GZMB antibody
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- Target See all GZMB Antibodies
- GZMB (Granzyme B (GZMB))
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Reactivity
- Human, Monkey, Rhesus Monkey
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This GZMB antibody is un-conjugated
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Application
- Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificity
- Recognizes the serine protease Granzyme B, which is important in the induction of apoptosis in target cells by cytolytic lymphocytes (CTLs). Granzyme B plays a key role in the induction of apoptosis by CTLs. After delivery to the target cell, Granzyme B activates the cascade of caspases that finally results in cell death. Has been reported to function as a capture reagent in ELISA assays for soluble Granzyme B in conjunction with biotin conjugated clone GB10 (MCA2119B) as detection reagent.
- Purification
- Protein A purified
- Immunogen
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Purified human Granzyme B.
Type of Immunogen: Purified protein - Clone
- GB11
- Isotype
- IgG1
- Top Product
- Discover our top product GZMB Primary Antibody
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- Application Notes
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Approved: ELISA (2 - 5 μg/mL), Flo (1:10 - 1:100), IHC, IHC-Fr, IP
Usage: Flow Cytometry: Use 10 μL of the suggested working dilution to label 10^6 cells or 100 μL whole blood. ELISA: This antibody has been reported to function as a capture reagent in sandwich ELISA assays for soluble Granzyme B in conjunction with biotin conjugated clone GB10 (LS-C44294) as detection reagent. - Comment
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Target Species of Antibody: Human
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Tris buffered saline, 0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- avoid freeze thaw cycles. Store undiluted.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles. Store undiluted.
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- Target
- GZMB (Granzyme B (GZMB))
- Alternative Name
- GZMB / Granzyme B (GZMB Products)
- Synonyms
- CCPI antibody, CGL-1 antibody, CGL1 antibody, CSP-B antibody, CSPB antibody, CTLA1 antibody, CTSGL1 antibody, HLP antibody, SECT antibody, granzyme B antibody, GZMB antibody
- Background
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Name/Gene ID: GZMB
Subfamily: Serine S1
Family: Protease
Synonyms: GZMB, CCPI, CGL-1, Cathepsin G-like 1, CSP-B, CTLA-1, CTLA1, CGL1, CSPB, Fragmentin 2, GRB, HLP, Human lymphocyte protein, Fragmentin-2, SECT, Lymphocyte protease, T-cell serine protease 1-3E, C11, CTSGL1, Cytotoxic serine protease B, Granzyme B, Granzyme-2 - Gene ID
- 3002
- Pathways
- Apoptosis, Caspase Cascade in Apoptosis
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