Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 6 (SLC17A6) antibody

Catalog No. ABIN351383

Product Details

Target: Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 6 (SLC17A6)

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificity: Specific for VGLUT2.

Cross-Reactivity: Mouse, Rat

Cross-Reactivity (Details): Other species not yet tested.

Purification: IgG

Immunogen: A synthetic peptide from mouse VGluT2 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat.

Isotype: IgG

Application Details

Application Notes: IHC, WB. A concentration of 10-50 μg,ml recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.

Handling Advice: Avoid freeze and thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date: 12 months

Target Details

Target: Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 6 (SLC17A6)

Alternative Name: VGluT2 (SLC17A6 Products)

Synonyms: 2900073D12Rik antibody, DNPI antibody, VGLUT2 antibody, VGluT2 antibody, Dnpi antibody, Vglut2 antibody, VGLUT2.1 antibody, blu antibody, si:packt73.2 antibody, si:packt90.2 antibody, si:xx-packt73.2 antibody, slc17a6 antibody, vglut2a antibody, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6 antibody, solute carrier family 17 member 6 antibody, solute carrier family 17 (vesicular glutamate transporter), member 6b antibody, Slc17a6 antibody, SLC17A6 antibody, slc17a6b antibody

Background: FUNCTION: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane, Multi-pass membrane protein. Cell junction, synapse, synaptosome. TISSUE SPECIFICITY: Expressed in brain. Expressed in hippocampal neurons (at protein level). DEVELOPMENTAL STAGE: Expressed in brain throughout development. Transiently expressed in hippocampal neurons during the first week after birth, with expression decreasing thereafter. MISCELLANEOUS: Mice lacking this protein exhibit an elevated rate of perinatal lethality. Surviving animals display a strong reduction in evoked glutamergic responses in thalamic neurons. Reduction of protein level in homozygous and heterozygous knockouts leads to a graded reduction in the amplitude of the postsynaptic response to single vesicle fusion in thalamic neurons, consistent with a role for this protein in determining quantal size.,SLC17 Family,Vesicular glutamate transporter 2, VGlU2, Solute carrier family 17 member 6, Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter, Differentiation-associated BNPI, Slc17a6, Dnpi

UniProt: Q9JI12