anti-Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 2 (KCND2) Antibodies

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Additionally we are shipping KCND2 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCND2 16508 Q9Z0V2
KCND2 3751 Q9NZV8
KCND2 65180 Q63881
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Top anti-KCND2 Antibodies at antibodies-online.com

Showing 10 out of 103 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mammalian Mouse Un-conjugated ISt, IHC, WB   5 mL Log in to see 2 to 6 Days
$394.53
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-KCND2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Human heart 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ELISA, FACS, WB Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 2:Western blot analysis using KCND2 mAb against human KCND2 (AA: 27-184) recombinant protein. (Expected MW is 42.3 kDa) Dilution: 1/500 - 1/2000 100 μL Log in to see 8 to 11 Days
$577.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue reacted with  KCND2 Antibody (N-term) followed which was peroxidase conjugated to the secondary antibody and followed by DAB staining. Western blot analysis of KCND2 Antibody (N-term) in K562 cell line lysates (35ug/lane).This demonstrates the KCND2 antibody detected the KCND2 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Kv4.2/KCND2 (Ab-616) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated ELISA, WB Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 2:Western blot analysis using KCND2 mAb against human KCND2 (AA: 27-184) recombinant protein. (Expected MW is 42.3 kDa) Dilution: 1/500 - 1/2000 100 μL Log in to see 8 to 11 Days
$577.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of Kv4.2/KCND2 (Phospho-Ser616) using MDA-MB-435 whole cell lysates 100 μL Log in to see 11 to 12 Days
$450.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of KCND2 using MCF7 whole  lysates. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$467.50
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Immunohistochemistry-Paraffin: Kv4.2 Antibody [NBP1-87708] - Staining of human bronchus shows moderate cytoplasmic positivity in respiratory epithelial cells. Western Blot: Kv4.2 Antibody [NBP1-87708] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp 0.1 mL Log in to see 10 to 13 Days
$494.38
Details

Top referenced anti-KCND2 Antibodies

  1. Mammalian Monoclonal KCND2 Primary Antibody for ISt, IHC - ABIN1304770 : Mulholland, Spencer, Hu, Kroener, Chandler: Neuroplasticity of A-type potassium channel complexes induced by chronic alcohol exposure enhances dendritic calcium transients in hippocampus. in Psychopharmacology 2015 (PubMed)
    Show all 64 Pubmed References

  2. Human Polyclonal KCND2 Primary Antibody for WB - ABIN538248 : Roberds, Tamkun: Cloning and tissue-specific expression of five voltage-gated potassium channel cDNAs expressed in rat heart. in Proceedings of the National Academy of Sciences of the United States of America 1991 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal KCND2 Primary Antibody for IHC, IHC (p) - ABIN4329445 : Chang, Atzmon, Bergman, Brugmann, Atwood, Chang, Barzilai: Identification of genes promoting skin youthfulness by genome-wide association study. in The Journal of investigative dermatology 2014 (PubMed)

More Antibodies against KCND2 Interaction Partners

Mouse (Murine) Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 2 (KCND2) interaction partners

  1. we are investigating the effects of hyperoxia on atrial electrophysiology using whole-cell patch-clamp electrophysiology experiments along with assessment of Kv1.5, Kv4.2, and KChIP2 transcripts and protein profiles using real-time quantitative RT-PCR and Western blotting.

  2. The results reveal an important role for miR-324-5p-mediated silencing of Kv4.2 in seizure onset.

  3. Ca(2+)/calcineurin (CaN)/nuclear factor of activated T-cells (NFAT) c4 axis is required for neuritin-induced Kv4.2 transcriptional expression and potentiation of IA densities in cerebellum granule neurons.

  4. Result suggests that the memory type supported by neurons may depend critically on the phosphorylation of specific K+ channels at single residues.

  5. Data show that suprachiasmatic nucleus (SCN) explants from potassium channel Kv1.4(-/-)period2 protein Per2(Luc) and potassium channel Kv4.2(-/-) period2 protein Per2(Luc) mice have significantly shorter circadian periods in PER2 rhythms.

