NR3C2 antibody (C-Term)
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- Target See all NR3C2 Antibodies
- NR3C2 (Nuclear Receptor Subfamily 3, Group C, Member 2 (NR3C2))
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Binding Specificity
- C-Term
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Reactivity
- Human, Rat, Mouse, Horse, Cow
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This NR3C2 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- VSDLLEFCFY TFRESHALKV EFPAMLVEII SDQLPKVESG NAKPLYFHRK
- Cross-Reactivity
- Chicken, Human, Mouse (Murine), Rat (Rattus)
- Predicted Reactivity
- Cow: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against NR3C2. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human NR3C2
- Top Product
- Discover our top product NR3C2 Primary Antibody
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- Application Notes
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WB Suggested Anti-NR3C2 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:12500
Positive Control: PANC1 cell lysate.
Optimal working dilutions should be determined experimentally by the investigator. - Comment
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Antigen size: 867 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- NR3C2 (Nuclear Receptor Subfamily 3, Group C, Member 2 (NR3C2))
- Alternative Name
- NR3C2 (NR3C2 Products)
- Synonyms
- mr antibody, si:ch211-189l17.1 antibody, LOC100302443 antibody, NR3C2 antibody, LOC443144 antibody, MLR antibody, MR antibody, MCR antibody, NR3C2VIT antibody, Mlr antibody, mlr antibody, nuclear receptor subfamily 3, group C, member 2 antibody, nuclear receptor subfamily 3 group C member 2 antibody, mineralocorticoid receptor antibody, nuclear receptor subfamily 3 group C member 2 L homeolog antibody, nr3c2 antibody, NR3C2 antibody, LOC443144 antibody, Nr3c2 antibody, nr3c2.L antibody
- Background
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NR3C2 is a receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. It binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
Alias Symbols: MR, MCR, MLR, FLJ41052, NR3C2VIT, MGC133092, NR3C2
Protein Interaction Partner: RABAC1, RXRA, HSP90AA1, ACSL1, UBC, SRC, PPP5C, PPID, FKBP5, FKBP4, STUB1, AIP, TRIM24, NRIP1, DNAJC7, CAND1, SUMO1, UBE2I, EIF3I, PROX1, PIAS1, PIAS3, HSPA4, PTGES3, AR, NR3C1, ACTA1, ACTG1,
Protein Size: 867 - Molecular Weight
- 94 kDa
- Gene ID
- 4306
- NCBI Accession
- NM_001166104, NP_001159576
- UniProt
- B0ZBF5
- Pathways
- ACE Inhibitor Pathway, Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway
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