GRB2 antibody (pSer159)
-
- Target See all GRB2 Antibodies
- GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))
-
Binding Specificity
- pSer159
-
Reactivity
- Human, Mouse, Rat
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This GRB2 antibody is un-conjugated
-
Application
- Western Blotting (WB)
- Specificity
- The antibody detects endogenous levels of GRB2 only when phosphorylated at serine 159.
- Purification
- Antibodies were purified by affinity-chromatography using epitope-specific peptide.
- Immunogen
- GRB2 (phospho Ser159) antibody was raised against a peptide sequence around phosphorylation site of Serine 159 (K-S-S (p)-A-P) derived from Human GRB2.
- Isotype
- IgG
- Top Product
- Discover our top product GRB2 Primary Antibody
-
-
- Application Notes
- Western Blot: 1:500~1:1000
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store antibody at -20°C for up to one year.
-
- Target
- GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))
- Alternative Name
- GRB2 (GRB2 Products)
- Synonyms
- GRB2 antibody, grb2 antibody, AA408164 antibody, Ash antibody, ASH antibody, EGFRBP-GRB2 antibody, Grb3-3 antibody, MST084 antibody, MSTP084 antibody, NCKAP2 antibody, wu:fb18e12 antibody, wu:fb34e06 antibody, zgc:73077 antibody, growth factor receptor bound protein 2 antibody, growth factor receptor-bound protein 2 antibody, growth factor receptor-bound protein 2b antibody, GRB2 antibody, grb2 antibody, Grb2 antibody, grb2b antibody
- Background
- This gene is a member of the GRB2-associated binding protein (GAB) gene family and is similar to the GAB1 gene. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
- Molecular Weight
- 100 kDa
- Gene ID
- 9846
- NCBI Accession
- NP_536739
- UniProt
- Q9UQC2
- Pathways
- RTK Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, EGFR Downregulation
-