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Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types.
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Human Monoclonal Desmoglein 3 Primary Antibody for ICC, IF - ABIN4305016
Proby, Ota, Suzuki, Koyasu, Gamou, Shimizu, Wahl, Wheelock, Nishikawa, Amagai: Development of chimeric molecules for recognition and targeting of antigen-specific B cells in pemphigus vulgaris. in The British journal of dermatology 2000
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Human Monoclonal Desmoglein 3 Primary Antibody for ICC, FACS - ABIN151179
Wu, Stanley, Cotsarelis: Desmoglein isotype expression in the hair follicle and its cysts correlates with type of keratinization and degree of differentiation. in The Journal of investigative dermatology 2003
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Human Monoclonal Desmoglein 3 Primary Antibody for IHC (fro), IP - ABIN2473333
Smith, Richards, Yasin, Sangster, Sridaran: Changes in rat luteal ultrastructure and P450scc mRNA and protein content after in vivo treatment with a gonadotropin-releasing hormone agonist. in Biology of reproduction 1991
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Human Monoclonal Desmoglein 3 Primary Antibody for FACS, IF - ABIN5576864
Mahoney, Hu, Brennan, Bazzi, Christiano, Wahl: Delineation of diversified desmoglein distribution in stratified squamous epithelia: implications in diseases. in Experimental dermatology 2006
flotillin (show FLOT2 Antibodies) has a role in desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes
our findings suggest that Dsg3 functions as a key in cell-cell adhesion through at least a mechanism of regulating E-cadherin (show CDH1 Antibodies) membrane trafficking
Desmoglein 3 Order and Dynamics in Desmosomes
Data indicate that all 3 monoclonal antibodies (mAbs) targeted the same extracellular cadherin (EC) domain on desmoglein 3 (Dsg3), caused Dsg3 internalization in primary keratinocytes, and caused suprabasal blisters in skin.
DSG3 was a key prognostic factor and predictor for neoadjuvant concurrent chemoradiotherapy response in rectal cancer patients.
Treg cells exert a clear down-regulatory effect on the Dsg3-driven T-cell response and, accordingly, the formation of Dsg3-specific IgG antibodies
Data identify DSG3 as a negative prognostic biomarker in resected pancreatic ductal adenocarcinoma, as high DSG3 expression is associated with poor overall survival and poor tumour-specific survival.
this study directly demonstrates the occurrence of desmoglein 3 molecules outside of desmosomes and reveales that the adhesive properties of these molecules do differ depending on their localization.
DSG2 (show DSG2 Antibodies) and DSG3 might be potential diagnostic markers for squamous cell carcinoma of the lung and DSG3 could be a potential differentiation marker for lung cancer.
alterations of their expression suggest a role of Dsg3 and gamma-catenin (show JUP Antibodies) (additionally to E-cadherin (show CDH1 Antibodies)/beta-catenin (show CTNNB1 Antibodies)) as biomarkers of malignant transformation risk of oral dysplasia and the biological behavior (aggressiveness) of oral cancer, respectively
Desmoglein 3 deficiency in mice leads to a phenotype characterized by cyclic alopecia in addition to the dramatic skin and mucocutaneous acantholysis observed in pemphigus patients.
Dsg3, via p38 MAPK (show MAPK14 Antibodies), regulates the spatial distribution of the keratin filament network and stabilizes cell adhesion.
Squamous metaplasia after pulmonary epithelial injury may play a crucial role in redirecting the skin-specific autoimmune reaction to the lungs in paraneoplastic pemphigus (PNP (show NP Antibodies)).
Dsg3 deficiency results in perturbation of the desmosomal network at the transcriptional, translational, and interaction level, kinase activation, proteinase-mediated degradation, and hyper-adhesion. (Review)
Thus, Dsg3 does not display a clear function as a tumor suppressor in these mouse skin cancer models
IgG and IgM (show CD40LG Antibodies) antibodies against desmoglein 3 have a pathogenic role in blister formation in pemphigus vulgaris
the adult passive transfer mouse model is ideally suited for detailed studies of Dsg3 antibody-mediated signaling in adult skin.
These data indicate a contribution of Dsg (show DSG1 Antibodies) depletion to pemphigus vulgaris pathogenesis dependent on Ca(2 (show CA2 Antibodies)+)-induced differentiation.
Transgenic expression of Dsg1 (show DSG1 Antibodies) rescued the severe B6-Dsg3(-/-) phenotype and provided a syngeneic mouse model of pemphigus vulgaris.
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.
desmoglein 3 (pemphigus vulgaris antigen)
, desmoglein 3
, 130 kDa pemphigus vulgaris antigen
, 130-kD pemphigus vulgaris antigen
, cadherin family member 6
, pemphigus vulgaris antigen
, 130 kDa pemphigus vulgaris antigen homolog
, desmoglein 3 preprotein