TNFRSF10B
(Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))
Reactivity
Mouse
Host
Hamster
Clonality
Monoclonal
Conjugate
This TNFRSF10B antibody is conjugated to PE
Application
Flow Cytometry (FACS), Immunoprecipitation (IP)
Purification
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
CD262 is a 55 kD protein also known as DR5, TRAIL-R2, Apo-2, TRICK2, and KILLER. DR5 is member 10B of the TNF receptor superfamily (TNFRSF10B), widely expressed in normal tissues and some tumor cell lines. The DR5 receptor binds to TRAIL and interacts with the cytoplasmic proteins TRADD and RIP. TRAIL binding to DR5 activates NF- κB and induces apoptosis. DR5 is induced by wild-type p53.