STAT5B antibody (pThr694)

Catalog No. ABIN452649

Product Details anti-STAT5B Antibody

Target: STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))

Binding Specificity: pThr694

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This STAT5B antibody is un-conjugated

Application: Enzyme Immunoassay (EIA)

Specificity: Reactive to tyrosine699 phosphorylated Human STAT5b peptide fragment conjugated with KLH or the peptide-BSA conjugate, but not reactive to unconjugated KLH or BSA.

Characteristics: Synonyms: STAT-5B, Signal transducer and activator of transcription 5B

Purification: Affinity chromatography on Protein G

Immunogen: Peptide of a phosphorlylated fragment of STAT5b(p-T694) , conjugated with KLH

Clone: A4B9

Isotype: IgG1

Application Details

Application Notes: Indirect ELISA: The suggested antigen coating quantity is 1 μg/mL of peptide/or peptideconjugating in pH 9.5 carbonate buffer, 100 μL/well
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Reconstitution: Restore with Double distillated water to adjust the final concentration to 1.0 mg/mL

Buffer: 0.01 M PBS, pH 7.2 without preservatives

Preservative: Without preservative

Storage: -20 °C

Storage Comment: Prior to and following reconstitution store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for STAT5B

Target: STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))

Alternative Name: STAT5B (STAT5B Products)

Synonyms: STAT5 antibody, stat5 antibody, STAT5A antibody, STAT5B antibody, signal transducer and activator of transcription 5B antibody, signal transducer and activator of transcription 5B S homeolog antibody, Signal transducer and activator of transcription 5B antibody, STAT5B antibody, Stat5b antibody, stat5b.S antibody, LOC490969 antibody, sta5b antibody, LOC100566752 antibody, LOC100052954 antibody

Background: Stat5b is a transcription factor that is activated in response to extra-cellular stimuli including IL-2, IL-4, MCSF and a variety of growth factors. In the process, receptor associated kinases phosphorylate Stat5b. Stat5b, then, forms dimers and translocates to nucleus. Inside nucleus, Stat5b binds to the promoter region on various genes to regulate biological processes such as apoptosis, T cell receptor signalling, and adult mammary gland development. Fusion of Stat5b to retinoic acid receptor-alpha (RARα) gene was identified in a small subgroup of acute promyelocytic leukemia patients.Synonyms: STAT-5B, Signal transducer and activator of transcription 5B

Gene ID: 6777

UniProt: P51692

Pathways: JAK-STAT Signaling, RTK Signaling, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation