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FAK antibody (pSer843)
PTK2
Reactivity: Human, Mouse, Rat
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-FAK Antibody
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Target
See all FAK (PTK2) Antibodies
FAK (PTK2)
(PTK2 Protein tyrosine Kinase 2 (PTK2))
Binding Specificity
All epitopes for FAK antibodies
pSer843
Reactivity
All reactivities for FAK antibodies
Human, Mouse, Rat
Host
All hosts for FAK antibodies
Rabbit
Clonality
All clonalities for FAK antibodies
Polyclonal
Conjugate
All conjugates for FAK antibodies
This FAK antibody is un-conjugated
Application
All applications for FAK antibodies
Western Blotting (WB)
Specificity
The antibody detects endogenous level of FAK only when phosphorylated at serine 843.
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
FAK (phospho Ser843) antibody was raised against a peptide sequence around phosphorylation site of serine843 (R-G-S (p)-I-D) derived from Human FAK .
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
Western Blot: 1:500~1:1000
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store antibody at -20°C for up to one year.
Target Details for FAK
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Target
FAK (PTK2)
(PTK2 Protein tyrosine Kinase 2 (PTK2))
Alternative Name
FAK (PTK2 Products )
Synonyms
FADK antibody, FAK antibody, FAK1 antibody, FRNK antibody, PPP1R71 antibody, p125FAK antibody, pp125FAK antibody, PTK2 antibody, Fadk antibody, mKIAA4203 antibody, fak antibody, fak1a antibody, ptk2 antibody, ptk2a antibody, wu:fa18c04 antibody, zgc:66114 antibody, CG10023 antibody, CT28129 antibody, DFAK antibody, DFak antibody, DFak56 antibody, Dfak antibody, Dfak56 antibody, DmFAK antibody, Dmel\\CG10023 antibody, Fak56 antibody, Fak56D antibody, fak56 antibody, protein tyrosine kinase 2 antibody, protein tyrosine kinase 2 L homeolog antibody, PTK2 protein tyrosine kinase 2 antibody, protein tyrosine kinase 2ab antibody, Focal adhesion kinase antibody, PTK2 antibody, ptk2.L antibody, Ptk2 antibody, ptk2ab antibody, Fak antibody
Background
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.
Molecular Weight
120 kDa
Gene ID
5747
NCBI Accession
NP_001186578
UniProt
Q05397
Pathways
Response to Growth Hormone Stimulus , CXCR4-mediated Signaling Events , Smooth Muscle Cell Migration , Signaling of Hepatocyte Growth Factor Receptor , VEGF Signaling
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