  6. Data show that potassium channel Kv4.3 outward current is presented incardiomyocyte lacking the potassium channel Kv4.2 gene (Kv4.2-/-).

  7. This study demonstrated that Dendritic hyperexcitability induced by Kv4.2 deficiency exacerbated behavioral deficits and increased epileptiform activity amyloid protein precursor mutation mice.

  8. Real-time RT-PCR and Western blotting revealed that Kv4.2 expression was downregulated in both BSO-treated groups, whereas KChIP2 expression was downregulated only in the H/M-Sod2(+/-)+BSO group (P<0.05).

  9. WT PrP(C), in a DPP6-dependent manner, modulated Kv4.2 channel properties, causing an increase in peak amplitude

  10. MiR-301a may be a central regulator for the expression of Kv4.2 in diabetes.

  11. The experiments here demonstrate that Kv4.2, Kv4.3 and Kv1.4 all contribute to the generation of potassium channels in mature cortical pyramidal (CP) neurons; these channels play distinct roles in regulating the intrinsic properties of mature CP neurons.

  12. Kv4.2 regulation of excitability determines synaptic maturation site in CA1 hippocampal pyramidal neurons.

  13. Kv1.4- and Kv4.2-encoded I(A) channels regulate the intrinsic excitability of SCN neurons during the day and night and determine the period and amplitude of circadian rhythms in SCN neuron firing and locomotor behavior.

  14. The combined down-regulation of Kv4.2, Kv1.5 and KChIP2 prior to the onset of HF may play an important role in the premature sudden death in this DCM model.

  15. our findings suggest an important role for Kv4.2 channels in hippocampal-dependent learning and memory

  16. The results presented here identify Navbeta1 as a component of native neuronal Kv4.2-encoded I(A) channel complexes and a novel regulator of I(A) channel densities and neuronal excitability.

  17. In the presence of DPP6 or DPP10, cell surface Kv4.2 protein expression is selectively increased.

  18. For the other type of synaptic plasticity, long-term depression, the threshold was significantly increased in Kv4.2-/- mice

  19. we tested Kv4.2 knockout mice in the Morris water maze to assess their spatial reference acquisition and recall abilities

  20. Fragile X mental retardation protein 1 (Fmr1) suppression of Kv4.2 is revealed by elevation of Kv4.2 in neurons from Fmr1 knockout mice and in neurons expressing Kv4.2-3'-untranslated region (UTR) that binds Fmr1.

Human Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 2 (KCND2) interaction partners

  1. KCND2 upregulation is a valuable prognostic biomarker in gastric cancer patients, in terms of overall survival and recurrence-free survival.

  2. A mutation, V404M, in the Kv4.2 channel subunit is associated with infant-onset epilepsy and autism. V404M enhances inactivation of channels that have not opened but dramatically impairs inactivation after opening. Authors show that increased side-chain volume is largely responsible for these seemingly paradoxical effects.

  3. Our results do not support the notion that accessory KChIP2 binding is a prerequisite for dendritic trafficking and functional surface expression of Kv4.2 channels, however, accessory KChIP2 binding may play a potential role in Kv4.2 modulation during intrinsic plasticity processes.

  4. Ca(2+)/calcineurin (CaN)/nuclear factor of activated T-cells (NFAT) c4 axis is required for neuritin-induced Kv4.2 transcriptional expression and potentiation of IA densities in cerebellum granule neurons.

  5. closed-state inactivation in Kv4.2 channels is a multistep process

  6. The study provides the first piece of evidence for the role of H2S in regulating Ito potassium channels and also the specific motif in an ion channel labile for H2S regulation.

  7. The stoichiometry of the Kv4.2-DPP10 complex was variable depending on the relative expression level of each subunit, with a preference for 4:2 stoichiometry

  8. The findings of this study suggest that variations in KCND2 genes are associated with both mild and severe persistent breast pain after breast cancer surgery.

  9. A rare genetic mutation of the KCND2 gene, p.D612N, was identified in a single patient. Co-expression of mutant and wild-type KCND2 with KChIP2 demonstrated a gain-of-function phenotype.

