GZMB antibody (Biotin)

Catalog No. ABIN206366

Product Details anti-GZMB Antibody (Biotin)

Target: GZMB (Granzyme B (GZMB))

Reactivity: Human, Monkey, Rhesus Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This GZMB antibody is conjugated to Biotin

Application: Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificity: Recognizes the serine protease Granzyme B, which is expressed within the granules of cytolytic lymphocytes (CTLs). Granzyme B plays a key role in the induction of apoptosis by CTLs. After delivery to the target cell Granzyme B activates the cascade of caspases that finally results in cell death. Has been reported to function as a detection reagent in ELISA assays for soluble Granzyme B in conjunction with GB11 (MCA2120) as capture reagent.

Purification: Protein A purified

Immunogen: Purified human Granzyme B.

Type of Immunogen: Purified protein

Clone: GB10

Isotype: IgG1

Application Details

Application Notes: Approved: ELISA (1 μg/mL), Flo, IHC, IHC-Fr, IP

Usage: The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested. ELISA: This antibody has been reported to function as a detection reagent in sandwich ELISA assays for soluble Granzyme B in conjunction with GB11 (LS-C44295) as capture reagent.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: TBS, BSA, 0.001 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: 4°C or -20°C, Avoid freeze-thaw cycles.

Target Details for GZMB

Target: GZMB (Granzyme B (GZMB))

Alternative Name: GZMB / Granzyme B (GZMB Products)

Synonyms: CCPI antibody, CGL-1 antibody, CGL1 antibody, CSP-B antibody, CSPB antibody, CTLA1 antibody, CTSGL1 antibody, HLP antibody, SECT antibody, granzyme B antibody, GZMB antibody

Background: Name/Gene ID: GZMB
Subfamily: Serine S1
Family: Protease

Synonyms: GZMB, CCPI, CGL-1, Cathepsin G-like 1, CSP-B, CTLA-1, CTLA1, CGL1, CSPB, Fragmentin 2, GRB, HLP, Human lymphocyte protein, Fragmentin-2, SECT, Lymphocyte protease, T-cell serine protease 1-3E, C11, CTSGL1, Cytotoxic serine protease B, Granzyme B, Granzyme-2

Gene ID: 3002

Pathways: Apoptosis, Caspase Cascade in Apoptosis