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AKT1 antibody (pSer129)
AKT1
Reactivity: Human
DB
Host: Rabbit
Polyclonal
RB25385
unconjugated
Product Details anti-AKT1 Antibody
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Target
See all AKT1 Antibodies
AKT1
(V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1))
Binding Specificity
All epitopes for AKT1 antibodies
pSer129
Reactivity
All reactivities for AKT1 antibodies
Human
Host
All hosts for AKT1 antibodies
Rabbit
Clonality
All clonalities for AKT1 antibodies
Polyclonal
Conjugate
All conjugates for AKT1 antibodies
This AKT1 antibody is un-conjugated
Application
All applications for AKT1 antibodies
Dot Blot (DB)
Predicted Reactivity
M, Rat
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This AKT1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S129 of human AKT1.
Clone
RB25385
Isotype
Ig Fraction
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Discover our top product AKT1 Primary Antibody
Alternatives
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Application Details
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Application Notes
DB: 1:500
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date
6 months
References for anti-AKT1 antibody (ABIN389509)
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Bestgen, Belaid-Choucair, Lomberget, Le Borgne, Filhol, Cochet : "In Search of Small Molecule Inhibitors Targeting the Flexible CK2 Subunit Interface. " in: Pharmaceuticals (Basel, Switzerland) , Vol. 10 , Issue 1 , (2017 ) (PubMed ).
Melão, Spit, Cardoso, Barata : "Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity. " in: Haematologica , Vol. 101 , Issue 11 , pp. 1368-1379 , (2016 ) (PubMed ).
Target Details for AKT1
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Target
AKT1
(V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1))
Alternative Name
AKT1 (AKT1 Products )
Synonyms
AKT antibody, CWS6 antibody, PKB antibody, PKB-ALPHA antibody, PRKBA antibody, RAC antibody, RAC-ALPHA antibody, Akt antibody, Rac antibody, PKB/Akt antibody, PKBalpha antibody, AKT/PKB antibody, AKT1 antibody, Akt/PKB antibody, Akt1 antibody, CG4006 antibody, D-Akt antibody, DAKT1 antibody, DAKT1/PKB antibody, DAkt antibody, DAkt1 antibody, DPKB antibody, DRAC-PK antibody, DRAC-PK66 antibody, DRAC-PK85 antibody, Dakt antibody, Dakt1 antibody, Dmel\\CG4006 antibody, Dpkb antibody, PKB/AKT antibody, PKB/dAKT antibody, RacPK antibody, akt antibody, akt1 antibody, dAKT antibody, dAKT/dPKB antibody, dAKT1 antibody, dAkt antibody, dAkt/PKB antibody, dAkt1 antibody, dPKB antibody, dakt antibody, dakt1 antibody, l(3)04226 antibody, l(3)89Bq antibody, p-Akt antibody, pAkt antibody, ACT-5 antibody, akt-1 antibody, pkb antibody, v-akt antibody, v-akt1 antibody, xAct antibody, ATAKT1 antibody, F18A8.2 antibody, F18A8_2 antibody, K+ transporter 1 antibody, POTASSIUM TRANSPORTER antibody, AKT serine/threonine kinase 1 antibody, thymoma viral proto-oncogene 1 antibody, CG4006 gene product from transcript CG4006-RE antibody, actin beta antibody, v-akt murine thymoma viral oncogene homolog 1 S homeolog antibody, v-akt murine thymoma viral oncogene homolog 1 antibody, K+ transporter 1 antibody, Serine/threonine-protein kinase akt-1 antibody, AKT1 antibody, Akt1 antibody, ACTB antibody, akt1.S antibody, akt1 antibody, KT1 antibody, akt-1 antibody
Background
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.
Molecular Weight
55686
Gene ID
207
NCBI Accession
NP_001014431 , NP_001014432 , NP_005154
UniProt
P31749
Pathways
PI3K-Akt Signaling , RTK Signaling , TCR Signaling , AMPK Signaling , Interferon-gamma Pathway , TLR Signaling , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Response to Water Deprivation , Regulation of Actin Filament Polymerization , Carbohydrate Homeostasis , Glycosaminoglycan Metabolic Process , Cellular Glucan Metabolic Process , Regulation of Muscle Cell Differentiation , Cell-Cell Junction Organization , Regulation of Cell Size , Skeletal Muscle Fiber Development , Regulation of Carbohydrate Metabolic Process , Hepatitis C , Protein targeting to Nucleus , CXCR4-mediated Signaling Events , Signaling Events mediated by VEGFR1 and VEGFR2 , Negative Regulation of intrinsic apoptotic Signaling , Thromboxane A2 Receptor Signaling , Signaling of Hepatocyte Growth Factor Receptor , Positive Regulation of fat Cell Differentiation , VEGFR1 Specific Signals , VEGF Signaling , Warburg Effect
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