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The protein encoded by MCM9 is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication.
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stalled replication forks can be restarted in S phase via homologous recombination using MCM8 (show MCM8 Antibodies)-9 as an alternative replicative helicase.
Significant number of potentially damaging and novel variants in MCM9 in primary ovarian insufficiency; multiallelic association with variants in DDR (show DDR1 Antibodies) and MCM8 (show MCM8 Antibodies)-MCM9 interactome genes.
Study identified fifteen variants that included six common SNPs and nine variants of unknown significance (VUS) in MCM9 gene. However VUS occur in MCM9 in a small proportion of Lynch-like syndrome (LLS) patients and MCM9 mutations are unlikely to explain most LLS cases.
Data show that the two affected sisters were homozygous for the mutation of MCM9 gene, encoding the minichromosome maintenance complex component 9.
MCM9 loading onto chromatin is MSH2 (show MSH2 Antibodies)-dependent, and in turn MCM9 stimulates the recruitment of MLH1 (show MLH1 Antibodies) to chromatin, revealing a role for MCM9 and its helicase activity in DNA mismatch repair.
Autosomal-recessive variants in MCM9 cause a genomic-instability syndrome associated with hypergonadotropic hypogonadism (show LHCGR Antibodies) and short stature.
Chromatin immunoprecipitation analysis using human DR-GFP cells demonstrated that MCM8 (show MCM8 Antibodies) and MCM9 proteins are rapidly recruited to DNA damage sites and promote RAD51 (show RAD51 Antibodies) recruitment.
A novel alternatively spliced variant of MCM9 is specifically induced after exposure to Mitomycin C. Expression is cell-cycle regulated and induced in S-phase.
Identified a novel MCM family gene, MCM9, by using bioinformatics; mouse MCM9 mRNA was upregulated by transcription factor E2E1 and serum stimulation in NIH3T3 cells.
We also show that the very recently reported human MCM9 protein (HsMCM9), which resembles a truncated MCM-like protein missing a part of the MCM2-7 (show MCM2 Antibodies) signature domain, is an incomplete form of the full length HsMCM9 described here.
genetic studies of DNA damage response pathways that underlie germ cell depletion in mice mutant for minichromosome maintenance 9
MCM8 (show MCM8 Antibodies) and MCM9 form a complex and that they coregulate their stability.
Minichromosome maintenance helicase (show DNA2 Antibodies) paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression.
Mcm8 (show MCM8 Antibodies) and Mcm9 form a dimeric complex in Xenopus laevis egg extract that is not essential for DNA replication initiation.
Cdt1 (show CDT1 Antibodies), with its two opposing regulatory binding factors MCM9 and geminin (show GMNN Antibodies), appears to be a major platform on the pre-replication complexes to integrate cell-cycle signals.
The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1.
DNA helicase MCM9
, DNA replication licensing factor MCM9
, mini-chromosome maintenance deficient domain-containing protein 1
, minichromosome maintenance deficient domain containing 1
, mini-chromosome maintenance deficient 9
, minichromosome maintenance 9
, minichromosome maintenance complex component 9
, LOW QUALITY PROTEIN: DNA helicase MCM9
, Minichromosome maintenance 9