereby PAKs phosphorylate and negatively regulate PREX2 to decrease Rac1 activation.
PREX2 mutants are likely selected in cancer to escape PTEN-mediated inhibition of invasion.
P-REX2 PH-domain-mediated inhibition of PTEN has a role in regulating insulin (show INS Proteins) sensitivity and glucose homeostasis
This study demonistrated that the P-Rex2, a GEF (show ARHGEF2 Proteins) that specifically activates Rac (show AKT1 Proteins) small GTPases, is expressed in a cell- and synapse-specific manner in the retina.
PI3K/P-Rex/Rac (show AKT1 Proteins) pathway is required for late phase long-term potentiation in the mouse cerebellum
P-Rex1 and P-Rex2 are important regulators of Purkinje cell morphology and cerebellar function
Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein- coupled receptors and phosphoinositide 3-kinase (By similarity).
DEP domain-containing protein 2
, PtdIns(3,4,5)-dependent Rac exchanger 2
, phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
, DEP domain containing 2
, ptdIns(3,4,5)-dependent Rac exchanger 2