anti-Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) Antibodies

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. Additionally we are shipping Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) Proteins (13) and Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) Kits (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SDHB 6390 P21912
SDHB 67680 Q9CQA3
SDHB 298596 P21913
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Top anti-Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) Antibodies at antibodies-online.com

Showing 10 out of 142 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SDHB Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Jurkat cell lysate SDHB is supported by BioGPS gene expression data to be expressed in Jurkat Host:  Rabbit  Target Name:  SDHB  Sample Tissue:  Human Fetal Lung  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-SDHB antibody, Western blotting All lanes: Anti SDHB  at 0.5ug/ml Lane 1: Rat Testis Tissue Lysate at 50ug Lane 2: Rat Cardiac Muscle Tissue Lysate at 50ug Lane 3: Jurkat Whole Cell Lysate at 40ug Predicted bind size: 32KD Observed bind size: 32KD Anti-SDHB antibody, IHC(P) IHC(P): Rat Cardiac Muscle Tissue 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Goat Un-conjugated ELISA, WB ABIN185447 (0.03µg/ml) staining of Human Liver lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$358.02
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image SDHB antibody [C2C3], C-term detects SDHB protein by Western blot analysis. A. 30 µg Neuro2A whole cell lysate/extract 12 % SDS-PAGE SDHB antibody [C2C3], C-term , dilution: 1:1000 IHC-P Image SDHB antibody [C2C3], C-term detects SDHB protein at mitochindria on human colon carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human colon carcinoma. SDHB antibody [C2C3], C-term , diluted at 1:500. 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Rabbit Un-conjugated ELISA, IHC (p), WB Immunohistochemistry (IHC) analysis of paraffin-embedded Human Muscle, antibody was diluted at 1:100. 100 μL Log in to see 16 Days
$181.73
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: SDHB Antibody [NBP1-54154] - ICC staining of SDHB in HeLa cells with FITC (green). Nuclei were counterstained with Dapi (blue). Western Blot: SDHB Antibody [NBP1-54154] - Detection of SDHB in mouse kidney lysate. 0.1 mL Log in to see 7 to 9 Days
$415.44
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), SimWes, WB Simple Western: SDHB Antibody [NBP1-87069] - Simple Western lane view shows a specific band for SDHB in 0.2 mg/ml of RT-4 (left) and U-251MG sp (right) lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system. Simple Western: SDHB Antibody [NBP1-87069] - Electropherogram image(s) of corresponding Simple Western lane view. SDHB antibody was used at 1:20 dilution on RT-4 and U-251MG sp lysates(s). 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Goat Un-conjugated ELISA, IHC, IHC (p), WB Human Heart (formalin-fixed, paraffin-embedded) stained with SDHB antibody ABIN364266 at 5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. Anti-SDHB antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of SDHB using anti-SDHB antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: human MCF-7 whole cell lysates, Lane 2: human A549 whole cell lysates, Lane 3: human SGC-7901 whole cell lysates, Lane 4: rat brain tissue lysates, Lane 5: rat heart tissue lysates, Lane 6: mouse brain tissue lysates, Lane 7: mouse heart tissue lysates.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-SDHB antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for SDHB at approximately 32KD. The expected band size for SDHB is at 32KD. IHC analysis of SDHB using anti-SDHB antibody . SDHB was detected in paraffin-embedded section of mouse small intestine tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti-SDHB Antibody  overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen. 100 μg Log in to see 4 to 6 Days
$280.00
Details

Top referenced anti-Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) Antibodies

  1. Human Polyclonal SDHB Primary Antibody for ICC, IF - ABIN4352356 : van Nederveen, Gaal, Favier, Korpershoek, Oldenburg, de Bruyn, Sleddens, Derkx, Rivière, Dannenberg, Petri, Komminoth, Pacak, Hop, Pollard, Mannelli, Bayley, Perren, Niemann, Verhofstad, de Bruïne et al.: An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis. ... in The Lancet. Oncology 2009 (PubMed)
    Show all 15 Pubmed References

  2. Human Polyclonal SDHB Primary Antibody for WB - ABIN1881781 : Cerecer-Gil, Figuera, Llamas, Lara, Escamilla, Ramos, Estrada, Hussain, Gaal, Korpershoek, de Krijger, Dinjens, Devilee, Bayley: Mutation of SDHB is a cause of hypoxia-related high-altitude paraganglioma. in Clinical cancer research : an official journal of the American Association for Cancer Research 2010 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal SDHB Primary Antibody for ICC, IF - ABIN4352351 : Morton, Beltram, Carter, Michailidou, Gorjanc, McFadden, Barrios-Llerena, Rodriguez-Cuenca, Gibbins, Aird, Moreno-Navarrete, Munger, Svenson, Gastaldello, Ramage, Naredo, Zeyda, Wang, Howie, Saari et al.: Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness. ... in Nature medicine 2016 (PubMed)
    Show all 2 Pubmed References

  4. Cow (Bovine) Polyclonal SDHB Primary Antibody for WB - ABIN2783181 : Cascón, Landa, López-Jiménez, Díez-Hernández, Buchta, Montero-Conde, Leskelä, Leandro-García, Letón, Rodríguez-Antona, Eng, Neumann, Robledo: Molecular characterisation of a common SDHB deletion in paraganglioma patients. in Journal of medical genetics 2008 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal SDHB Primary Antibody for ELISA, WB - ABIN269796 : Selak, Armour, MacKenzie, Boulahbel, Watson, Mansfield, Pan, Simon, Thompson, Gottlieb: Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. in Cancer cell 2005 (PubMed)

More Antibodies against Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) Interaction Partners

Fruit Fly (Drosophila melanogaster) Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) interaction partners

  1. sdhB mutant is hypersensitive to oxygen and displays hallmarks of a progeroid syndrome

Human Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) interaction partners

  1. The overall penetrance of succinate dehydrogenase B (SDHB) mutations is estimated to be 21% at age 50 and 42% at age 70 when adequately corrected for ascertainment.