  10. S-glutathionylation of an auxiliary subunit confers redox sensitivity to Kv4 channel inactivation.

  11. study identified a de novo variant p.Val404Met in KCND2 in a family with identical twins affected with autism and severe seizures; findings suggest KCND2 is the causal gene for epilepsy in this family and has a role in the etiology of autism

  12. Subunit counting by single-molecule imaging revealed that the bound number of KChIP4 in each Kv4.2.KChIP4 complex was dependent on the expression level of KChIP4.

  13. reflected in the immunoblotting data KV4.2 receptors were detected at higher levels of expression in patient with cortical dysplasia with intractable epilepsy.

  14. KCND2 is expressed in human skin, but has not been associated with aging.

  15. WT PrP(C), in a DPP6-dependent manner, modulated Kv4.2 channel properties, causing an increase in peak amplitude

  16. Our results support the hypothesis that KChIPs enhances Kv4.2 functional expression by a 1 : 1 suppression of the N-terminal FERN domain and by producing additional positive regulatory effects on functional channel expression.

  17. Autoantibodies from patients with encephalitis are specific for DPPX (a subunit of Kv4.2) without reacting to Kv4.2.

  18. Seizures in Kv4.2 transgenic mice rapidly redistribute K+ channel subunit Kv4.2 to the neuronal surface, implicating a molecular substrate for the increased K+ current.

  19. KChIP2 differentially regulates total and cell surface Kv4.2 protein expression and Kv4 current densities.

  20. MiRP3 modulates Kv4.2 current activation, inactivation and recovery from inactivation. MiRP3 shifts the half-maximal voltage for activation and slows time to peak ~ 100%.

KCND2 Antigen Profile

Protein Summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels.

Gene names and symbols associated with KCND2

  • potassium voltage-gated channel subfamily D member 2 (KCND2) antibody
  • potassium voltage-gated channel, Shal-related subfamily, member 2 (KCND2) antibody
  • potassium voltage-gated channel subfamily D member 2 (kcnd2) antibody
  • potassium voltage-gated channel, Shal-related subfamily, member 2 (kcnd2) antibody
  • potassium voltage-gated channel, Shal-related family, member 2 (Kcnd2) antibody
  • potassium voltage-gated channel subfamily D member 2 (LOC101669961) antibody
  • potassium voltage-gated channel subfamily D member 2 (Kcnd2) antibody
  • AI839615 antibody
  • AW555701 antibody
  • DKFZp459P1550 antibody
  • KCND2 antibody
  • KV4.2 antibody
  • mKIAA1044 antibody
  • R75121 antibody
  • RK5 antibody
  • Shal1 antibody
  • si:dkey-24j9.3 antibody
  • si:dkeyp-97c5.3 antibody

Protein level used designations for KCND2

potassium voltage-gated channel, Shal-related subfamily, member 2 , potassium voltage-gated channel Sha1-related subfamily member 2 , potassium voltage-gated channel subfamily D member 2 , zShal2 , potassium channel Kv4.2 , voltage-gated potassium channel subunit Kv4.2 , voltage-gated potassium channel Kv4.2 , voltage-sensitive potassium channel , Potassium voltage-gated channel subfamily D member 2 , Voltage-gated potassium channel subunit Kv4.2 , potassium channel alpha subunit Kv4.2 , potassium voltage gated channel, Shal-related family, member 2

GENE ID SPECIES
100012747 Monodelphis domestica
100038027 Sus scrofa
100543035 Meleagris gallopavo
100562429 Anolis carolinensis
100603164 Nomascus leucogenys
472489 Pan troglodytes
491424 Canis lupus familiaris
540416 Bos taurus
570188 Danio rerio
574361 Macaca mulatta
100174287 Pongo abelii
16508 Mus musculus
3751 Homo sapiens
101669961 Mustela putorius furo
100008841 Oryctolagus cuniculus
65180 Rattus norvegicus
374143 Gallus gallus
Selected quality suppliers for anti-KCND2 (KCND2) Antibodies
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