JAK3 antibody (N-Term)
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- Target See all JAK3 Antibodies
- JAK3 (Janus Kinase 3 (JAK3))
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Binding Specificity
- N-Term
- Reactivity
- Human, Mouse, Rat, Cow, Dog, Horse, Pig, Guinea Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This JAK3 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- APPSEETPLI PQRSCSLLST EAGALHVLLP ARGPGPPQRL SFSFGDHLAE
- Predicted Reactivity
- Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 92%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 93%
- Characteristics
- This is a rabbit polyclonal antibody against JAK3. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N-terminal region of human JAK3
- Top Product
- Discover our top product JAK3 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeat freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- JAK3 (Janus Kinase 3 (JAK3))
- Alternative Name
- JAK3 (JAK3 Products)
- Synonyms
- JAK-3 antibody, JAK3_HUMAN antibody, JAKL antibody, L-JAK antibody, LJAK antibody, fae antibody, wil antibody, RATJAK3 antibody, JAK antibody, Janus kinase 3 antibody, JAK3 antibody, Jak3 antibody
- Background
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The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).
Alias Symbols: JAKL, LJAK, JAK-3, L-JAK, JAK3_HUMAN
Protein Size: 619 - Molecular Weight
- 68 kDa
- Gene ID
- 3718
- NCBI Accession
- NM_000215, NP_000206
- UniProt
- Q8N1E8
- Pathways
- JAK-STAT Signaling, RTK Signaling, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus, Activated T Cell Proliferation, Unfolded Protein Response
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