Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
Purification
Affinity chromatography purified via peptide column
Immunogen
Synthetic peptide corresponding to amino acids near the carboxy terminus of human BAFF Receptor The peptide sequence is identical between human and mouse origin.
WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice
Avoid freezing and thawing repeatly.
Storage
4 °C/-20 °C
Storage Comment
Store at 4 °C for short term use.Store at -20 °C for long term preservation.
Target
TNFRSF13C
(Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C))
Members in the TNF superfamily regulate immune responses and induce apoptosis.A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF4.BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion.Two receptors, TACI and BCMA, for BAFF were originally identified.A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3.Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival.BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-kappaB and c-jun N-terminal kinase. Synonyms: BAFF-R, BR3, BLyS