Immunoprecipitation. This antibody is not recommended for Western blotting or Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Buffer
PBS containing 0.08 % Sodium Azide as preservative.
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store the antibody at -20 °C. Avoid repeated freezing and thawing. Shelf life: One year from despatch.
Expiry Date
12 months
Target
Retinoblastoma 1 (RB1)
Alternative Name
Retinoblastoma-Associated Protein / RB1 (RB1 Products)
Retinoblastoma encodes a phosphorylated protein p110 and binds and regulates E2F transcription factors. Rb functions as a major cell cycle regulator by its ability to repress gene transcription by all three RNA polymerases. In its hypophosphorylated form, Rb binds to a subset of E2F containing complexes converting them to repressors preventing expression of E2F target genes. These complexes repress transcription via E2F binding elements in the promotersof cell cycle control genes, such as E2F-1, c-myc, and cdc2 genes.Synonyms: OSRC, Rb, Retinoblastoma 1, p105-Rb, pRb, pp110