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ATR antibody (Internal Region)

ATR Reactivity: Human, Mouse, Rat, Xenopus laevis, Dog, Fish, Monkey WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN401401
  • Target See all ATR Antibodies
    ATR (Ataxia Telangiectasia and Rad3 Related (ATR))
    Binding Specificity
    • 2
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    Human, Mouse, Rat, Xenopus laevis, Dog, Fish, Monkey
    Host
    • 5
    • 2
    Rabbit
    Clonality
    • 5
    • 2
    Polyclonal
    Conjugate
    • 7
    This ATR antibody is un-conjugated
    Application
    • 6
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody is specific for ATR protein.
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse, Rat, Monkey, Canine, Fish, Xenopus.
    Species reactivity (tested):Human.
    Purification
    Affinity chromatography
    Immunogen
    Synthetic peptide corresponding to an internal region of human ATR protein
    Isotype
    IgG
    Top Product
    Discover our top product ATR Primary Antibody
  • Application Notes
    ELISA: 1/15,000 - 1/70,000. Western Blot: 1/1,000 - 1/5,000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.28 mg/mL (by UV absorbance at 280 nm)
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
  • Target
    ATR (Ataxia Telangiectasia and Rad3 Related (ATR))
    Alternative Name
    ATR / FRP1 (ATR Products)
    Synonyms
    ATR antibody, si:dkey-231j24.1 antibody, FCTCS antibody, FRP1 antibody, MEC1 antibody, SCKL antibody, SCKL1 antibody, XATR antibody, frp1 antibody, mec1 antibody, sckl antibody, sckl1 antibody, ARABIDOPSIS THALIANA ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED antibody, ATATR antibody, ATRAD3 antibody, Ataxia telangiectasia-mutated and RAD3-related antibody, MHK7.5 antibody, MHK7_5 antibody, ataxia telangiectasia and Rad3 related antibody, ATR serine/threonine kinase antibody, ATR serine/threonine kinase L homeolog antibody, Ataxia telangiectasia-mutated and RAD3-like protein antibody, Atr antibody, ATR antibody, atr antibody, atr.L antibody
    Background
    Ataxia Telangiectasia Mutated (ATM) and Rad 3-related protein (ATR) is a phosphatidylinositol kinase (PK)-related kinase which functions in response to DNA damage and repair as well as at DNA replication checkpoints during the cell cycle. ATR activates checkpoint signaling upon genotoxic stresses, such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. ATR is a member of the DNA-PK kinase family and is closely related to ATM and DNAPK for which DNA stimulates the observed kinase activity. Chromosomal remodeling proteins have also been reported to associate with ATR complexes, including histone deacetylases (HDAC1, HDAC2 and CHD4). ATR is known to phosphorylate BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and TP53/p53 which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. ATR is a nuclear protein, but can also be found in PML nuclear bodies in certain cell types. ATR is recruited to chromatin during Sphase and redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling.Synonyms: Ataxia telangiectasia and Rad3-related protein, FRAP-related protein 1, Serine/threonine-protein kinase ATR
    Gene ID
    545
    NCBI Accession
    NP_001175
    UniProt
    Q13535
    Pathways
    p53 Signaling, Apoptosis, DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus
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