  2. Germline SDHB mutation is associated with Pheochromocytoma and Paraganglioma.

  3. Data suggest that low expression of SDHB in metastatic lesions is associated with longer overall survival in patients with advanced ileal well-differentiated neuroendocrine tumors with lymph node or liver metastases.

  4. Results identified a high frequency of germline mutation in SDHB gene in patients presenting with bladder paraganglioma.

  5. automation, reproducibility, and cost efficiency of SDHB IHC offer advantages over the labor-intensive histochemical method requiring frozen sections

  6. We report a unique case of an SDH (show SARDH Antibodies)-deficient GIST case with an activating PDGFRA (show PDGFRA Antibodies) mutation. Oncogenic mutations in GIST are generally mutually exclusive; however documented exceptions exist which may have diagnostic and therapeutic implications.

  7. Mutation in the SDHB gene is associated with mediastinal paraganglioma.

  8. We report for the first time the presence of both TFE3 (show TFE3 Antibodies) translocation and SDHB mutation in the same renal cell carcinoma (show MOK Antibodies) tumor.

  9. Heterozygous germ line mutations in SDHB neutrophil survival is independent of HIF-1alpha (show HIF1A Antibodies) expression and linked to uncoupling of the mitochondrial electron transport chain.

  10. miR (show MLXIP Antibodies)-142-5p up-regulation in colorectal cancer probably facilitates generation of aerobic glycolysis by reducing SDHB expression.

Pig (Porcine) Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) interaction partners

  1. tissue expression analysis indicated that that swine SDHB, SNRPA (show SNRPA Antibodies) and CRYBB1 (show CRYBB1 Antibodies) gene were differentially expressed in tissues including fat, lung, muscle, small intestine, kidney, large intestine, spleen and liver

Mouse (Murine) Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) interaction partners

  1. Data show that lack of succinate dehydrogenase (SDH (show SDHA Antibodies)) activity commits cells to consume extracellular pyruvate.

  2. Using Sdhb(+/-) mice, we provide evidence that pituitary hyperplasia in SDHx-deficient cells may be the initial abnormality in the cascade of events leading to pituitary adenoma formation.

  3. Tumor-derived FH and SDH (show SDS Antibodies) mutations accumulate fumarate and succinate, leading to enzymatic inhibition of multiple alpha-KG-dependent dioxygenases and consequent alterations of genome-wide histone and DNA methylation (show HELLS Antibodies).

  4. Data show that two subunits of complex II (succinate dehydrogenase (show SDHD Antibodies), or SDH (show SDS Antibodies)), SDHA (show SDHA Antibodies) and SDHB, interacted specifically with SIRT3 (show SIRT3 Antibodies).

Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) Antigen Profile

Protein Summary

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

Gene names and symbols associated with SDHB

  • succinate dehydrogenase complex iron sulfur subunit B (SDHB) antibody
  • succinate dehydrogenase [ubiquinone] iron-sulfur subunit 3 (SDH2-3) antibody
  • Succinate dehydrogenase, subunit B (iron-sulfur) (SdhB) antibody
  • succinate dehydrogenase complex subunit B, iron sulfur (Ip) (sdhb) antibody
  • succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (Sdhb) antibody
  • succinate dehydrogenase complex iron sulfur subunit B (Sdhb) antibody
  • succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (sdhb) antibody
  • succinate dehydrogenase complex subunit B, iron sulfur (Ip) S homeolog (sdhb.S) antibody
  • 0710008N11Rik antibody
  • CG3283 antibody
  • CWS2 antibody
  • Dmel\\CG3283 antibody
  • fj46d06 antibody
  • IP antibody
  • PGL4 antibody
  • SDH antibody
  • SDH-Ip antibody
  • SDH1 antibody
  • SDH2 antibody
  • sdhB antibody
  • SDHIP antibody
  • succinate dehydrogenase 2-3 antibody
  • wu:fj46d06 antibody

Protein level used designations for SDHB

succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial , succinate dehydrogenase complex subunit B , CG3283-PA , COMPLEX II: iron-sulfur subunit , SdhB-PA , iron-sulfur protein subunit of succinate dehydrogenase , succinate dehydrogenase , succinate dehydrogenase B , succinate dehydrogenase Iron-sulfur , succinate dehydrogenase Iron-sulfur protein , succinate dehydrogenase iron protein , succinate dehydrogenase subunit b , iron-sulfur subunit of complex II , Iron-sulfur subunit of complex II , IP , ip

GENE ID SPECIES
100050091 Equus caballus
770063 Arabidopsis thaliana
35590 Drosophila melanogaster
100144957 Xenopus (Silurana) tropicalis
6390 Homo sapiens
478217 Canis lupus familiaris
414412 Sus scrofa
286840 Bos taurus
100328585 Oryctolagus cuniculus
67680 Mus musculus
298596 Rattus norvegicus
562149 Danio rerio
379939 Xenopus laevis
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