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MGMT antibody (AA 1-207)
MGMT
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-MGMT Antibody
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Target
See all MGMT Antibodies
MGMT
(O6-Methylguanine-DNA-Methyltransferase (MGMT))
Binding Specificity
All epitopes for MGMT antibodies
AA 1-207
Reactivity
All reactivities for MGMT antibodies
Human
Host
All hosts for MGMT antibodies
Rabbit
Clonality
All clonalities for MGMT antibodies
Polyclonal
Conjugate
All conjugates for MGMT antibodies
This MGMT antibody is un-conjugated
Application
All applications for MGMT antibodies
Western Blotting (WB)
Sequence
MDKDCEMKRT TLDSPLGKLE LSGCEQGLHE IKLLGKGTSA ADAVEVPAPA AVLGGPEPLM QCTAWLNAYF HQPEAIEEFP VPALHHPVFQ QESFTRQVLW KLLKVVKFGE VISYQQLAAL AGNPKAARAV GGAMRGNPVP ILIPCHRVVC SSGAVGNYSG GLAVKEWLLA HEGHRLGKPG LGGSSGLAGA WLKGAGATSG SPPAGRN
Cross-Reactivity
Human, Rat
Characteristics
Polyclonal Antibodies
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-207 of human MGMT (XP_005252739.1).
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
WB,1:500 - 1:2000
Restrictions
For Research Use only
Handling
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Buffer
PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Target Details for MGMT
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Target
MGMT
(O6-Methylguanine-DNA-Methyltransferase (MGMT))
Alternative Name
MGMT (MGMT Products )
Synonyms
AGT antibody, AI267024 antibody, Agat antibody, O-6-methylguanine-DNA methyltransferase antibody, MGMT antibody, Mgmt antibody
Background
Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma.,MGMT,Epigenetics & Nuclear Signaling,DNA Damage & Repair,MGMT
Molecular Weight
21 kDa
Gene ID
4255
UniProt
P16455
Pathways
DNA Damage Repair , Positive Regulation of Response to DNA Damage Stimulus
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