c-MET antibody (pTyr1356)

Catalog No. ABIN389596

This Rabbit Polyclonal antibody specifically detects c-MET in DB. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for c-MET antibody (pTyr1356) (ABIN389596)

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This c-MET antibody is un-conjugated

Application: Dot Blot (DB)

Clone: RB24512

Product Details anti-c-MET Antibody

Binding Specificity: pTyr1356

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MET Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1356 of human MET.

Isotype: Ig Fraction

Application Details

Application Notes: DB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-c-MET antibody (ABIN389596)

Xu, Xia, Baker, Zhou, Cha, Voorhees, Fisher: "Receptor-type protein tyrosine phosphatase beta (RPTP-beta) directly dephosphorylates and regulates hepatocyte growth factor receptor (HGFR/Met) function." in: The Journal of biological chemistry, Vol. 286, Issue 18, pp. 15980-8, (2011) (PubMed).

Target Details for c-MET

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Alternative Name: MET

Background: The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma.

Molecular Weight: 155541

Gene ID: 4233

NCBI Accession: NP_000236, NP_001120972

UniProt: P08581

Pathways: RTK Signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor