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HLA-DMB antibody (Middle Region)

HLA-DMB Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3029729
  • Target See all HLA-DMB Antibodies
    HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))
    Binding Specificity
    • 12
    • 12
    • 7
    • 7
    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 43
    • 1
    Human
    Host
    • 40
    • 3
    Rabbit
    Clonality
    • 39
    • 4
    Polyclonal
    Conjugate
    • 23
    • 4
    • 4
    • 4
    • 4
    • 4
    This HLA-DMB antibody is un-conjugated
    Application
    • 42
    • 31
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    Antigen affinity
    Immunogen
    An amino acid sequence from the middle region of human HLA-DM beta chain (NQKDTLMQRLRNGLQNCATH) was used as the immunogen for this HLA-DM antibody.
    Isotype
    IgG
    Top Product
    Discover our top product HLA-DMB Primary Antibody
  • Application Notes
    The stated application concentrations are suggested starting amounts. Titration of the HLA-DM antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
    Restrictions
    For Research Use only
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Storage
    -20 °C
    Storage Comment
    After reconstitution, the HLA-DM antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target
    HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))
    Alternative Name
    HLA-DM (Beta Chain) (HLA-DMB Products)
    Synonyms
    RING7 antibody, D6S221E antibody, RT1.DMb antibody, RT1.Mb antibody, MHC-DMB antibody, major histocompatibility complex, class II, DM beta antibody, RT1 class II, locus DMb antibody, HLA-DMB antibody, RT1-DMb antibody, PATR-DMB antibody
    Background
    Major histocompatibility complex, class II, DM beta, also known as D6S221E, RING7, HLA-DM histocompatibility type, beta chain, HLADMB or RING7, is a protein that in humans is encoded by the HLADMB gene. HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chains, both anchored in the membrane. It is located in intracellular vesicles. The protein plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. HLA-DMA and -DMB appear to encode subunits of a functional heterodimer that is critical in the pathway of class II antigen presentation.
    UniProt
    P28068
    Pathways
    Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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